The Biology of Bone Marrow Transplantation for Severe Combined Immune Deficiency

Gati, 1968, Immunological reconstitution of sex-linked lymphopenic immunological deficiency, Lancet, 2, 1366, 10.1016/S0140-6736(68)92673-1 Keightley, 1975, Successful fetal liver transplantation in a child with severe combined immunodeficiency, Lancet, 2, 850, 10.1016/S0140-6736(75)90238-X O'Reilly, 1977, Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor, N. Engl. J. Med., 297, 1311, 10.1056/NEJM197712152972403 Reinherz, 1982, Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency, Proc. Natl. Acad. Sci. U.S.A., 79, 6047, 10.1073/pnas.79.19.6047 Reisner, 1983, Transplantation for sever combined immunodeficiency with HLA-A,B,D, Dr incompatible parental marrow fractionated by soybean agglutinin and sheep red blood cells, Blood, 61, 341, 10.1182/blood.V61.2.341.341 Hitzig, 1961, Hereditäre lymphoplasmocytäse dysginesie, Schweiz. Med. Wochenschr., 91, 1625 De Vaal, 1959, Reticular dysgenesia, Lancet, 2, 113 Hitzig, 1971, Heterogeneity of phenotypic expression in a family with Swiss-type agammaglobulinemia: Observations in the acquisition of agammaglobulinemia, J. Pediatr., 78, 968, 10.1016/S0022-3476(71)80426-2 Giblett, 1972, Adenosine-deaminase deficiency in 2 patients with severely impaired cellular immunity, Lancet, 2, 1067, 10.1016/S0140-6736(72)92345-8 Valerio, 1986, One adenosine deaminase allele in a patient with severe combined immunodeficiency contains a pair mutation abolishing enzyme activity, EMBO J., 5, 113, 10.1002/j.1460-2075.1986.tb04184.x Bonithron, 1985, Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency, J. Clin. Invest., 76, 894, 10.1172/JCI112050 Markert, 1987, Identification of a deletion in the adenosine deaminase gene in a child with severe combined immunodeficiency, J. Immunol., 138, 3203 Ballet, 1976, Inhibition of maturation of human precursor lymphocytes by coformycin, an inhibitor of the enzyme adenosine deaminase, J. Exp. Med., 143, 1271, 10.1084/jem.143.5.1271 Carson, 1977, Lymphospecific toxicity in adenosine deaminase deficiency and urine nucleoside phosphorylase deficiency. Possible role of nucleoside kinase(s), Proc. Natl. Acad. Sci. U.S.A., 74, 5677, 10.1073/pnas.74.12.5677 Polmar, 1979, Enzyme replacement and other biochemical approaches to the therapy of adenosine deaminase deficiency, Ciba Found. Symp., 68, 213 Polmar, 1976, Enzyme replacement therapy for adenosine deaminase deficiency and severe combined immunodeficiency, N. Engl. J. Med., 295, 1337, 10.1056/NEJM197612092952402 Hershfield, 1987, Treatment of adenosine deaminase deficiency with polyethyene glycol-modified adenosine deaminase, N. Engl. J. Med., 316, 589, 10.1056/NEJM198703053161005 Lischner, 1967, Lymphocytes in congenital absence of the thymus, Nature (London), 214, 580, 10.1038/214580a0 Touraine, 1974, Differentiation of human bone marrow cells into T lymphocytes by in vitro incubation with thymic extracts, Clin. Exp. Immunol., 17, 151 Wara, 1975, Thymosin activity in patients with cellular immunodeficiency, N. Engl. J. Med., 292, 70, 10.1056/NEJM197501092920204 Cleveland, 1968, Fetal thymic transplant in a case of DiGeorge's syndrome, Lancet, 2, 1211, 10.1016/S0140-6736(68)91694-2 August, 1968, Implantation of fetal thymus, restoring immunological competence in a patient with thymus aplasia (DiGeorge's syndrome), Lancet, 2, 1210, 10.1016/S0140-6736(68)91693-0 Pyke, 1975, Demonstration of an intrathymic defect in a case of severe combined immunodeficiency disease, N. Engl. J. Med., 293, 424, 10.1056/NEJM197508282930904 Vollger, 1987, Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens, J. Immunol., 138, 358 Marrack, 1987, The T cell receptor, Science, 238, 1073, 10.1126/science.3317824 Wirt, 1989, Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease, N. Engl. J. Med., 321, 370, 10.1056/NEJM198908103210606 Durum, 1985, Interleukin 1: An immunological perspective, Annu. Rev. Immunol., 3, 263, 10.1146/annurev.iy.03.040185.001403 Sahdev, 1989, Correlation between interleukin-1 production and engraftment of transplanted bone marrow stem cells in patients with lethal immunodeficiencies, Blood, 73, 1712, 10.1182/blood.V73.6.1712.1712 Chu, 1984, Immunodeficiency with defective T-cell response to interleukin 1, Proc. Natl. Acad. Sci. U.S.A., 81, 4945, 10.1073/pnas.81.15.4945 Weinberg, 1990, Severe combined immune deficiency due to a specific defect in interleukin-2 production, N. Engl. J. Med., 322, 1718, 10.1056/NEJM199006143222406 Weinberg, 1989, Severe combined immune deficiency (SCID) due to defective interleukin 2 receptor α (IL2Rα) expression, Pediatr. Res., 25, 170a Yount, 1978, Lymphocyte subpopulations in X-linked severe combined immunodeficiency (SCID), Am. J. Med., 65, 847, 10.1016/0002-9343(78)90805-7 Gehrz, 1980, Defective membrane function in a patient with severe combined immunodeficiency disease, Clin. Exp. Immunol., 39, 344 Chatila, 1989, An immunodeficiency characterized by defective signal transduction in T lymphocytes, N. Engl. J. Med., 320, 696, 10.1056/NEJM198903163201104 Pahwa, 1989, Recombinant interleukin 2 therapy in severe combined immunodeficiency disease, Proc. Natl. Acad. Sci. U.S.A., 86, 5069, 10.1073/pnas.86.13.5069 Alarcon, 1988, Familial defect in the surface expression of the T-cell receptor-CD3 complex, N. Engl. J. Med., 319, 1203, 10.1056/NEJM198811033191806 Touraine, 1978, Combined immunodeficiency disease associated with absence of cell surface HLA-A and B antigens, J. Pediatr., 93, 47, 10.1016/S0022-3476(78)80598-8 Hadam, 1984, Congenital agammaglobulinemia associated with lack of expression of HLA-D region antigens, 43 De Préval, 1988, Regulation of genes for HLA class II antigens in cell lines from patients with severe combined immunodeficiency, N. Engl. J. Med., 318, 1295, 10.1056/NEJM198805193182003 Mellins, 1990, Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes, Nature (London), 343, 71, 10.1038/343071a0 Morio, 1990, Phenotypic profile and functions of T cell receptor-γδ-bearing cells from patients with primary immunodeficiency syndrome, J. Immunol., 144, 1270 Faure, 1988, Characterization of human peripheral lymphocytes expressing the CD3-γ/δ complex with antireceptor monoclonal antibodies, J. Immunol., 141, 3357 Schuler, 1986, Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency, Cell (Cambridge, Mass.), 46, 963, 10.1016/0092-8674(86)90695-1 Parkman, 1975, Severe combined immunodeficiency and adenosine deaminase deficiency, N. Engl. J. Med., 292, 714, 10.1056/NEJM197504032921402 O'Reilly, 1989, The use of HLA-non-identical T-cell-depleted marrow transplants for correction of severe combined immunodeficiency disease, Immunodefic. Rev., 1, 273 Stiehm, 1972, Immunologic reconstitution in severe combined immunodeficiency without bone marrow chromosomal chimerism, N. Engl. J. Med., 286, 797, 10.1056/NEJM197204132861501 Levinsky, 1983, Successful bone-marrow transplantation for reticular dysgenesis, Lancet, 1, 671, 10.1016/S0140-6736(83)91968-2 Fischer, 1983, Heterogeneity of immunologic and enzymatic deficiencies in the familial reticuloendotheliosis syndrome, Birth Defects, Orig. Artic. Ser., 19, 317 Polmar, 1975, Restoration of in-vitro lymphocyte responses with exogenous adenosine deaminase in a patient with severe combined immunodeficiency, Lancet, 2, 743, 10.1016/S0140-6736(75)90726-6 Parkman, 1984, Busulfan and total body irradiation as antihematopoietic stem cell agents in the preparation of patients with congenital bone marrow disorders for allogeneic bone marrow transplantation, Blood, 64, 852, 10.1182/blood.V64.4.852.852 Goldsobel, 1987, Bone marrow transplantation in DiGeorge syndrome, J. Pediatr., 111, 40, 10.1016/S0022-3476(87)80339-6 Borzy, 1989, Successful bone marrow transplantation with split lymphoid chimerism in DiGeorge Syndrome, J. Clin. Immunol., 9, 386, 10.1007/BF00917103 Polmar, 1986, Long-term immunological reconstitution by peripheral blood leucocytes in severe combined immune deficiency disease: Implications for the role of mature lymphocytes in histocompatible bone marrow transplantation, Clin. Exp. Immunol., 64, 518 Kinney, 1979, Bone marrow transplantation for severe combined immunodeficiency, Eur. J. Pediatr., 131, 155, 10.1007/BF00538940 Fischer, 1986, Bone marrow transplantation for immunodeficiencies and osteopetrosis: European survey, 1968–1985, Lancet, 2, 1080, 10.1016/S0140-6736(86)90477-0 O'Reilly, 1983, Transplantation of hematopoietic cells for lethal congenital immunodeficiencies, Birth Defects, Orig. Artic. Ser., 19, 129 Durandy, 1982, Prenatal diagnosis of severe combined immunodeficiency, J. Pediatr., 101, 995, 10.1016/S0022-3476(82)80029-2 Hirschhorn, 1975, Adenosine deaminase deficiency in a child diagnosed prenatally, Lancet, 1, 73, 10.1016/S0140-6736(75)91075-2 Goodship, 1988, Use of X chromosome inactivation to establish carrier status for X-linked severe combined immunodeficiency, Lancet, 1, 729, 10.1016/S0140-6736(88)91537-1 Hall, 1983, Aerosolized ribavirin treatment of infants with respiratory syncitial viral infection: A randomized doubleblind study, N. Engl. J. Med., 308, 1443, 10.1056/NEJM198306163082403 Emanuel, 1988, Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high dose intravenous immune globulin, Ann. Intern. Med., 109, 777, 10.7326/0003-4819-109-10-777 Shepp, 1985, Oral acyclovir therapy for mucocutaneous herpes simplex virus infections in immunocompromised marrow transplant recipients, Ann. Intern. Med., 102, 783, 10.7326/0003-4819-102-6-783 Uphoff, 1958, Preclusion of secondary phase of irradiation syndrome by inoculation of fetal hematopoietic tissue following letal total body X-irradiation, J. Natl. Cancer Inst. (U.S.), 20, 625 Niewisch, 1970, Hemopoietic stem distribution in tissues of fetal and new born mice, J. Cell. Physiol., 76, 107, 10.1002/jcp.1040760115 Moore, 1970, Density distribution analysis of in vivo and in vitro colony forming cells in developing fetal liver, J. Cell. Physiol., 75, 181, 10.1002/jcp.1040750207 Buckley, 1976, Correction of severe combined immunodeficiency by fetal liver cells, N. Engl. J. Med., 294, 1076, 10.1056/NEJM197605132942002 O'Reilly, 1980, Fetal tissue transplants for severe combined immunodeficiency—their limitations and functional potential, 419 Zinkernagel, 1980, On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras, J. Immunol., 124, 2356 Singer, 1981, Self recognition in allogeneic radiation bone marrow chimeras. A radiation-resistant host element dictates the self specificity and immune response phenotype of T-helper cells, J. Exp. Med., 153, 1286, 10.1084/jem.153.5.1286 Hong, 1976, Reconstitution of B and T lymphocyte function in severe combined immunodeficiency disease after transplantation with thymic epithelium, Lancet, 2, 1270, 10.1016/S0140-6736(76)92031-6 Hong, 1984, Transplantation of cultured thymic epithelium, 45 Borzy, 1979, Fatal lymphoma after transplantation of cultured thymus in children with combined immunodeficiency disease, N. Engl. J. Med., 301, 565, 10.1056/NEJM197909133011101 Dicke, 1968, The selective elimination of immunologically competent cells from bone marrow and lymphatic cell mixtures. II. Mouse spleen cell fractionation on a discontinuous albumin gradient, Transplantation, 6, 562, 10.1097/00007890-196807000-00009 von Boehmer, 1975, Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras, J. Exp. Med., 141, 322, 10.1084/jem.141.2.322 Sprent, 1975, Association of immunity and tolerance of host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow cells from one parental strain, J. Exp. Med., 142, 321, 10.1084/jem.142.2.321 Onoe, 1980, Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice, J. Exp. Med., 151, 115, 10.1084/jem.151.1.115 Muller-Ruchholtz, 1976, Bone marrow transplantation in rats across strong histocompatibility barriers by selective elimination of lymphoid cells in donor marrow, Transplant Proc., 8, 537 Hamilton, 1981, Anti-recipient cytotoxic T lymphocyte precursors are present in the spleen of mice with acute graft versus host disease due to minor histocompatibility antigens, J. Immunol., 126, 621 Reisner, 1978, Hematopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins, Proc. Natl. Acad. Sci. U.S.A., 75, 2933, 10.1073/pnas.75.6.2933 Reisner, 1980, Allogeneic bone marrow transplantation using stem cells fractionated by lectins. VI. In vitro analysis of human and monkey bone marrow cells fractionated by sheep red blood cells and soybean agglutinin, Lancet, 2, 1320, 10.1016/S0140-6736(80)92394-6 Frame, 1989, T-cell depletion of human bone marrow. Comparison of Campath-1 plus complement, anti-T cell ricin A chain immunotoxin and soybean agglutinin alone or in combination with sheep erythrocytes or immunomagnetic beads, Transplantation, 47, 984, 10.1097/00007890-198906000-00013 Ritz, 1983, Use of monoclonal antibodies in autologous and allogeneic bone marrow transplantation, Clin. Hematol., 12, 813, 10.1016/S0308-2261(83)80012-5 Hayward, 1982, Failure of a panreactive anti-T cell antibody, OKT3, to prevent graft versus host disease in severe combined immunodeficiency, J. Pediatr., 100, 665, 10.1016/S0022-3476(82)80783-X Trigg, 1985, Clinical trial depleting T lymphocytes from donor marrow for matched and mismatched allogeneic bone marrow transplants, Cancer Treat. Rep., 69, 377 Parkman, 1986, Antibody-treated bone marrow transplantation for patients with severe combined immune deficiency, Clin. Immunol. Immunopathol., 40, 142, 10.1016/0090-1229(86)90078-4 Wesolowski, 1984, Heparin inhibition of antibody-dependent complement-mediated lysis, Exp. Hematol., 12, 700 Filipovitch, 1983, Mismatched bone marrow transplantation at the University of Minnesota: use of related donors other than HLA MLC identical siblings and T-cell depletion, 769 Gotoh, 1985, Deficiency of NK activity and HNK-1+ cells after transplantation of fetal thymus and liver or haploidentical soybean agglutinin treated marrow cells in two severe combined immunodeficiency patients, Clin. Exp. Immunol., 61, 608 Fischer, 1986, HLA-haploidentical bone marrow transplantation for severe combined immunodeficiency using E-rosette fractionation and cyclosporine, Blood, 67, 444, 10.1182/blood.V67.2.444.444 O'Reilly, 1983, Transplantation for severe combined immunodeficiency using histoimcompatible parental marrow fractionated by soybean agglutinin and sheep red blood cells: Experience in six consecutive cases, Transplant. Proc., 17, 455 O'Reilly, 1986, Evaluation of HLA-haplotype disparate parental marrow grafts depleted of T lymphocytes by differential agglutination with a soybean lectin and E-rosette depletion for the treatment of severe combined immunodeficiency, Vox Sang., 51, 81, 10.1111/j.1423-0410.1986.tb02013.x Friedrich, 1985, Severe combined immunodeficiency: Treatment by bone marrow transplantation in 15 infants using HLA-haploidentical donors, Eur. J. Pediatr., 144, 125, 10.1007/BF00451897 O'Reilly, 1987, HLA nonidentical T cell depleted marrow transplants: a comparison of results in patients treated for leukemia and severe combined immunodeficiency disease, Transplant. Proc., 19, 55 Bordignon, 1989, Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia. II. In vitro analyses of host effector mechanisms, Blood, 74, 2237, 10.1182/blood.V74.6.2237.2237 Cudkowicz, 1971, Peculiar immunobiology of bone marrow allografts. II. Rejection of parental grafts by resistant F1 hybrid mice, J. Exp. Med., 134, 1513, 10.1084/jem.134.6.1513 Keissling, 1977, Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts, Eur. J. Immunol., 7, 655, 10.1002/eji.1830070915 Daley, 1984, Natural resistance of lethally irradiated F1 hybrid mice to parental marrow grafts is a function of H-2, H-h restricted effectors, J. Exp. Med., 159, 1132, 10.1084/jem.159.4.1132 Murphy, 1987, Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID), J. Exp. Med., 165, 1212, 10.1084/jem.165.4.1212 Yankelevich, 1989, A novel cell type responsible for marrow graft rejection in mice, J. Immunol., 142, 3423 Fischer, 1986, Prevention of graft failure by an anti-HLFA-1 monoclonal antibody in HLA-mismatched bone-marrow transplantation, Lancet, 2, 1058, 10.1016/S0140-6736(86)90465-4 Kernan, 1986, Cloneable T lymphocytes in T-cell depleted bone marrow transplants correlate with development of graft-versus-host disease, Blood, 68, 770, 10.1182/blood.V68.3.770.770 Hamilton, 1981, Anti-recipient cytotoxic T-lymphocyte precursors are present in the spleens of mice with acute graft versus host disease due to minor histocompatibility antigens, J. Immunol., 126, 621 Sprent, 1981, Immunogenetics of graft-versus-host reactions to minor histocompatibility antigens, Immunol. Today., 1, 189, 10.1016/0167-5699(81)90070-0 Pollack, 1982, Identification by HLA typing of intrauterine-derived material T-cell in four patients with severe combined immunodeficiency, N. Engl. J. Med., 307, 662, 10.1056/NEJM198209093071106 Flomenberg, 1983, The use of T cell culture techniques to establish the presence of an intrauterinederived maternal T cell graft in a patient with severe combined immunodeficiency (SCID), Transplantation, 36, 733, 10.1097/00007890-198336060-00031 Thompson, 1984, Phenotype and function of engrafted maternal T cells in patients with severe combined immunodeficiency, J. Immunol., 133, 2513 Bevan, 1978, The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells, Immunol. Rev., 42, 3, 10.1111/j.1600-065X.1978.tb00256.x Ron, 1986, T cell specificity in twice irradiated F1 parent bone marrow chimeras: failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction, J. Immunol., 137, 1764 Kisielow, 1988, Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes, Nature (London), 333, 742, 10.1038/333742a0 De Villartay, 1986, Self-tolerance to host and donor following HLA-mismatched bone marrow transplantation, Eur. J. Immunol., 16, 117, 10.1002/eji.1830160202 Schiff, 1987, Modified responses to recipient and donor B cells by genetically donor T cells from human haploidentical bone marrow chimeras, J. Immunol., 138, 2088 Keever, 1988, Tolerance of engrafted donor T cells following bone marrow transplantation for severe combined immunodeficiency, Clin. Immunol. Immunopathol., 48, 261, 10.1016/0090-1229(88)90020-7 von Boehmer, 1986, Minor but not major histocompatibility antigens of thymic epithelium tolerize precursors of cytolytic T cells, Nature (London), 320, 626, 10.1038/320626a0 Lo, 1986, Identity of cells that imprint H-2 restricted T cell specificity in the thymus, Nature (London), 319, 672, 10.1038/319672a0 Keever, 1989, Loss of tolerance associated with disappearance of B cells in a patient sequentially transplanted with paternal and maternal bone marrow for the treatment of severe combined immunodeficiency disease, Hum. Immunol., 26, 27, 10.1016/0198-8859(89)90030-X Vandekerckhove, 1990, Analysis of the donor-specific cytotoxic T lymphocyte repertoire in a patient with a long term surviving allograft, J. Immunol., 144, 1288 Roncarolo, 1988, Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera, J. Exp. Med., 167, 1523, 10.1084/jem.167.5.1523 Friedrich, 1986, Analysis of the immunoreconstitution in 19 patients with severe combined immunodeficiency after haploidentical bone marrow transplantation, 351 Rosenkrantz, 1987, In vitro correlates of graft-host tolerance after HLA-matched and mismatched marrow transplants: Suggestions from limiting dilution analysis, Transplant. Proc., 19, 98 Parkman, 1989, Graft-versus-host disease: An alternative hypothesis, Immunol. Today, 10, 362, 10.1016/0167-5699(89)90267-3 Buckley, 1986, Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation, J. Immunol., 136, 2398 Silber, 1987, Reconstitution of T- and B-cell function after T-lymphocyte-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency due to adenosine deaminase deficiency, Clin. Immunol. Immunopathol., 44, 317, 10.1016/0090-1229(87)90075-4 Keever, 1989, Immune reconstitution following bone marrow transplantation: Comparison of recipients of T cell-depleted marrow with recipients of conventional marrow grafts, Blood, 73, 1340, 10.1182/blood.V73.5.1340.1340 August, 1971, Onset of lymphocyte function in the developing human fetus, Pediatr. Res., 5, 539, 10.1203/00006450-197110000-00006 Kay, 1970, Response of human fetal thymocytes to phytohaemagglutinin (PHA), Immunology, 18, 393 van Furth, 1965, The immunological development of the human fetus, J. Exp. Med., 122, 1173, 10.1084/jem.122.6.1173 Carr, 1973, Dissociation of resonses to phytohaemagglutinin and adult allogeneic lymphocytes in human fetal lymphoid tissues, Nature (London), 241, 279 Parkman, 1973, Discontinuous density gradient analysis of the developing human thymus, Cell. Immunol., 8, 328, 10.1016/0008-8749(73)90122-6 Rozans, 1986, Long-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods, J. Immunol., 136, 4040 Ghory, 1986, Appearance of multiple benign paraproteins during early engraftment of soy lectin T-cell depleted haploidentical bone marrow cells in severe combined immunodeficiency, J. Clin. Immunol., 6, 161, 10.1007/BF00918749 Wu, 1968, Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system, J. Exp. Med., 127, 455, 10.1084/jem.127.3.455 Keller, 1985, Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors, Nature (London), 318, 149, 10.1038/318149a0 Lum, 1987, The kinetics of immune reconstitution after human marrow transplantation, Blood, 69, 369, 10.1182/blood.V69.2.369.369 Zinkernagel, 1988, Thymic selection of H-2-incompatible bone marrow cells in SCID mice, J. Exp. Med., 168, 1187, 10.1084/jem.168.3.1187 Small, 1989, Characterization of B cells in severe combined immunodeficiency disease, Hum. Immunol., 25, 181, 10.1016/0198-8859(89)90081-5 Roncarolo, 1988, Antigen recognition by MHC-incompatible cells of a human mismatched chimera, J. Exp. Med., 168, 2139, 10.1084/jem.168.6.2139 Chu, 1983, Major histocompatibility restriction of antigen recognition by T-cells in a recipient of haplotype mismatched human bone marrow transplantation, J. Clin. Invest., 72, 1124, 10.1172/JCI111037 Geha, 1987, Cell cooperation in haploidentical bone marrow transplant recipient, Transplant. Proc., 19, 117