The Beclin 1 network regulates autophagy and apoptosis

Cell Death and Differentiation - Tập 18 Số 4 - Trang 571-580 - 2011
Akio Kihara1, Wei‐Guo Zhu2, Michael T. Lotze2, Daolin Tang2
1Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh , Pittsburgh, PA , USA
2Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, USA

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Yang Z, Klionsky DJ . Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12: 814–822.

Tooze SA, Yoshimori T . The origin of the autophagosomal membrane. Nat Cell Biol 2010; 12: 831–835.

Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T et al. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 2009; 461: 654–658.

Zhang J, Randall MS, Loyd MR, Dorsey FC, Kundu M, Cleveland JL et al. Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood 2009; 114: 157–164.

Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R . Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ 2008; 15: 1318–1329.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010; 465: 942–946.

Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 1998; 72: 8586–8596.

He C, Levine B . The Beclin 1 interactome. Curr Opin Cell Biol 2010; 22: 140–149.

Oberstein A, Jeffrey PD, Shi Y . Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282: 13123–13132.

Yue Z, Jin S, Yang C, Levine AJ, Heintz N . Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100: 15077–15082.

Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS et al. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009; 5: 303–306.

Liang XH, Yu J, Brown K, Levine B . Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 2001; 61: 3443–3449.

Adi-Harel S, Erlich S, Schmukler E, Cohen-Kedar S, Segev O, Mizrachy L et al. Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment. J Cell Biochem 2010; 110: 1262–1271.

Noble CG, Dong JM, Manser E, Song H . Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin 1. J Biol Chem 2008; 283: 26274–26282.

Ku B, Woo JS, Liang C, Lee KH, Hong HS, E X et al. Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PLoS Pathog 2008; 4: e25.

Copetti T, Bertoli C, Dalla E, Demarchi F, Schneider C . p65/RelA modulates BECN1 transcription and autophagy. Mol Cell Biol 2009; 29: 2594–2608.

Djavaheri-Mergny M, Amelotti M, Mathieu J, Besancon F, Bauvy C, Souquere S et al. NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem 2006; 281: 30373–30382.

Criollo A, Senovilla L, Authier H, Maiuri MC, Morselli E, Vitale I et al. The IKK complex contributes to the induction of autophagy. Embo J 2010; 29: 619–631.

Polager S, Ofir M, Ginsberg D . E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene 2008; 27: 4860–4864.

Kusama Y, Sato K, Kimura N, Mitamura J, Ohdaira H, Yoshida K . Comprehensive analysis of expression pattern and promoter regulation of human autophagy-related genes. Apoptosis 2009; 14: 1165–1175.

Wang B, Ling S, Lin WC . 14-3-3Tau regulates Beclin 1 and is required for autophagy. PLoS ONE 2010; 5: e10409.

Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy 2009; 5: 816–823.

Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 2009; 10: 285–292.

Wei Y, Pattingre S, Sinha S, Bassik M, Levine B . JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30: 678–688.

Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P et al. Endogenous HMGB1 regulates autophagy. J Cell Biol 2010; 190: 881–892.

Cherra III SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW et al. Regulation of the autophagy protein LC3 by phosphorylation. J Cell Biol 2010; 190: 533–539.

Shi CS, Kehrl JH . TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 2010; 3: ra42.

Itakura E, Kishi C, Inoue K, Mizushima N . Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19: 5360–5372.

Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T et al. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell 2010; 38: 500–511.

Ciechomska IA, Goemans GC, Skepper JN, Tolkovsky AM . Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function. Oncogene 2009; 28: 2128–2141.

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927–939.

Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. Embo J 2007; 26: 2527–2539.

Sinha S, Levine B . The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 2008; 27 (Suppl 1): S137–S148.

Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF et al. Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. Embo J 2005; 24: 294–304.

Eisenberg-Lerner A, Kimchi A . DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. Cell Death Differ 2007; 14: 1908–1915.

Chang NC, Nguyen M, Germain M, Shore GC . Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. Embo J 2010; 29: 606–618.

Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q . Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 2008; 105: 19211–19216.

Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 2009; 11: 385–396.

Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol 2010; 190: 511–521.

Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH et al. Autophagic and tumour suppressor activity of a novel Beclin 1-binding protein UVRAG. Nat Cell Biol 2006; 8: 688–699.

Knaevelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA et al. UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. Autophagy 2010; 6: 863–870.

Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA et al. Beclin 1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 2008; 10: 776–787.

Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 2007; 9: 1142–1151.

Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009; 11: 468–476.

Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R et al. Ambra1 regulates autophagy and development of the nervous system. Nature 2007; 447: 1121–1125.

Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G, Antonioli M et al. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol 2010; 191: 155–168.

Lotze MT, Tracey KJ . High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5: 331–342.

Tang D, Kang R, Zeh HJ, Lotze MT . HMGB1, oxidative stress, and disease. Antioxid Redox Signal 2010, E-pub ahead of print 24 October 2010, doi:10.1089/ars.2010.3356.

Kang R, Livesey KM, Zeh HJ, Loze MT, Tang D . HMGB1: a novel Beclin 1-binding protein active in autophagy. Autophagy 2010; 6: 1209–1211.

Tang D, Kang R, Cheh CW, Livesey KM, Liang X, Schapiro NE et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 2010; 29: 5299–5310.

Liu L, Yang M, Kang R, Wang Z, Zhao Y, Yu Y et al. HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells. Leukemia 2011; 25: 23–31.

Liu L, Yang M, Kang R, Wang Z, Zhao Y, Yu Y et al. DAMP-mediated autophagy contributes to drug resistance. Autophagy 2010; 7: 112–114.

Scaffidi P, Misteli T, Bianchi ME . Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191–195.

Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P et al. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ 2010; 17: 666–676.

Kang R, Tang D, Lotze MT, Zeh HJ . Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE). Autophagy 2011; 7: 91–93.

Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N . A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 2002; 35: 921–933.

Ropolo A, Grasso D, Pardo R, Sacchetti ML, Archange C, Lo Re A et al. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem 2007; 282: 37124–37133.

Vaccaro MI, Ropolo A, Grasso D, Iovanna JL . A novel mammalian trans-membrane protein reveals an alternative initiation pathway for autophagy. Autophagy 2008; 4: 388–390.

Nowak J, Archange C, Tardivel-Lacombe J, Pontarotti P, Pebusque MJ, Vaccaro MI et al. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell 2009; 20: 870–881.

Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G et al. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol 2010; 11: 920–927.

Vicencio JM, Ortiz C, Criollo A, Jones AW, Kepp O, Galluzzi L et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ 2009; 16: 1006–1017.

Khan MT, Joseph SK . Role of inositol trisphosphate receptors in autophagy in DT40 cells. J Biol Chem 2010; 285: 16912–16920.

Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12: 119–131.

Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R et al. The Parkinson-associated protein PINK1 interacts with Beclin 1 and promotes autophagy. Cell Death Differ 2010; 17: 962–974.

Niu TK, Cheng Y, Ren X, Yang JM . Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis. FEBS Lett 2010; 584: 3519–3524.

Sinha S, Colbert CL, Becker N, Wei Y, Levine B . Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy 2008; 4: 989–997.

Orvedahl A, Alexander D, Talloczy Z, Sun Q, Wei Y, Zhang W et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe 2007; 1: 23–35.

Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol 2009; 186: 255–268.

Gannage M, Dormann D, Albrecht R, Dengjel J, Torossi T, Ramer PC et al. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe 2009; 6: 367–380.

Djavaheri-Mergny M, Maiuri MC, Kroemer G . Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene 2010; 29: 1717–1719.

Luo S, Rubinsztein DC . Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 2010; 17: 268–277.

Hou W, Han J, Lu C, Goldstein LA, Rabinowich H . Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy 2010; 6: 891–900.

Ravikumar B, Futter M, Jahreiss L, Korolchuk VI, Lichtenberg M, Luo S et al. Mammalian macroautophagy at a glance. J Cell Sci 2009; 122 (Part 11): 1707–1711.

Galluzzi L, Morselli E, Kepp O, Marino G, Michaud M, Vitale I et al. Oncosuppressive functions of autophagy. Antioxid Redox Signal 2010, E-pub ahead of print 4 December 2010, doi:10.1089/ars.2010.3478.