The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

International Psychogeriatrics - Tập 21 Số 4 - Trang 672-687 - 2009
Kathryn A. Ellis1,2,3, Ashley I. Bush4,2, David Darby5,6, Daniela De Fazio2, Jonathan K. Foster7,8,9, Peter J. Hudson10, Nicola T. Lautenschlager1,11, Nat Lenzo7,9, Ralph N. Martins7,9, Paul Maruff5,6, Colin L. Masters5,2, Andrew Milner12, Kerryn E. Pike13,2, Christopher Fowler13, Greg Savage14, Cassandra Szoeke10,3, Kevin Taddei7,9, Victor L. Villemagne13, Mark Woodward13, David Ames1,3
1Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St George's Hospital, VictoriaAustralia
2Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
3National Ageing Research Institute, Parkville, Victoria, Australia
4Department of Pathology, University of Melbourne, Victoria, Australia
5Centre for Neuroscience, University of Melbourne, Parkville, Australia
6Cogstate Ltd., Melbourne, Victoria, Australia
7Centre of Excellence for Alzheimer's Disease Research & Care, School of Exercise Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
8Neurosciences Unit, Health Department of Western Australia, Perth, Western Australia, Australia
9Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia
10CSIRO, Parkville, Victoria, Australia
11School of Psychiatry and Clinical Neurosciences and WA Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia.
12Neurosciences Australia, Parkville, Victoria, Australia
13Austin Health, Heidelberg, Victoria, Australia
14Macquarie Centre for Cognitive Science, Macquarie University, NSW, Australia

Tóm tắt

ABSTRACTBackground: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning.Results: A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to comorbid disorders which could affect cognition or because of withdrawal of consent. Participants with AD (211) had neuropsychological profiles which were consistent with AD, and were more impaired than participants with mild cognitive impairment (133) or healthy controls (768), who performed within expected norms for age on neuropsychological testing. PiB PET scans were performed on 287 participants, 100 had DEXA scans and 91 participated in ActiGraph monitoring.Conclusion: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD. They will be reassessed at 18-month intervals in order to determine the predictive utility of various biomarkers, cognitive parameters and lifestyle factors as indicators of AD, and as predictors of future cognitive decline.

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International Psychogeriatrics

Tập 21 Số 4

672-687

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