The Association Between Smoking and Gut Microbiome in Bangladesh

Nicotine and Tobacco Research - Tập 22 Số 8 - Trang 1339-1346 - 2020
Rachel Nolan-Kenney1,2, Fen Wu1,2, Jiyuan Hu1,2, Liying Yang3,4,5, Dervla Kelly6, Huilin Li1,2, Farzana Jasmine7, Muhammad G. Kibriya7, Faruque Parvez8, Ishrat Shaheen9, Golam Sarwar9, Alauddin Ahmed9, Mahbubul Eunus9, Tariqul Islam10, Zhiheng Pei3,4,5, Habibul Ahsan7, Yu Chen1,2
1Department of Environmental Medicine, New York University School of Medicine, New York, NY
2Department of Population Health, New York University School of Medicine, New York, NY
3Department of Medicine, New York University School of Medicine, New York, NY;
4Department of Pathology, New York University School of Medicine, New York, NY
5The Department of Veterans Affairs New York Harbor Healthcare System, New York, NY
6Health Research Institute, Graduate Entry Medical School, University of Limerick, Limerick, Ireland
7Department of Public Health Sciences, Institute for Population and Precision Health, The University of Chicago, Chicago, IL
8Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY
9Department of Informatics, U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh
10Department of Health, Research & Training, U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh

Tóm tắt

AbstractIntroductionEpidemiological studies that investigate alterations in the gut microbial composition associated with smoking are lacking. This study examined the composition of the gut microbiome in smokers compared with nonsmokers.Aims and MethodsStool samples were collected in a cross-sectional study of 249 participants selected from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Microbial DNA was extracted from the fecal samples and sequenced by 16S rRNA gene sequencing. The associations of smoking status and intensity of smoking with the relative abundance or the absence and presence of individual bacterial taxon from phylum to genus levels were examined.ResultsThe relative abundance of bacterial taxa along the Erysipelotrichi-to-Catenibacterium lineage was significantly higher in current smokers compared to never-smokers. The odds ratio comparing the mean relative abundance in current smokers with that in never-smokers was 1.91 (95% confidence interval = 1.36–2.69) for the genus Catenibacterium and 1.89 (95% confidence interval = 1.39–2.56) for the family Erysipelotrichaceae, the order Erysipelotrichale, and the class Erysipelotrichi (false discovery rate-adjusted p values = .0008–.01). A dose–response association was observed for each of these bacterial taxa. The presence of Alphaproteobacteria was significantly greater comparing current with never-smokers (odds ratio = 4.85, false discovery rate-adjusted p values = .04).ConclusionsOur data in a Bangladeshi population are consistent with evidence of an association between smoking status and dosage with change in the gut bacterial composition.ImplicationsThis study for the first time examined the relationship between smoking and the gut microbiome composition. The data suggest that smoking status may play an important role in the composition of the gut microbiome, especially among individuals with higher levels of tobacco exposure.

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Nicotine and Tobacco Research

Tập 22 Số 8

1339-1346

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