The Airway Epithelium is Central to the Pathogenesis of Asthma
Tóm tắt
Từ khóa
Tài liệu tham khảo
Pearce, 2006, How much asthma is really attributable to atopy?, Thorax, 54, 268, 10.1136/thx.54.3.268
Hammad, 2006, Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation, J. AllergyClin. Immunol., 118, 331, 10.1016/j.jaci.2006.03.041
Colognato, 2003, Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells, Blood, 102, 2645, 10.1182/blood-2002-08-2497
Holgate, 2007, The epithelium takes centre stage in asthma and atopic dermatitis, Trends Immunol., 28, 248, 10.1016/j.it.2007.04.007
Allakhverdi, 2007, Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells, J. Exp. Med., 204, 253, 10.1084/jem.20062211
Sha, 2004, Activation of airway epithelial cells by toll-like receptor agonists, Am.J Respir. Cell Mol. Biol., 31, 358, 10.1165/rcmb.2003-0388OC
Holgate, 2006, Rhinoviruses in the pathogenesis of asthma: the bronchial epithelium as a major disease target, J. Allergy Clin. Immunol., 118, 587, 10.1016/j.jaci.2006.06.023
Kato, 2007, TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells, J. Immunol., 179, 1080, 10.4049/jimmunol.179.2.1080
Barbato, 2006, Epithelial damage and angiogenesis in the airways of children with asthma, Am. J. Respir. Crit. Care Med., 174, 975, 10.1164/rccm.200602-189OC
Fedorov, 2005, Epithelial stress and structural remodelling in childhood asthma, Thorax, 60, 389, 10.1136/thx.2004.030262
Bousquet, 2000, Is allergic asthma associated with delayed fetal maturation or the persistence of conserved fetal genes?, Allergy, 55, 1194, 10.1034/j.1398-9995.2000.00923.x
Plopper, 2007, Asthma/ allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?, Toxicol. Pathol., 35, 97, 10.1080/01926230601132030
Davies, 2003, Airway remodeling in asthma: new insights, J. Allergy Clin. Immunol., 111, 215, 10.1067/mai.2003.128
Roche, 1993, Cell adhesion molecules and the bronchial epithelium, Am. Rev. Respir. Dis., 148, S79, 10.1164/ajrccm/148.6_Pt_2.S79
Knight, 2002, Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?, Clin. Exp. Allergy, 32, 1263, 10.1046/j.1365-2745.2002.01486.x
Shahana, 2006, Ultrastructural investigation of epithelial damage in asthmatic and non-asthmatic nasal polyps, Respir. Med., 100, 2018, 10.1016/j.rmed.2006.02.012
Shebani, 2005, Attachment of columnar airway epithelial cells in asthma, Tissue Cell, 37, 145, 10.1016/j.tice.2004.12.002
Bertorelli, 1998, Heat shock protein 70 upregulation is related to HLA-DR expression in bronchial asthma. Effects of inhaled glucocorticoids, Clin. Exp. Allergy, 8, 551, 10.1046/j.1365-2222.1998.00251.x
Bucchieri, 2002, Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis, Am. J. Respir. Cell Mol. Biol., 27, 179, 10.1165/ajrcmb.27.2.4699
Comhair, 2001, Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells, FASEB J., 15, 70, 10.1096/fj.00-0085com
Ercan, 2006, Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma, J. Allergy Clin. Immunol., 118, 1097, 10.1016/j.jaci.2006.08.012
Mak, 2007, Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics, Clin. Exp. Allergy, 37, 1150, 10.1111/j.1365-2222.2007.02704.x
Cohen, 2007, Epithelial cell proliferation contributes to airway remodeling in severe asthma, Am. J. Respir. Crit. Care Med., 176, 138, 10.1164/rccm.200607-1062OC
Truong-Tran, 2002, Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation, Am. J. Respir. Cell Mol. Biol., 27, 286, 10.1165/rcmb.2001-0014OC
Polosa, 2002, Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects, J. Allergy Clin. Immunol., 109, 75, 10.1067/mai.2002.120274
Hamilton, 2005, Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium, Eur. Respir. J., 25, 978, 10.1183/09031936.05.00098604
Hamilton, 2003, The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma, Clin. Exp. Allergy, 33, 233, 10.1046/j.1365-2222.2003.01593.x
Merendino, 2006, CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death, Am. J. Respir. Cell Mol. Biol., 35, 155, 10.1165/rcmb.2005-0433OC
Ritter, 2005, Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly (I: C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response, J. Inflamm. (Lond), 2, 16, 10.1186/1476-9255-2-16
Knight, 2002, Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?, Clin. Exp. Allergy, 32, 1263, 10.1046/j.1365-2745.2002.01486.x
Knight, 2003, The airway epithelium: structural and functional properties in health and disease, Respirology, 8, 432, 10.1046/j.1440-1843.2003.00493.x
lowite, 1989, Permeability of the bronchial mucosa to 99mTc-DTPA in asthma, Am. Rev. Respir. Dis., 139, 1139, 10.1164/ajrccm/139.5.1139
Wan, 2000, Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1, Clin. Exp. Allergy, 30, 685, 10.1046/j.1365-2222.2000.00820.x
Puddicombe, 2003, Increased expression of p21 (waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium, Am. J. Respir. Cell Mol. Biol., 28, 61, 10.1165/rcmb.4715
Chu, 2006, Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells, Am. J. Respir. Cell Mol. Biol., 35, 628, 10.1165/rcmb.2006-0040OC
Kaplan, 2002, Pathways for bradykinin formation and inflammatory disease, J. Allergy Clin. Immunol., 109, 195, 10.1067/mai.2002.121316
Kicic, 2006, Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma, Am. J. Respir. Crit Care Med., 174, 1110, 10.1164/rccm.200603-392OC
Roche, 1989, Subepithelial fibrosis in the bronchi of asthmatics, Lancet, 1, 520, 10.1016/S0140-6736(89)90067-6
Karjalainen, 2003, Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma, Respir. Med., 97, 1045, 10.1016/S0954-6111(03)00136-7
Payne, 2003, Early thickening of the reticular basement membrane in children with difficult asthma, Am. J. Respir. Crit. Care Med., 167, 78, 10.1164/rccm.200205-414OC
Pohunek, 2005, Markers of eosinophilic inflammation and tissue remodelling in children before clinically diagnosed bronchial asthma, Pediatr. Allergy Immunol., 16, 43, 10.1111/j.1399-3038.2005.00239.x
Saglani, 2005, Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction, Am. J. Respir. Crit. Care Med., 171, 722, 10.1164/rccm.200410-1404OC
Ward, 2005, A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients, J. Heart Lung Transplant, 24, 533, 10.1016/j.healun.2004.02.018
Law, 2005, Early changes in basement membrane thickness in airway walls post-lung transplantation, J. Heart Lung Transplant, 24, 1571, 10.1016/j.healun.2005.01.007
Saglani, 2006, Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants, Eur. Respir. J., 28, 505, 10.1183/09031936.06.00056405
Leung, 2006, Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling, J. Pharmacol. Exp. Ther., 319, 586, 10.1124/jpet.106.109314
Locke, 2007, Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease, Am. J. Respir. Cell Mol. Biol., 36, 625, 10.1165/rcmb.2006-0083OC
Zhang, 1999, Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma, Lab. Invest., 79, 395
Choe, 2003, An in vitro airway wall model of remodeling, Am. J. Physiol. Lung Cell Mol. Physiol, 285, L427, 10.1152/ajplung.00005.2003
Phipps, 2004, Acute allergen-induced airway remodeling in atopic asthma, Am. J. Respir. Cell Mol. Biol., 31, 626, 10.1165/rcmb.2004-0193OC
Flood-Page, 2003, Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway, Am. J. Respir. Crit. Care Med., 167, 199, 10.1164/rccm.200208-789OC
Liu, 2002, Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process, J. Immunol., 169, 6459, 10.4049/jimmunol.169.11.6459
Park, 1998, Granulocyte macrophage colony-stimulating factor is the main cytokine enhancing survival of eosinophils in asthmatic airways, Eur. Respir. J., 12, 872, 10.1183/09031936.98.12040872
Leckie, 2000, Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response, Lancet, 356, 2149, 10.1016/S0140-6736(00)03496-6
Kay, 2004, A role for eosinophils in airway remodelling in asthma, Trends Immunol., 25, 477, 10.1016/j.it.2004.07.006
Phipps, 2002, The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin, J. Immunol., 169, 4604, 10.4049/jimmunol.169.8.4604
Kariyawasam, 2007, Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma, Am. J. Respir. Crit. Care Med., 175, 896, 10.1164/rccm.200609-1260OC
Brightling, 2003, Comparison of airway immunopathology of eosinophilic bronchitis and asthma, Thorax, 58, 528, 10.1136/thorax.58.6.528
Lee, 2004, High-resolution CT findings in patients with near-fatal asthma: comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment, Chest, 126, 1840, 10.1016/S0012-3692(15)31431-8
Vignola, 2004, Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD, Eur. Respir. J., 24, 910, 10.1183/09031936.04.00032603
Pepe, 2005, Differences in airway remodeling between subjects with severe and moderate asthma, J. Allergy Clin. Immunol., 116, 544, 10.1016/j.jaci.2005.06.011
Pini, 2007, Differences in proteoglycan deposition in the airways of moderate and severe asthmatics, Eur. Respir. J., 29, 71, 10.1183/09031936.00047905
Park, 1997, High-resolution computed tomography in patients with bronchial asthma: correlation with clinical features, pulmonary functions and bronchial hyperresponsiveness, J. Investig. Allergol. Clin. Immunol., 7, 186
Park, 2006, Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness, Thorax, 61, 41, 10.1136/thx.2005.044420
Shaw, 2004, Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo, Eur. Respir. J., 23, 813, 10.1183/09031936.04.00119904
Willis, 2005, Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta 1: potential role in idiopathic pulmonary fibrosis, Am. J. Pathol., 166, 1321, 10.1016/S0002-9440(10)62351-6
Nihlberg, 2006, Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?, Respir. Res., 7, 50, 10.1186/1465-9921-7-50
Kim, 2006, Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix, Proc. Natl. Acad. Sci. U.S.A., 103, 13180, 10.1073/pnas.0605669103
Wu, 2007, Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse, Respir. Res., 8, 1, 10.1186/1465-9921-8-1
Ward, 2005, Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients, Thorax, 60, 865, 10.1136/thx.2005.043026
Schmidt, 2003, Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma, J. Immunol., 171, 380, 10.4049/jimmunol.171.1.380
Bellini, 2007, The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses, Lab. Invest., 87, 858, 10.1038/labinvest.3700654
Rousseau, 2007, Allelic Association and Recombination Hotspots in the Mucin Gene (MUC) Complex on Chromosome 11p15.5, Ann. Hum. Genet., 71, 561, 10.1111/j.1469-1809.2007.00374.x
Ordonez, 2001, Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression, Am. J. Respir. Crit. Care Med., 163, 517, 10.1164/ajrccm.163.2.2004039
Shimura, 1996, Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma, Eur. Respir. J., 9, 1395, 10.1183/09031936.96.09071395
Rose, 2006, Respiratory tract mucin genes and mucin glycoproteins in health and disease, Physiol. Rev., 86, 245, 10.1152/physrev.00010.2005
Burgel, 2007, A morphometric study of mucins and small airway plugging in cystic fibrosis, Thorax, 62, 153, 10.1136/thx.2006.062190
Deshmukh, 2005, Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation, Am. J. Respir. Crit. Care Med., 171, 305, 10.1164/rccm.200408-1003OC
Lordan, 2002, Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells, J. Immunol., 169, 407, 10.4049/jimmunol.169.1.407
Shao, 2005, Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells, Proc. Natl. Acad. Sci. U.S.A., 102, 767, 10.1073/pnas.0408932102
Elias, 2006, State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice, Proc. Am. Thorac. Soc., 3, 494, 10.1513/pats.200603-068MS
Long, 2006, Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation, Am. J. Respir. Cell Mol. Biol., 35, 357, 10.1165/rcmb.2005-0451OC
Guilbert, 2006, Long-term inhaled corticosteroids in preschool children at high risk for asthma, N. Engl. J. Med., 354, 1985, 10.1056/NEJMoa051378
Murray, 2006, Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study, Lancet, 368, 754, 10.1016/S0140-6736(06)69285-4
Authors Listed, 2000, Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group, N. Engl. J. Med, 343, 1054, 10.1056/NEJM200010123431501
Pauwels, 2003, Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial, Lancet, 361, 1071, 10.1016/S0140-6736(03)12891-7
Holloway, 2005, Identification and function of a novel candidate gene for asthma, Allergol. Int., 54, 25, 10.2332/allergolint.54.25