The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects

Aanerud, 2012, Brain energy metabolism and blood flow differences in healthy aging., J. Cereb. Blood Flow Metab., 32, 1177, 10.1038/jcbfm.2012.18jcbfm201218

Alsop, 2015, Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia., Magn. Reson. Med., 73, 102, 10.1002/mrm.25197

Ambarki, 2015, Accuracy of parenchymal cerebral blood flow measurements using pseudocontinuous arterial spin-labeling in healthy volunteers., AJNR Am. J. Neuroradiol., 36, 1816, 10.3174/ajnr.A4367ajnr.A4367

Asllani, 2009, Separating function from structure in perfusion imaging of the aging brain., Hum. Brain Mapp., 30, 2927, 10.1002/hbm.20719

Asllani, 2008, Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer’s disease., J. Cereb. Blood Flow Metab., 28, 725, 10.1038/sj.jcbfm.9600570

Bangen, 2014, Interactive effects of vascular risk burden and advanced age on cerebral blood flow., Front. Aging Neurosci., 6, 10.3389/fnagi.2014.00159

Bentourkia, 2000, Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging., J. Neurol. Sci., 181, 19, 10.1016/S0022-510X(00)00396-8

Bergfield, 2010, Age-related networks of regional covariance in MRI gray matter: reproducible multivariate patterns in healthy aging., Neuroimage, 49, 1750, 10.1016/j.neuroimage.2009.09.051

Biagi, 2007, Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling., J. Magn. Reson. Imaging, 25, 696, 10.1002/jmri.20839

Birdsill, 2013, Low cerebral blood flow is associated with lower memory function in metabolic syndrome., Obesity, 21, 1313, 10.1002/oby.20170

Brickman, 2007, Structural MRI covariance patterns associated with normal aging and neuropsychological functioning., Neurobiol. Aging, 28, 284, 10.1016/j.neurobiolaging.2005.12.016

Chapman, 2013, Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging., Front. Aging Neurosci., 5, 10.3389/fnagi.2013.00075

Chapman, 2015, Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors., Cereb. Cortex, 25, 396, 10.1093/cercor/bht234bht234

Chen, 2011, Age-associated reductions in cerebral blood flow are independent from regional atrophy., Neuroimage, 55, 468, 10.1016/j.neuroimage.2010.12.032S1053-8119(10)01616-2

Crane, 2015, Gray matter blood flow and volume are reduced in association with white matter hyperintensity lesion burden: a cross-sectional MRI study., Front. Aging Neurosci., 7, 10.3389/fnagi.2015.00131

De Vis, 2015, Age-related changes in brain hemodynamics; a calibrated MRI study., Hum. Brain Mapp., 36, 3973, 10.1002/hbm.22891

De Vis, 2018, Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: A 4-year longitudinal study., J. Magn. Reson. Imaging., 10.1002/jmri.25938

Eidelberg, 2009, Metabolic brain networks in neurodegenerative disorders: a functional imaging approach., Trends Neurosci., 32, 548, 10.1016/j.tins.2009.06.003

Fan, 2016, Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: a systematic review., J. Cereb. Blood Flow Metab., 36, 842, 10.1177/0271678X166363930271678X16636393

Farkas, 2001, Cerebral microvascular pathology in aging and Alzheimer’s disease., Prog. Neurobiol., 64, 575, 10.1016/S0301-0082(00)00068-X

Fleisher, 2009, Cerebral perfusion and oxygenation differences in Alzheimer’s disease risk., Neurobiol. Aging, 30, 1737, 10.1016/j.neurobiolaging.2008.01.012

Gregg, 2015, Incidental cerebral microbleeds cerebral blood flow in elderly individuals., JAMA Neurol., 72, 1021, 10.1001/jamaneurol.2015.13592388928

Habeck, 2008, Multivariate and univariate neuroimaging biomarkers of Alzheimer’s disease., Neuroimage, 40, 1503, 10.1016/j.neuroimage.2008.01.056S1053-8119(08)00102-X

Jagust, 2013, Vulnerable neural systems and the borderland of brain aging and neurodegeneration., Neuron, 77, 219, 10.1016/j.neuron.2013.01.002

Leenders, 1990, Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age., Brain, 113, 27, 10.1093/brain/113.1.27

Liu, 2016, Use of 3D pseudo-continuous arterial spin labeling to characterize sex and age differences in cerebral blood flow., Neuroradiology, 58, 943, 10.1007/s00234-016-1713-y

Liu, 2012, Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics., Magn. Reson. Med., 68, 912, 10.1002/mrm.23286

Lu, 2011, Alterations in cerebral metabolic rate and blood supply across the adult lifespan., Cereb. Cortex, 21, 1426, 10.1093/cercor/bhq224bhq224

Ma, 2010, Parkinson’s disease spatial covariance pattern: noninvasive quantification with perfusion MRI., J. Cereb. Blood Flow Metab., 30, 505, 10.1038/jcbfm.2009.256

Meltzer, 2000, Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction., J. Nucl. Med., 41, 1842

Melzer, 2011, Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease., Brain, 134, 845, 10.1093/brain/awq377awq377

Michels, 2016, Arterial spin labeling imaging reveals widespread and Abeta-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers., J. Cereb. Blood Flow Metab., 36, 581, 10.1177/0271678X15605847

Moeller, 1996, The metabolic topography of normal aging., J. Cereb. Blood Flow Metab., 16, 385, 10.1097/00004647-199605000-00005

Okonkwo, 2014, Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer’s disease., Cereb. Cortex, 24, 978, 10.1093/cercor/bhs381bhs381

Pantano, 1984, Regional cerebral blood flow and oxygen consumption in human aging., Stroke, 15, 635, 10.1161/01.STR.15.4.635

Parkes, 2004, Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects., Magn. Reson. Med., 51, 736, 10.1002/mrm.20023

Petit-Taboue, 1998, Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping., Neuroimage, 7, 176, 10.1006/nimg.1997.0318

Preibisch, 2011, Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling., J. Magn. Reson. Imaging, 34, 1295, 10.1002/jmri.22788

Rane, 2013, Inverse correspondence between hippocampal perfusion and verbal memory performance in older adults., Hippocampus, 23, 213, 10.1002/hipo.22080

Rowe, 2010, Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging., Neurobiol. Aging, 31, 1275, 10.1016/j.neurobiolaging.2010.04.007

Shaw, 1984, Cerebral blood flow changes in benign aging and cerebrovascular disease., Neurology, 34, 855, 10.1212/WNL.34.7.855

Takahashi, 2005, Effects of aging on regional cerebral blood flow assessed by using technetium Tc 99m hexamethylpropyleneamine oxime single-photon emission tomography with 3D stereotactic surface projection analysis., AJNR Am. J. Neuroradiol., 26, 2005

Teune, 2014, Parkinson’s disease-related perfusion and glucose metabolic brain patterns identified with PCASL-MRI and FDG-PET imaging., Neuroimage Clin., 5, 240, 10.1016/j.nicl.2014.06.007

Wagner, 2012, Age-related changes of cerebral autoregulation: new insights with quantitative T2′-mapping and pulsed arterial spin-labeling MR imaging., AJNR Am. J. Neuroradiol., 33, 2081, 10.3174/ajnr.A3138ajnr.A3138

Wierenga, 2013, Interaction of age and APOE genotype on cerebral blood flow at rest., J. Alzheimers Dis., 34, 921, 10.3233/JAD-121897WV08W26393U62134

Wintermark, 2005, Comparative overview of brain perfusion imaging techniques., Stroke, 36, e83, 10.1161/01.STR.0000177839.03321.25

Woodruff-Pak, 2010, Differential effects and rates of normal aging in cerebellum and hippocampus., Proc. Natl. Acad. Sci. U.S.A., 107, 1624, 10.1073/pnas.09142071070914207107

Zhang, 2017, Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer’s disease., Neurosci. Biobehav. Rev., 72, 168, 10.1016/j.neubiorev.2016.11.023

Zlatar, 2014, Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer’s disease., J. Alzheimers Dis., 41, 809, 10.3233/JAD-1322529311J2657G6WHR74

Zuendorf, 2003, Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging., Hum. Brain Mapp., 18, 13, 10.1002/hbm.10069