The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screening

International Journal of Geriatric Psychiatry - Tập 21 Số 11 - Trang 1078-1085 - 2006
Eneida Mioshi1,2, Kate Dawson2, Joanna Mitchell2, Robert Arnold1, John R. Hodges1,2
1MRC Cognition and Brain Sciences Unit, Cambridge, UK
2University of Cambridge Department of Clinical Neurosciences, Addenbrooke's Hospital, Cambridge, UK

Tóm tắt

Abstract

There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE).

Objectives

We aimed to validate an improved revision (the ACE‐R) which incorporates five sub‐domain scores (orientation/attention, memory, verbal fluency, language and visuo‐spatial).

Methods

Standard tests for evaluating dementia screening tests were applied. A total of 241 subjects participated in this study (Alzheimer's disease = 67, frontotemporal dementia = 55, dementia of Lewy Bodies = 20; mild cognitive impairment–MCI = 36; controls = 63).

Results

Reliability of the ACE‐R was very good (alpha coefficient = 0.8). Correlation with the Clinical Dementia Scale was significant (r = −0.321, p < 0.001). Two cut‐offs were defined (88: sensitivity = 0.94, specificity = 0.89; 82: sensitivity = 0.84, specificity = 1.0). Likelihood ratios of dementia were generated for scores between 88 and 82: at a cut‐off of 82 the likelihood of dementia is 100:1. A comparison of individual age and education matched groups of MCI, AD and controls placed the MCI group performance between controls and AD and revealed MCI patients to be impaired in areas other than memory (attention/orientation, verbal fluency and language).

Conclusions

The ACE‐R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction. Copyright © 2006 John Wiley & Sons, Ltd.

Từ khóa


Tài liệu tham khảo

10.1136/jnnp.2003.029595

10.1159/000080965

10.1007/s00415-004-0345-z

10.1001/archneur.58.3.411

10.1017/S0033291703008031

10.1097/00019442-200503000-00007

10.1097/01.wnn.0000182831.47073.e9

10.1002/gps.1450

10.1212/WNL.52.2.224

10.1001/archneur.61.1.59

10.1002/gps.1336

10.1002/gps.1239

10.1212/01.wnl.0000434309.85312.19

McDowell I, 1996, Measuring Health–A Guide to Rating Scales and Questionnaires, 3

10.1212/WNL.54.5.1050

10.1212/WNL.34.7.939

10.1017/S1041610297004870

10.1212/WNL.51.6.1546

Newman J, 2005, Brief Assessment of Cognitive Mental Status in Hebrew: Addenbrooke's Cognitive Examination, Israel Medic Assoc J, 7, 451

10.1001/archneur.56.3.303

Sackett DL, 1991, Clinical Epidemiology – A Basic Science for Clinical Medicine

Sarasola D, 2004, Utilidad del Addenbrooke's Cognitive Examination en Espanol para el Diagnostico de Demencia y para la diferenciacon entre la Enfermedad de Alzheimer y la Demencia Frontotemporal, Revista Argentina de Neuropsicologia, 4, 1

10.1037/0278-7393.6.2.174

Streiner DL, 2003, Health Measurement Scales – A Practical Guide to Their Development and Use, 61, 10.1093/oso/9780198528470.003.0005

Streiner DL, 2003, Health Measurement Scales – A Practical Guide to Their Development and Use, 172, 10.1093/oso/9780198528470.003.0010

Thông tin
Thông tin xuất bản

International Journal of Geriatric Psychiatry

Tập 21 Số 11

1078-1085

Thông tin tác giả