The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screening

International Journal of Geriatric Psychiatry - Tập 21 Số 11 - Trang 1078-1085 - 2006
Eneida Mioshi1,2, Kate Dawson2, Joanna Mitchell2, Robert Arnold1, John R. Hodges1,2
1MRC Cognition and Brain Sciences Unit, Cambridge, UK
2University of Cambridge Department of Clinical Neurosciences, Addenbrooke's Hospital, Cambridge, UK

Tóm tắt

AbstractThere is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE).ObjectivesWe aimed to validate an improved revision (the ACE‐R) which incorporates five sub‐domain scores (orientation/attention, memory, verbal fluency, language and visuo‐spatial).MethodsStandard tests for evaluating dementia screening tests were applied. A total of 241 subjects participated in this study (Alzheimer's disease = 67, frontotemporal dementia = 55, dementia of Lewy Bodies = 20; mild cognitive impairment–MCI = 36; controls = 63).ResultsReliability of the ACE‐R was very good (alpha coefficient = 0.8). Correlation with the Clinical Dementia Scale was significant (r = −0.321, p < 0.001). Two cut‐offs were defined (88: sensitivity = 0.94, specificity = 0.89; 82: sensitivity = 0.84, specificity = 1.0). Likelihood ratios of dementia were generated for scores between 88 and 82: at a cut‐off of 82 the likelihood of dementia is 100:1. A comparison of individual age and education matched groups of MCI, AD and controls placed the MCI group performance between controls and AD and revealed MCI patients to be impaired in areas other than memory (attention/orientation, verbal fluency and language).ConclusionsThe ACE‐R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction. Copyright © 2006 John Wiley & Sons, Ltd.

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Thông tin xuất bản

International Journal of Geriatric Psychiatry

Tập 21 Số 11

1078-1085

Thông tin tác giả