The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Leukemia - Tập 36 Số 7 - Trang 1703-1719 - 2022
Joseph D. Khoury1, Éric Solary2, Oussama Abla3, Yassmine Akkari4, Rita Alaggio5, Jane F. Apperley6, Rafael Bejar7, Emilio Berti8, Lambert Busque9, John K. Chan10, Weina Chen11, Xueyan Chen12, Wee Joo Chng13, John K. Choi14, Isabel Colmenero15, Sarah E. Coupland16, Nicholas C.P. Cross17, Daphne de Jong18, M. Tarek Elghetany19, Emiko Takahashi20, Jean‐François Emile21, Judith A. Ferry22, Linda Fogelstrand23, Michaëla Fontenay24, Ulrich Germing25, Sumeet Gujral26, Torsten Haferlach27, Claire Harrison28, Jennelle C. Hodge29, Shimin Hu1, Joop H. Jansen30, Rashmi Kanagal‐Shamanna1, Hagop M. Kantarjian31, Christian P. Kratz32, Xiaoqiu Li33, Megan S. Lim34, Keith R. Loeb35, Sanam Loghavi1, Andrea N. Marcogliese19, Soheil Meshinchi36, Phillip Michaels37, Kikkeri N. Naresh35, Yasodha Natkunam38, Reza Nejati39, German Ott40, Eric Padron41, Keyur P. Patel1, Nikhil Patkar42, Jennifer Picarsic43, Uwe Platzbecker44, Irene Roberts45, Anna Schuh46, William A. Sewell47, Reiner Siebert48, Prashant Tembhare42, Jeffrey W. Tyner49, Srđan Verstovšek31, Wei Wang1, Brent L. Wood50, Wenbin Xiao51, Cecilia C.S. Yeung35, Andreas Hochhaus52
1Department of Hematopathology; The University of Texas MD Anderson Cancer Center; Houston; TX; USA
2Department of Hematology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France
3Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
4The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH, USA
5Pathology Unit, Department of Laboratories, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy
6Centre for Haematology, Imperial College London, London, UK
7Moores Cancer Center, University of California San Diego, La Jolla, CA, USA
8University of Milan, Fondazione Cà Granda, IRCCS, Ospedale Maggiore Policlinico, Milano, Italy
9Service d’hématologie, oncologie et transplantation, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada
10Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong
11Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
12Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA
13Department of Hematology-Oncology, National University Cancer Institute, Singapore, Singapore
14Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA
15Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
16Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK
17Faculty of Medicine, University of Southampton, Southampton, UK
18Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam, The Netherlands
19Department of Pathology & Immunology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
20Department of Pathology, Aichi Medical University Hospital, Nagakute, Japan
21Department of Pathology, Ambroise Pare Hospital, AP-HP and Versailles SQY University, Boulogne, France
22Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA
23Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg and Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
24Laboratory of Hematology, Assistance Publique-Hôpitaux de Paris, Cochin Hospital and Université Paris Cité, CNRS, INSERM, Cochin Institute, Paris, France
25Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany
26Department of Pathology, Tata Memorial Hospital, Mumbai, India
27MLL Munich Leukemia Laboratory, Munich, Germany
28Department of Haematology, Guys and St Thomas’ NHS Foundation Trust, London, UK
29Indiana University School of Medicine, Indianapolis, IN USA
30Lab Hematology, Dept LABGK, Radboud University Medical Center, Nijmegen, The Netherlands
31Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
32Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
33Departments of Pathology and Oncology, Fudan University, Shanghai, China
34Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA USA
35Section of Pathology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
36Pediatric Hematology and Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
37Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA USA
38Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
39Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA
40Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;
41Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
42Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, India
43Pathology and Lab Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
44Department of Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
45Department of Paediatrics, University of Oxford, Oxford, UK
46Department of Oncology, University of Oxford, Oxford, UK
47Immunology Division, Garvan Institute of Medical Research, Sydney, Australia
48Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany
49Cell, Developmental & Cancer Biology Department, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA
50Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, CA, USA
51Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
52Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany

Tóm tắt

Abstract

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.

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Leukemia

Tập 36 Số 7

1703-1719

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