Tetrahedral framework nucleic acids-based delivery of microRNA-155 inhibits choroidal neovascularization by regulating the polarization of macrophages

Lim, 2012, Age-related macular degeneration, Lancet, 379, 1728, 10.1016/S0140-6736(12)60282-7

Wong, 2014, Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis, Lancet Global Health, 2, e106, 10.1016/S2214-109X(13)70145-1

Friedman, 2004, Prevalence of age-related macular degeneration in the United States, Arch. Ophthalmol., 122, 564, 10.1001/archopht.122.4.564

Hernández-Zimbrón, 2018, Age-related macular degeneration: new paradigms for treatment and management of AMD, Oxid. Med. Cell. Longev., 10.1155/2018/8374647

Augustin, 2009, Inflammation and the pathogenesis of age-related macular degeneration, Expert Opin. Ther. Pat., 13, 641, 10.1517/14728220902942322

Yang, 2016, Macrophage polarization in experimental and clinical choroidal neovascularization, Sci. Rep., 6

Alivernini, 2018, MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis, Front. Immunol., 8, 10.3389/fimmu.2017.01932

Grossniklaus, 2002, Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization, Mol. Vis., 8, 119

Mettu, 2021, Incomplete response to Anti-VEGF therapy in neovascular AMD: exploring disease mechanisms and therapeutic opportunities, Prog. Retin. Eye Res., 82, 10.1016/j.preteyeres.2020.100906

Caicedo, 2005, Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization, Exp. Eye Res., 81, 38, 10.1016/j.exer.2005.01.013

Droho, 2020, Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization, J. Neuroinflammation, 17, e341, 10.1186/s12974-020-02010-0

Sica, 2012, Macrophage plasticity and polarization: in vivo veritas, J. Clin. Invest., 122, 787, 10.1172/JCI59643

Martinez, 2021, MicroRNAs in laser-induced choroidal neovascularization in mice and rats: their expression and potential therapeutic targets, Neur. Regener. Res., 16, 621, 10.4103/1673-5374.295271

Gordon, 2010, Alternative activation of macrophages: mechanism and functions, Immunity, 32, 593, 10.1016/j.immuni.2010.05.007

Parisi, 2018, Macrophage polarization in chronic inflammatory diseases: killers or builders?, J. Immunol. Res., 2018, 10.1155/2018/8917804

Liu, 2013, Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice, PLoS One, 8

He, 2013, Macrophages are essential for the early wound healing response and the formation of a fibrovascular scar, Am. J. Pathol., 182, 2407, 10.1016/j.ajpath.2013.02.032

Brandenburg, 2016, Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors, Acta Neuropathol., 131, 365, 10.1007/s00401-015-1529-6

Supuran, 2019, Agents for the prevention and treatment of age-related macular degeneration and macular edema: a literature and patent review, Expert Opin. Ther. Pat., 29, 761, 10.1080/13543776.2019.1671353

Ardeljan, 2013, Aging is not a disease: distinguishing age-related macular degeneration from aging, Prog. Retin. Eye Res., 37, 68, 10.1016/j.preteyeres.2013.07.003

Suzuki, 2014, Predictive factors for non-response to intravitreal ranibizumab treatment in age-related macular degeneration, Br. J. Ophthalmol., 98, 1186, 10.1136/bjophthalmol-2013-304670

Yang, 2016, Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review, Drug Des. Dev. Ther., 10, 1857

Cui, 2021, Treating LRRK2‐related Parkinson's disease by inhibiting the mTOR signaling pathway to restore autophagy, Adv. Funct. Mater., 2105152, 10.1002/adfm.202105152

Li, 2021, The neuroprotective effect of MicroRNA‐22‐3p modified tetrahedral framework nucleic acids on damaged retinal neurons via TrkB/BDNF signaling pathway, Adv. Funct. Mater., 31, 2104141, 10.1002/adfm.202104141

Fu, 2021, Therapeutic siCCR2 loaded by tetrahedral framework DNA nanorobotics in therapy for intracranial hemorrhage, Adv. Funct. Mater., 2101435, 10.1002/adfm.202101435

Tian, 2021, A framework nucleic acid based robotic nanobee for active targeting therapy, Adv. Funct. Mater., 31, 2007342, 10.1002/adfm.202007342

Li, 2021, Tetrahedral framework nucleic acid-based delivery of resveratrol alleviates insulin resistance: from innate to adaptive immunity, Nano-Micro Lett., 13, 1, 10.1007/s40820-020-00525-y

Gao, 2021, Tetrahedral framework nucleic acids induce immune tolerance and prevent the onset of type 1 diabetes, Nano Lett., 21, 4437, 10.1021/acs.nanolett.1c01131

Zhang, 2021, Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment, Chem. Eng. J., 413, 127426, 10.1016/j.cej.2020.127426

Sun, 2021, Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli (E. coli), Bioact. Mater., 6, 2281, 10.1016/j.bioactmat.2020.12.027

Zhou, 2021, The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions, Bioact. Mater., 6, 1676, 10.1016/j.bioactmat.2020.11.018

Meng, 2021, Aptamer-guided DNA tetrahedrons as a photo-responsive drug delivery system for Mucin 1-expressing breast cancer cells, Appl. Mater. Today, 23, 101010, 10.1016/j.apmt.2021.101010

Zhang, 2020, Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment, Nat. Protoc., 15, 2728, 10.1038/s41596-020-0355-z

Zhu, 2020, Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway, Signal Transd. Target. Thera., 5, 1

Zhang, 2020, Multi-targeted antisense oligonucleotide delivery by a framework nucleic acid for inhibiting biofilm formation and virulence, Nano-Micro Lett., 12, 1, 10.1007/s40820-020-0409-3

Liu, 2020, Tetrahedral framework nucleic acids deliver antimicrobial peptides with improved effects and less susceptibility to bacterial degradation, Nano Lett., 20, 3602, 10.1021/acs.nanolett.0c00529

Sirong, 2020, Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis, Bone Res., 8, 1, 10.1038/s41413-019-0077-4

Zhang, 2022, Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis, Bioact. Mater., 8, 368, 10.1016/j.bioactmat.2021.06.003

Mahesh, 2019, MicroRNA-155: a master regulator of inflammation, J. Interferon Cytokine Res., 39, 321, 10.1089/jir.2018.0155

Ponomarev, 2013, MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS, Glia, 61, 91, 10.1002/glia.22363

Elton, 2013, Regulation of the MIR155 host gene in physiological and pathological processes, Gene, 532, 1, 10.1016/j.gene.2012.12.009

Zhu, 2016, Interleukin-17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization, Immunology, 147, 414, 10.1111/imm.12571

Zhang, 2018, MicroRNA-155 inhibits polarization of macrophages to M2-type and suppresses choroidal neovascularization, Inflammation, 41, 143, 10.1007/s10753-017-0672-8

Martinez, 2021, MicroRNAs in laser-induced choroidal neovascularization in mice and rats: their expression and potential therapeutic targets, Neural Regen. Res., 16, 621, 10.4103/1673-5374.295271

Zhu, 2020, Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway, Signal Transduct. Target. Ther., 5, 1, 10.1038/s41392-020-0173-3

Zhang, 2018, Anti-inflammatory and antioxidative effects of tetrahedral DNA nanostructures via the modulation of macrophage responses, ACS Appl. Mater. Interfaces, 10, 3421, 10.1021/acsami.7b17928

Li, 2019, Advances in biological applications of self-assembled DNA tetrahedral nanostructures, Mater, Today Off., 24, 57

Qin, 2019, Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress: via activating the Akt/Nrf2 pathway, Nanoscale, 11, 20667, 10.1039/C9NR07171G

Fu, 2019, Enhanced efficacy of temozolomide loaded by a tetrahedral framework DNA nanoparticle in the therapy for glioblastoma, ACS Appl. Mater. Interfaces, 11, 39525, 10.1021/acsami.9b13829

Fujio, 2000, Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart, Circulation, 101, 660, 10.1161/01.CIR.101.6.660

Cao, 2013, Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD, Investig. Ophthalmol. Vis. Sci., 54, 3738, 10.1167/iovs.13-11612

Li, 2017, Aptamer-modified tetrahedral DNA nanostructure for tumor-targeted drug delivery, ACS Appl. Mater. Interfaces, 9, 36695, 10.1021/acsami.7b13328

He, 2014, Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization, J. Biol. Chem., 289, 8019, 10.1074/jbc.M113.535765

Zhang, 2020, SARI prevents ocular angiogenesis and inflammation in mice, J. Cell Mol. Med., 24, 4341, 10.1111/jcmm.15096

Parmeggiani, 2010, Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications, Mediat. Inflamm., 2010

Nagai, 2014, Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction, Investig. Ophthalmol. Vis. Sci., 55, 3709, 10.1167/iovs.14-13989

Nowak, 2006, Age-related macular degeneration (AMD): pathogenesis and therapy, Pharmacol. Rep., 58, 353

Chappelow, 2012, Panretinal photocoagulation for proliferative diabetic retinopathy: pattern scan laser versus argon laser, Am. J. Ophthalmol., 153, 137, 10.1016/j.ajo.2011.05.035

Nagineni, 2012, Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration, J. Cell. Physiol., 227, 116, 10.1002/jcp.22708

Lambert, 2013, Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice, Nat. Protoc., 8, 2197, 10.1038/nprot.2013.135

Campos, 2006, A novel imaging technique for experimental choroidal neovascularization, Investig. Ophthalmol. Vis. Sci., 47, 5163, 10.1167/iovs.06-0156

Fukushima, 1997, Comparison of indocyanine green and fluorescein angiography of choroidal neovascularization, Jpn. J. Ophthalmol., 41, 284, 10.1016/S0021-5155(97)00058-0

Xu, 2020, Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway, J. Pineal Res., 69, 10.1111/jpi.12660

Tsutsumi, 2003, The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization, J. Leukoc. Biol., 74, 25, 10.1189/jlb.0902436

Peng, 2018, Mechanism of fibrosis inhibition in laser induced choroidal neovascularization by doxycycline, Exp. Eye Res., 176, 88, 10.1016/j.exer.2018.06.030

Wang, 2019, MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα, Cell Death Dis., 10, 1, 10.1038/s41419-019-2124-x

Li, 2021, Tetrahedral framework nucleic acid-based delivery of resveratrol alleviates insulin resistance: from innate to adaptive immunity, Nano-Micro Lett., 13