Test statistics and sample size formulae for comparative binomial trials with null hypothesis of non‐zero risk difference or non‐unity relative risk

Statistics in Medicine - Tập 9 Số 12 - Trang 1447-1454 - 1990
Paddy Farrington1, George W. Manning2
1PHLS Communicable Disease Surveillance Centre, London, U.K.
2PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, U.K.

Tóm tắt

AbstractWhen it is required to establish a materially significant difference between two treatments, or, alternatively, to show that two treatments are equivalent, standard test statistics and sample size formulae based on a null hypothesis of no difference no longer apply. This paper reviews some of the test statistics and sample size formulae proposed for comparative binomial trials when the null hypothesis is of a specified non‐zero difference or non‐unity relative risk. Methods based on restricted maximum likelihood estimation are recommended and applied to studies of pertussis vaccine.

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Tài liệu tham khảo

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Thông tin xuất bản

Statistics in Medicine

Tập 9 Số 12

1447-1454

Thông tin tác giả