Termination of autophagy and reformation of lysosomes regulated by mTOR

Nature - Tập 465 Số 7300 - Trang 942-946 - 2010
Li Yu1, Christina S. Kary2,3, Lixin Zheng1, Gonzalo A. Mardones4,5, Yueguang Rong6, Junya Peng6, Na Mi6, Ying Zhao7, Zhihua Liu1, Fengyi Wan1, Dale W. Hailey8, Viola Oorschot9, Judith Klumperman9, Eric H. Baehrecke2, Michael J. Lenardo1
1Laboratory of Immunology, National Institute of Allergy, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
2Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605, USA
3Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
4Cell Biology and Metabolism Program, National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA ,
5Department of Physiology, Universidad Austral de Chile, Valdivia 509-9200, Chile
6School of Life Science, Tsinghua University, Beijing 100084, China
7Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China
8Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
9Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Mizushima, N. Autophagy: process and function. Genes Dev. 21, 2861–2873 (2007)

Xie, Z. & Klionsky, D. J. Autophagosome formation: core machinery and adaptations. Nature Cell Biol. 9, 1102–1109 (2007)

Jager, S. et al. Role for Rab7 in maturation of late autophagic vacuoles. J. Cell Sci. 117, 4837–4848 (2004)

Jahreiss, L., Menzies, F. M. & Rubinsztein, D. C. The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic 9, 574–587 (2008)

Kimura, S., Noda, T. & Yoshimori, T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3, 452–460 (2007)

Scott, R. C., Schuldiner, O. & Neufeld, T. P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7, 167–178 (2004)

Wullschleger, S., Loewith, R. & Hall, M. N. TOR signaling in growth and metabolism. Cell 124, 471–484 (2006)

Massey, A. C., Follenzi, A., Kiffin, R., Zhang, C. & Cuervo, A. M. Early cellular changes after blockage of chaperone-mediated autophagy. Autophagy 4, 442–456 (2008)

Mizushima, N. & Kuma, A. Autophagosomes in GFP-LC3 transgenic mice. Methods Mol. Biol. 445, 119–124 (2008)

Dennis, P. B. et al. Mammalian TOR: a homeostatic ATP sensor. Science 294, 1102–1105 (2001)

Ravikumar, B. et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genet. 36, 585–595 (2004)

Sancak, Y. et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496–1501 (2008)

Yu, L., Lenardo, M. J. & Baehrecke, E. H. Autophagy and caspases: a new cell death program. Cell Cycle 3, 1124–1126 (2004)

Yu, L., Strandberg, L. & Lenardo, M. J. The selectivity of autophagy and its role in cell death and survival. Autophagy 4, 567–573 (2008)

Yu, L. et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304, 1500–1502 (2004)

Slot, J. W. & Geuze, H. J. Cryosectioning and immunolabeling. Nature Protocols 2, 2480–2491 (2007)

Bidère, N. et al. Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival. Nature 458, 92–96 (2009)