Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study

The Lancet Oncology - Tập 12 - Trang 361-368 - 2011
Stephen M Ansell1, Hui Tang2, Paul J Kurtin3, Patricia A Koenig4, David J Inwards1, Keith Shah4, Steven C Ziesmer1, Andrew L Feldman3, Radha Rao4, Mamta Gupta1, Charles Erlichman5, Thomas E Witzig1
1Division of Hematology, Mayo Clinic, Rochester, MN, USA
2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA
3Division of Hematopathology, Mayo Clinic, Rochester, MN, USA
4North Central Cancer Treatment Group, Rochester, MN, USA
5Department of Oncology, Mayo Clinic, Rochester, MN, USA

Tài liệu tham khảo

Argatoff, 1997, Mantle cell lymphoma: a clinicopathologic study of 80 cases, Blood, 89, 2067, 10.1182/blood.V89.6.2067 Velders, 1996, Mantle-cell lymphoma: a population-based clinical study, J Clin Oncol, 14, 1269, 10.1200/JCO.1996.14.4.1269 1997, A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project, Blood, 89, 3909, 10.1182/blood.V89.11.3909 Zhou, 2008, Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004, Cancer, 113, 791, 10.1002/cncr.23608 Geisler, 2009, Mantle cell lymphoma—does primary intensive immunochemotherapy improve overall survival for younger patients?, Leuk Lymphoma, 50, 1249, 10.1080/10428190903040030 Herrmann, 2009, Improvement of overall survival in advanced stage mantle cell lymphoma, J Clin Oncol, 27, 511, 10.1200/JCO.2008.16.8435 Geisler, 2008, Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group, Blood, 112, 2687, 10.1182/blood-2008-03-147025 Romaguera, 2010, Ten-year follow-up after intense chemoimmunotherapy with rituximab-HyperCVAD alternating with rituximab-high dose methotrexate/cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma, Br J Haematol, 150, 200 Dietrich, 2010, Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma, Cancer Witzig, 2005, Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma, J Clin Oncol, 23, 5347, 10.1200/JCO.2005.13.466 Ansell, 2008, Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group, Cancer, 113, 508, 10.1002/cncr.23580 Huang, 2003, Rapamycins: mechanism of action and cellular resistance, Cancer Biol Ther, 2, 222, 10.4161/cbt.2.3.360 Dudkin, 2001, Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition, Clin Cancer Res, 7, 1758 Vivanco, 2002, The phosphatidylinositol 3-kinase AKT pathway in human cancer, Nat Rev Cancer, 2, 489, 10.1038/nrc839 Gera, 2004, AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression, J Biol Chem, 279, 2737, 10.1074/jbc.M309999200 Noh, 2004, Determinants of rapamycin sensitivity in breast cancer cells, Clin Cancer Res, 10, 1013, 10.1158/1078-0432.CCR-03-0043 Hidalgo, 2000, The rapamycin-sensitive signal transduction pathway as a target for cancer therapy, Oncogene, 19, 6680, 10.1038/sj.onc.1204091 Farag, 2009, Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma, Leuk Res, 33, 1475, 10.1016/j.leukres.2009.01.039 Hess, 2009, Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma, J Clin Oncol, 27, 3822, 10.1200/JCO.2008.20.7977 Foran, 2000, European phase II study of rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma, J Clin Oncol, 18, 317, 10.1200/JCO.2000.18.2.317 Ghielmini, 2005, Effect of single-agent rituximab given at the standard schedule or as prolonged treatment in patients with mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research (SAKK), J Clin Oncol, 23, 705, 10.1200/JCO.2005.04.164 Coiffier, 1998, Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study, Blood, 92, 1927 Shan, 2000, Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells, Cancer Immunol Immunother, 48, 673, 10.1007/s002620050016 Golay, 2000, Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis, Blood, 95, 3900, 10.1182/blood.V95.12.3900 Wurflein, 1998, Evaluating antibodies for their capacity to induce cell-mediated lysis of malignant B cells, Cancer Res, 58, 3051 Jazirehi, 2004, Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by rituximab, Cancer Res, 64, 7117, 10.1158/0008-5472.CAN-03-3500 Kanelli, 2001, Rituximab toxicity in patients with peripheral blood malignant B-cell lymphocytosis, Leuk Lymphoma, 42, 1329, 10.1080/10428190127502 Cheson, 1999, Report of an international workshop to standardize response criteria for non-Hodgkin's lymphoma, J Clin Oncol, 17, 1244, 10.1200/JCO.1999.17.4.1244 Smith, 2010, Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium, J Clin Oncol, 28, 4740, 10.1200/JCO.2010.29.2813 Gupta, 2009, Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2, Blood, 114, 2926, 10.1182/blood-2009-05-220889