Temporal and spatial variation of the human microbiota during pregnancy

Proceedings of the National Academy of Sciences of the United States of America - Tập 112 Số 35 - Trang 11060-11065 - 2015
Daniel B. DiGiulio1,2,3, Benjamin J. Callahan4,2, Paul J. McMurdie4,2, Elizabeth K. Costello5,6, Deirdre J. Lyell7,2, Anna Robaczewska1,2,3, Christine Sun5,6, Daniela S. Aliaga Goltsman5,6, Ronald J. Wong8,2, Gary M. Shaw8,2, David K. Stevenson8,2, Susan Holmes4,2, David A. Relman1,5,3,9
1Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305
2March of Dimes Prematurity Research Center, Stanford University School of Medicine, Stanford, CA 94305;
3Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304
4Department of Statistics, Stanford University, Stanford, CA 94305;
5Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305;
6eDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305;
7Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford CA 94305
8Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305
9aMarch of Dimes Prematurity Research Center, Stanford University School of Medicine, Stanford, CA 94305;

Tóm tắt

Significance The human indigenous microbial communities (microbiota) play critical roles in health and may be especially important for mother and fetus during pregnancy. Using a case-control cohort of 40 women, we characterized weekly variation in the vaginal, gut, and oral microbiota during and after pregnancy. Microbiota membership remained relatively stable at each body site during pregnancy. An altered vaginal microbial community was associated with preterm birth; this finding was corroborated by an analysis of samples from an additional cohort of nine women. We also discovered an abrupt change in the vaginal microbiota at delivery that persisted in some cases for at least 1 y. Our findings suggest that pregnancy outcomes might be predicted by features of the microbiota early in gestation.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 112 Số 35

11060-11065

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