Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

The Lancet Oncology - Tập 17 Số 11 - Trang 1521-1532 - 2016
Brigitta G. Baumert1,2, Monika E. Hegi3, Martin J. van den Bent4, Andreas von Deimling5, Thierry Gorlia6, Khê Hoang‐Xuan7, Alba A. Brandes8, G. Kantor9, Martin J.B. Taphoorn10,11, Mohamed Ben Hassel12, Christian Hartmann13,5, Gail Ryan14, David Capper5, Johan M. Kros4, Sebastian Kurscheid3,15, Wolfgang Wick5, Roelien H. Enting16, Michele Reni17, Brian Thiessen18, F. Dhermain19, Jacoline E. C. Bromberg4, L. Feuvret7, Jaap C. Reijneveld20, Olivier Chinot21, Johanna M. M. Gijtenbeek22, John P. Rossiter23, Nicolas Dif6, Carmen Balañá24, J M Bravo-Marques25, Paul M. Clément26, Christine Marosi27, Tzahala Tzuk-Shina28, Robert Nordal29, Jeremy Rees30, Denis Lacombe6, Warren Mason31, Roger Stupp3,32
1Maastricht University Medical Centre and GROW (School for Oncology), Maastricht, Netherlands
2MediClin Robert-Janker-Clinic & Clinical Cooperation Unit of Neurooncology, University Bonn Medical Centre, Bonn, Germany
3Lausanne University Hospital, Lausanne, Switzerland
4Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands
5University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany
6European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium
7APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France
8AUSL-IRCCS Scienze Neurologiche, Bologna, Italy
9Institut Bergonié, Comprehensive Cancer Center and University Bordeaux Segalen, Bordeaux, France
10Leiden University Center, Leiden, Netherlands
11Medical Center Haaglanden, The Hague, Netherlands
12Centre Eugène Marquis, Rennes, France
13Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
14Peter MacCallum Cancer Center, Melbourne, VIC, Australia
15The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
16University of Groningen, Groningen, Netherlands
17IRCCS San Raffaele Scientific Institute, Milan, Italy
18BC Cancer Agency, Vancouver, BC, Canada
19Institut Gustave Roussy, Villejuif, France
20VU University Medical Center and Academic Medical Center, Amsterdam, Netherlands
21Aix Marseille, Université, APHM, Hôpital de la Timone, Marseille, France
22Radboud University Medical Center, Nijmegen, Netherlands
23Queen's University, Kingston, ON, Canada
24ICO Badalona Hospital, Germans Trias I Pujol, Barcelona, Spain
25Instituto Portugues de Oncologia de Lisboa, Lisbon, Portugal
26KU Leuven Department of Oncology, Leuven, Belgium
27Medical University of Vienna, Vienna, Austria
28Rambam Health Care Campus, Oncology Institute, Haifa, Israel
29Tom Baker Cancer Center, University of Calgary, Calgary, AB, CANADA
30National Hospital for Neurology and Neurosurgery, London, UK
31Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
32University Hospital Zurich, Zurich, Switzerland

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