Telomere loss: mitotic clock or genetic time bomb?

Mutation Research/DNAging - Tập 256 Số 2-6 - Trang 271-282 - 1991
Calvin B. Harley1
1Department of Biochemistry, McMaster University, Hamilton, Ont. Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Allegra, 1974, In in vivo method of studying the kinetics of cell proliferation in normal human epidermis, Acta Dermatol. (Stockholm), 54, 87

Allshire, 1989, Human telomeres contain at least three types of G-rich repeats distributed non-randomly, Nucleic Acids Res., 17, 4611, 10.1093/nar/17.12.4611

Allsopp, 1991, Telomeres shorten during aging of human fibroblasts in vivo

Baker, 1988, Biomarker of aging, Exp. Gerontol., 23, 223, 10.1016/0531-5565(88)90025-3

Bender, 1989, Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample, Mutation Res., 212, 149, 10.1016/0027-5107(89)90065-1

Benn, 1976, Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos, Am. J. Hum. Genet., 28, 465

Biessmann, 1988, Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster, EMBO J., 7, 1081, 10.1002/j.1460-2075.1988.tb02916.x

Biessmann, 1990, Chromosome ends in Drosophila without telomeric DNA sequences, Proc. Natl. Acad. Sci. (U.S.A.), 87, 1758, 10.1073/pnas.87.5.1758

Blackburn, 1991, Structure and function of telomeres, Nature, 350, 569, 10.1038/350569a0

Blackburn, 1984, The molecular structure of centromeres and telomeres, Annu. Rev. Biochem., 53, 163, 10.1146/annurev.bi.53.070184.001115

Brown, 1989, Molecular cloning of human telomeres in yeast, Nature, 338, 774, 10.1038/338774a0

Chung, 1990, Architectural organization in the interphase nucleus of the protozoan Trypanosoma brucei: location of telomeres and mini-chromosomes, EMBO J., 9, 2611, 10.1002/j.1460-2075.1990.tb07443.x

Cooke, 1986, Variability at the telomeres of human X/Y pseudoautosomal region, 51, 213

Counter, 1991, Maintenance of shortened telomeres in SV40 immortalized human embryonic kidney cells

Cristofalo, 1973, Cellular senescence and DNA synthesis, Exp. Cell Res., 76, 419, 10.1016/0014-4827(73)90394-7

Cross, 1989, Cloning of human telomeres by complementation in yeast, Nature, 338, 771, 10.1038/338771a0

de Lange, 1990, Structure and variability of human chromosome ends, Mol. Cell Biol., 10, 518, 10.1128/MCB.10.2.518

Dell'Orco, 1973, Doubling potential, calendar time, and senescence of human diploid cells in culture, Exp. Cell Res., 77, 356, 10.1016/0014-4827(73)90588-0

Epstein, 1965, Cell renewal in human epidermis, Arch. Dermatol., 92, 462, 10.1001/archderm.1965.01600160118025

Goldstein, 1971, The biology of aging, New Engl. J. Med., 285, 1120, 10.1056/NEJM197111112852005

Goldtein, 1974, Aging in vitro: growth of cultured cells from Galapagos tortoise, Exp. Cell Res., 83, 297, 10.1016/0014-4827(74)90342-5

Goldstein, 1990, Replicative senescence: the human fibroblast comes of age, Science, 249, 1129, 10.1126/science.2204114

Goldstein, 1974, Senescence of cultured human fibroblasts: mitotic versus metabolic time, Exp. Cell Res., 88, 359, 10.1016/0014-4827(74)90252-3

Goldstein, 1978, Chronologic and physiologic area affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors, Science, 199, 781, 10.1126/science.622567

Greider, 1990, Telomeres, telomerase and senescence, BioEssays, 12, 363, 10.1002/bies.950120803

Greider, 1991, Telomeres, Curr. Opin. Cell Biol., 10.1016/0955-0674(91)90072-7

Greider, 1991, Telomerase is processive, Mol. Cell Biol., 10.1128/MCB.11.9.4572

Greider, 1985, Identification of a specfic telomere terminal transferase activity in Tetrahymena extracts, Cell, 43, 405, 10.1016/0092-8674(85)90170-9

Greider, 1987, The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity, Cell, 51, 887, 10.1016/0092-8674(87)90576-9

Greider, 1989, A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis, Nature, 337, 331, 10.1038/337331a0

Harley, 1988, Biology and evolution of aging, Can. J. Aging, 7, 100, 10.1017/S0714980800007340

Harley, 1990, Aging of cultured human skin fibroblasts, Vol. 5, 25

Harley, 1978, Cultured human fibroblasts: distribution of cell generations and a critical limit, J. Cell. Physiol., 97, 509, 10.1002/jcp.1040970326

Harley, 1980, Retesting the commitment theory of cellular aging, Science, 207, 191, 10.1126/science.7350654

Harley, 1990, Telomeres shorten during ageing of human fibroblasts, Nature, 345, 458, 10.1038/345458a0

Hartwell, 1989, Checkpoints: controls that ensure the order of cell cycle events, Science, 246, 629, 10.1126/science.2683079

Hastie, 1990, Telomere reduction in human colorectal carcinoma and with ageing, Nature, 346, 866, 10.1038/346866a0

Hayflick, 1965, The limited in vitro lifetime of human diploid cell strains, Exp. Cell Res., 37, 614, 10.1016/0014-4827(65)90211-9

Hayflick, 1970, Aging under glass, Exp. Gerontol., 5, 291, 10.1016/0531-5565(70)90012-4

Hayflick, 1961, The serial cultivation of human diploid strains, Exp. Cell Res., 25, 585, 10.1016/0014-4827(61)90192-6

Heenen, 1973, Autoradiographic analysis of cell kinetics in human normal epidermis and basal cell carcinoma, Cancer Res., 33, 123

Henderson, 1987, Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs, Cell, 51, 899, 10.1016/0092-8674(87)90577-0

Holliday, 1975, Growth and death of diploid and transformed human fibroblasts, 34, 51

Kipling, 1990, Hypervariable ultra-long telomeres in mice, Nature, 346, 400, 10.1038/347400a0

Kirkwood, 1989, Evolution and ageing, Genome, 31, 398, 10.1139/g89-060

Kohn, 1971

Levis, 1989, Viable deletions of a telomere from a Drosophila chromosome, Cell, 58, 791, 10.1016/0092-8674(89)90112-8

Levy, 1992, Telomere end-replication problem and cellular aging, J. Mol. Biol., 10.1016/0022-2836(92)90096-3

Lundblad, 1990, RNA-dependent polymerase motifs in Est1: Tentative identification of a protein component of an essential yeast telomerase, Cell, 60, 529, 10.1016/0092-8674(90)90653-V

Lundblad, 1989, A mutant with a defect in telomere elongation leads to senescence in yeast, Cell, 57, 633, 10.1016/0092-8674(89)90132-3

Martin, 1970, Replicative life-span of cultivated human cells, Lab. Invest., 23, 86

McClintock, 1941, The stability of broken ends of chromosomes in Zea mays, Genetics, 41, 234, 10.1093/genetics/26.2.234

Meyne, 1989, Conservation of the human telomere sequence (TTAGGG)n among vertebrates, 86, 7049

Morin, 1989, The human telomere terminal transferase is a ribonucleoprotein that synthesizes TTAGGG repeats, Cell, 59, 521, 10.1016/0092-8674(89)90035-4

Moyzis, 1988, A highly conserved repetitive DNA sequence, (TTAGGG)n present at the telomeres of human chromosomes, 85, 6622

Müller, 1938, The remarking of chromosomes, The Collecting Net — Woods Hole, 13, 181

Olovnikov, 1971, Principles of marginotomy in template synthesis of polynucleotides, Dokl. Akad. Nauk. (S.S.S.R.), 201, 1496

Olovnikov, 1973, A theory of Marginotomy, J. Theor. Biol., 41, 181, 10.1016/0022-5193(73)90198-7

Pereira-Smith, 1983, Evidence for the recessive nature fo cellular immortality, Science, 221, 965, 10.1126/science.6879195

Pereira-Smith, 1988, Genetic analysis of indefinite division of human cells: identification of four complementation groups, 85, 6042

Pluta, 1989, Recombination occurs during telomere formation in yeast, Nature, 337, 429, 10.1038/337429a0

Potten, 1988, Epithelial stem cells in vivo, J. Cell. Sci., Suppl., 10, 45, 10.1242/jcs.1988.Supplement_10.4

Radna, 1989, Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature depedent, Mol. Cell. Biol., 9, 3093, 10.1128/MCB.9.7.3093

Rohme, 1981, Evidence for a relatioship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo, 78, 5009

Saksela, 1963, Aneuploidy in the degenerative phase of serial cultivatio of human cell strains, 50, 390

Sen, 1988, Formation of four stranded complexes by guanine-rich mitifs in DNA and its implication for meiosis, Nature, 334, 364, 10.1038/334364a0

Sherwood, 1989, Definite cellular sensecence in IMR-90 cells: a flow cytometric analysis, 85, 9086

Shippen-Lentz, 1989, Telomere terminal transferase activity in the hypotrichous ciliate Eurplotes crassus, Mol. Cell Biol., 9, 2761, 10.1128/MCB.9.6.2761

Staiano-Coico, 1983, Increased sensitvity of lymphocytes from people over 65 to cll cycle arrest and chromosomal damage, Science, 219, 1335, 10.1126/science.6828861

Stanulis-Praeger, 1987, Cellular senescence reivisted: a review, Mech. Ageing Dev., 38, 1, 10.1016/0047-6374(87)90109-6

Starling, 1990, Extensive telomere repeat arrays in mouse are hypervariable, Nucleic Acid. Res., 18, 6881, 10.1093/nar/18.23.6881

Stewart, 1991, Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells, Virology, 180, 49, 10.1016/0042-6822(91)90008-Y

Vaziri, 1991, Telomere length in sperm and its possible role in germ line degeneration in humans with age

Walton, 1982, The role of limited cell replicative capacity in pathological age change: a review, Mech. Aging Dev., 19, 217, 10.1016/0047-6374(82)90056-2

Wang, 1990, Telomere-telomere recombination provides pathway for telomere acquisition, Nature, 345, 456, 10.1038/345456a0

Watson, 1972, Origin of concatameric T4 DNA, Nature new Biol., 239, 197, 10.1038/newbio239197a0

Williams, 1957, Pleiotropy, natural section, and the evolution of senencence, Evolution, 11, 398, 10.2307/2406060

Williamson, 1989, Monovalent cation-induced structure of telomeric DNA: the G-quartet model, Cell, 59, 871, 10.1016/0092-8674(89)90610-7

Wolman, 1964, Early chromosomal changes in SV40-infected human fibroblast cultures, Cytogenetics, 3, 45, 10.1159/000129797

Wright, 1989, Reversible cellular senscence: implications for immortalization of normal human diploid fibroblasts, Mol. Cell. Biol., 9, 3088, 10.1128/MCB.9.7.3088

Yu, 1990, In vivo alteration of telemore sequences and senescence caused by telomerase RNAs, Nature, 44, 126, 10.1038/344126a0

Zahler, 1988, Telomere terminal transferase activity in the hypotrichous ciliate Oxytrichia nova and a model for replication of the ends of linear DNA molecules, Nucliev Acids Res., 16, 6953, 10.1093/nar/16.14.6953

Zakian, 1989, Structure and function of telomeres, Annu. Rev. Genet., 23, 579, 10.1146/annurev.ge.23.120189.003051