Telomere length alterations in microsatellite stable colorectal cancer and association with the immune response

Blasco, 2005, Telomeres and human disease: ageing, cancer and beyond, Nature Reviews, 6, 611, 10.1038/nrg1656 Collins, 2002, Telomerase in the human organism, Oncogene, 21, 564, 10.1038/sj.onc.1205083 Morrish, 2013, Multiple mechanisms contribute to telomere maintenance, Journal of Cancer Biology & Research, 1 Hahn, 2003, Role of telomeres and telomerase in the pathogenesis of human cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol., 21, 2034, 10.1200/JCO.2003.06.018 Henson, 2002, Alternative lengthening of telomeres in mammalian cells, Oncogene, 21, 598, 10.1038/sj.onc.1205058 Engelhardt, 1997, Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer, Clinical Cancer Research: an Official Journal of the American Association for Cancer Research, 3, 1931 Plentz, 2003, Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer, Gut, 52, 1304, 10.1136/gut.52.9.1304 Rampazzo, 2010, Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers, Br. J. Cancer, 102, 1300, 10.1038/sj.bjc.6605644 Maxwell, 2011, Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the pathogenesis of colorectal cancer, Clinical Cancer Research: an Official Journal of the American Association for Cancer Research, 17, 5573, 10.1158/1078-0432.CCR-10-3271 Bertorelle, 2014, Telomeres, telomerase and colorectal cancer, World J. Gastroenterol., 20, 1940, 10.3748/wjg.v20.i8.1940 Pinol-Felis, 2016, Telomeres and telomerase in the clinical management of colorectal cancer, Clinical & Translational Oncology: Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 19, 399, 10.1007/s12094-016-1559-0 Svenson, 2009, Telomere length as a biological marker in malignancy, Biochim. Biophys. Acta, 1792, 317, 10.1016/j.bbadis.2009.01.017 Wang, 2017, Meta-analysis of associations between telomere length and colorectal cancer survival from observational studies, Oncotarget, 8, 62500, 10.18632/oncotarget.20055 Barnes, 2018, The impact of oxidative DNA damage and stress on telomere homeostasis, Mech. Ageing Dev. Mantovani, 2008, Cancer-related inflammation, Nature, 454, 436, 10.1038/nature07205 Francuz, 2016, The role of inflammation in colon cancer pathogenesis, Postepy Hig. Med. Dosw., 70, 360, 10.5604/17322693.1200551 Basu, 2013, Telomeres and telomere dynamics: relevance to cancers of the GI tract, Expert Rev. Gastroenterol. Hepatol., 7, 733, 10.1586/17474124.2013.848790 Shendure, 2004, Advanced sequencing technologies: methods and goals, Nature Reviews, 5, 335, 10.1038/nrg1325 Ding, 2014, Estimating telomere length from whole genome sequence data, Nucleic Acids Res., 42, 10.1093/nar/gku181 Parker, 2012, Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data, Genome Biol., 13, R113, 10.1186/gb-2012-13-12-r113 Sanz-Pamplona, 2014, Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer, Mol. Cancer, 13, 46, 10.1186/1476-4598-13-46 Sanz-Pamplona, 2015, Exome sequencing reveals AMER1 as a frequently mutated gene in colorectal cancer, Clinical Cancer Research: an Official Journal of the American Association for Cancer Research, 21, 4709, 10.1158/1078-0432.CCR-15-0159 Nersisyan, 2015, Computel: computation of mean telomere length from whole-genome next-generation sequencing data, PLoS One, 10, 10.1371/journal.pone.0125201 Lee, 2017, Comparative analysis of whole genome sequencing-based telomere length measurement techniques, Methods, 114, 4, 10.1016/j.ymeth.2016.08.008 Morganella, 2010, VEGA: variational segmentation for copy number detection, Bioinformatics, 26, 3020, 10.1093/bioinformatics/btq586 Alonso, 2017, Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component, Br. J. Cancer, 117, 421, 10.1038/bjc.2017.208 Subramanian, 2007, GSEA-P: a desktop application for gene set enrichment analysis, Bioinformatics, 23, 3251, 10.1093/bioinformatics/btm369 Yoshihara, 2013, Inferring tumour purity and stromal and immune cell admixture from expression data, Nat. Commun., 4, 10.1038/ncomms3612 Guinney, 2015, The consensus molecular subtypes of colorectal cancer, Nat. Med., 21, 1350, 10.1038/nm.3967 Fernandez-Marcelo, 2016, Clinical relevance of telomere status and telomerase activity in colorectal cancer, PLoS One, 11, 10.1371/journal.pone.0149626 Suraweera, 2016, Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer, Oncotarget, 7, 36474, 10.18632/oncotarget.9015 Druliner, 2016, Time lapse to colorectal cancer: telomere dynamics define the malignant potential of polyps, Clinical and Translational Gastroenterology, 7, e188, 10.1038/ctg.2016.48 Valls-Bautista, 2015, In colon cancer, normal colon tissue and blood cells have altered telomere lengths, J. Surg. Oncol., 111, 899, 10.1002/jso.23894 Risques, 2011, Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation, Cancer Res., 71, 1669, 10.1158/0008-5472.CAN-10-1966 Meeker, 2002, Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis, Cancer Res., 62, 6405 Muraki, 2012, Mechanisms of telomere loss and their consequences for chromosome instability, Front. Oncol., 2, 135, 10.3389/fonc.2012.00135 Boardman, 2013, Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer, PLoS One, 8, 10.1371/journal.pone.0080015 Watts, 2016, Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia, Leuk. Res., 49, 62, 10.1016/j.leukres.2016.07.013 Hao, 2013, Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer, Oncol. Rep., 29, 226, 10.3892/or.2012.2098 Nakamura, 2000, Correlation of telomere lengths in normal and cancers tissue in the large bowel, Cancer Lett., 158, 179, 10.1016/S0304-3835(00)00521-8 Falci, 2013, Immune senescence and cancer in elderly patients: results from an exploratory study, Exp. Gerontol., 48, 1436, 10.1016/j.exger.2013.09.011 Qian, 2016, Shorter telomere length of T-cells in peripheral blood of patients with lung cancer, OncoTargets and Therapy, 9, 2675 Guinney, 2015, The consensus molecular subtypes of colorectal cancer, Nat. Med., 21, 1350, 10.1038/nm.3967 Isella, 2015, Stromal contribution to the colorectal cancer transcriptome, Nat. Genet., 47, 312, 10.1038/ng.3224 Jose, 2017, Chronic inflammation in immune aging: role of pattern recognition receptor crosstalk with the telomere complex?, Front. Immunol., 8, 1078, 10.3389/fimmu.2017.01078 Georgin-Lavialle, 2010, The telomere/telomerase system in autoimmune and systemic immune-mediated diseases, Autoimmun. Rev., 9, 646, 10.1016/j.autrev.2010.04.004 Effros, 2011, Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress, Exp. Gerontol., 46, 135, 10.1016/j.exger.2010.08.027 Weng, 2012, Telomeres and immune competency, Curr. Opin. Immunol., 24, 470, 10.1016/j.coi.2012.05.001 Kryston, 2011, Role of oxidative stress and DNA damage in human carcinogenesis, Mutat. Res., 711, 193, 10.1016/j.mrfmmm.2010.12.016 Graham, 2017, Telomeres and telomerase in prostate cancer development and therapy, Nat. Rev. Urol., 14, 607, 10.1038/nrurol.2017.104 Ghosh, 2012, Telomerase directly regulates NF-kappa B-dependent transcription, Nat. Cell Biol., 14, 1270, 10.1038/ncb2621 Jurk, 2014, Chronic inflammation induces telomere dysfunction and accelerates ageing in mice, Nat. Commun., 2, 4172, 10.1038/ncomms5172 Gursel, 2003, Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation, J. Immunol., 171, 1393, 10.4049/jimmunol.171.3.1393 Svenson, 2013, Telomere length in relation to immunological parameters in patients with renal cell carcinoma, PLoS One, 8, 10.1371/journal.pone.0055543 Ben-Baruch, 2006, Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators, Semin. Cancer Biol., 16, 38, 10.1016/j.semcancer.2005.07.006 Yu, 2015, DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function, Cell Rep., 11, 785, 10.1016/j.celrep.2015.03.069 Robin, 2014, Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances, Genes Dev., 28, 2464, 10.1101/gad.251041.114