Targets of horizontal connections in macaque primary visual cortex

Journal of Comparative Neurology - Tập 305 Số 3 - Trang 370-392 - 1991
B A McGuire1, Charles D. Gilbert, Patricia K. Rivlin, TN Wiesel
1Rockefeller University, New York, New York 10021.

Tóm tắt

AbstractPyramidal neurons within the cerebral cortex are known to make long‐range horizontal connections via an extensive axonal collateral system. The synaptic characteristics and specificities of these connections were studied at the ultrastructural level. Two superficial layer pyramidal cells in the primate striate cortex were labeled by intracellular injections with horseradish peroxidase (HRP) and their axon terminals were subsequently examined with the technique of electron microscopic (EM) serial reconstruction. At the light microscopic level both cells showed the characteristic pattern of widespread, clustered axon collaterals. We examined collateral clusters located near the dendritic field (proximal) and approximately 0.5 mm away (distal). The synapses were of the asymmetric/round vesicle variety (type I), and were therefore presumably excitatory. Three‐quarters of the postsynaptic targets were the dendritic spines of other pyramidal cells. A few of the axodendritic synapses were with the shafts of pyramidal cells, bringing the proportion of pyramidal cell targets to 80%. The remaining labeled endings were made with the dendritic shafts of smooth stellate cells, which are presumed to be (GABA)ergic inhibitory cells. On the basis of serial reconstruction of a few of these cells and their dendrites, a likely candidate for one target inhibitory cell is the small‐medium basket cell. Taken together, this pattern of outputs suggests a mixture of postsynaptic effects mediated by monosynaptic excitation followed by combined disynaptic inhibition and excitation. As a consequence the horizontal connections may well be the substrate for the variety of influences observed between the receptive field center and its surround.

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Tài liệu tham khảo

10.1016/0306-4522(77)90074-4

10.1068/p140105

10.1113/jphysiol.1980.sp013435

Anderson J., 1986, The function and intracortical connectivity of a Meynert cell in area 17 of the cat visual cortex, J. Physiol. (Lond.), 371, 41P

10.1002/cne.902310206

10.1113/jphysiol.1973.sp010218

10.1126/science.151.3714.1093

10.1038/320362a0

10.1111/j.1460-9568.1989.tb00794.x

Cajal S. R., 1955, Histologie du Système Nerveux de l'Homme et des Vertébrés

Colonnier M., 1968, Synaptic pattern on different cell types in the different laminae of the cat visual cortex, Brain Res., 9, 258, 10.1016/0006-8993(68)90234-5

Colonnier M., 1981, The Organization of the Cerebral Cortex, 125

10.1016/0306-4522(86)90075-8

10.1002/cne.901940405

Feldman M. L., 1984, Cerebral Cortex. Vol. 1. Cellular components of the cerebral cortex, 123

10.1002/cne.901820510

10.1098/rstb.1975.0099

10.1002/cne.902210303

10.1002/cne.902420209

10.1002/cne.902590305

10.1038/280120a0

Gilbert C. D., 1981, The Organization of the Cerebral Cortex, 163

10.1523/JNEUROSCI.03-05-01116.1983

10.1523/JNEUROSCI.09-07-02432.1989

Gilbert C. D. andWiesel T. N.(1990) The influence of contextual stimuli on the orientation selectivity of cells in primary visual cortex of the cat.Vision Res. in press.

Grinvald A., 1989, Neural Mechanisms of Visual Perception, 117

Hendry S. H. C., 1981, Sizes and distributions of intrinsic neurons incorporating tritiated GABA in monkey sensory‐motor cortex, J. Neurosci., 1, 390, 10.1523/JNEUROSCI.01-04-00390.1981

10.1523/JNEUROSCI.07-05-01503.1987

Hirsch J. A. andC. D.Gilbert(1991) Synaptic physiology of horizontal connections in primary visual cortex.J Neurosci. in press.

10.1016/0306-4522(81)90070-1

10.1002/cne.901600204

Jones E. G., 1984, Cerebral Cortex, Vol. 1, Cellular Components of the Cerebral Cortex, 409

Jones E. G., 1984, Cerebral Cortex, Vol. 1, Cellular Components of the Cerebral Cortex, 309

10.1007/BF00340492

10.1002/cne.902600102

Landry P., 1980, Intracortical distribution of axonal collaterals of pyramidal tract cells in the cat motor cortex, Brain Res., 197, 327, 10.1016/0006-8993(80)91284-6

10.1002/cne.901500104

10.1523/JNEUROSCI.04-01-00309.1984

Lorente de No R., 1949, The Organization of the Cerebral Cortex, 288

10.1002/cne.901470404

10.1002/cne.901590303

10.1113/jphysiol.1984.sp015347

Matsubara J. A., 1987, Anatomical properties and physiological correlates of the intrinsic connections in cat area 18, J. Neurosci., 7, 1428, 10.1523/JNEUROSCI.07-05-01428.1987

McGuire B. A., 1985, Ultrastructural characterization of long‐range clustered horizontal connections in monkey striate cortex, Soc. Neurosci. Abstr., 11, 17

McGuire B. A., 1984, Patterns of synaptic input to layer 4 of cat striate cortex, J. Neurosci., 4, 3021, 10.1523/JNEUROSCI.04-12-03021.1984

10.1016/0006-8993(78)90937-X

10.1007/BF00235620

10.1152/jn.1987.57.6.1792

10.1007/BF00225663

Peters A., 1984, Cellular Components of the Cerebral Cortex, 419

10.1007/BF01173991

10.1126/science.7063863

10.1002/cne.902160307

10.1002/cne.902330205

Sloper J. J., 1979, A qualitative and quantitative electron microscopic study of the neurons in the primate motor and somatic sensory cortices, Phil. Trans. R. Soc. Lond., 285, 141

10.1016/0306-4522(78)90099-4

Somogyi P., 1979, An interneuron making synapses specifically on the axon initial segment (AIS) of pyramidal cells in the cerebral cortex of the cat, J. Physiol. (Lond.), 271, 689

Somogyi P., 1986, Seven distinct types of GABA‐immunoreactive neuron in the visual cortex of cat, Soc. Neurosci. Abstr., 12, 583

10.1016/0306-4522(82)90086-0

10.1523/JNEUROSCI.04-10-02590.1984

10.1016/0306-4522(83)90133-1

Tanaka K., 1983, Cross‐correlation analysis of geniculostriate neuronal relationships in cats, J. Neurophysiol., 49, 1303, 10.1152/jn.1983.49.6.1303

10.1523/JNEUROSCI.06-01-00134.1986

Tombol T., 1978, Some Golgi data on visual cortex of the Rhesus monkey, Acta Morphological Acad. Sci. Hung., 26, 115

10.1152/jn.1981.46.2.191

Toyama K., 1981, Organization of cat visual cortex as investigated by cross‐correlation techniques, J. Neurophysiol., 46, 202, 10.1152/jn.1981.46.2.202

Ts'o D. Y., 1988, The organization of chromatic and spatial interactions in the primate striate cortex, J. Neurosci., 8, 1712, 10.1523/JNEUROSCI.08-05-01712.1988

10.1523/JNEUROSCI.06-04-01160.1986

10.1038/207642a0

Valverde F., 1985, The Cerebral Cortex. Vol. 3. Visual Cortex, 207

Van Essen D. C., 1989, Neural Mechanisms of Visual Perception, 137

10.1016/0304-3940(80)90186-X

10.1002/cne.902620103

Wiesel T. N., 1989, Neural Mechanisms of Visual Perception, 7

10.1016/0306-4522(81)90183-4

Winfield D. A., 1981, The termination of geniculocortical fibres in area 17 of the visual cortex of the macaque monkey, Brain Res., 231, 19, 10.1016/0006-8993(82)90004-X

10.1016/0006-8993(79)90284-1

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Journal of Comparative Neurology

Tập 305 Số 3

370-392

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