Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands
Tài liệu tham khảo
Abascal, 2005, A general purpose model for the condensed phases of water: TIP4P/2005, The Journal of Chemical Physics, 123, 10.1063/1.2121687
Ahmed, 2018, A solution NMR toolset to probe the molecular mechanisms of amyloid inhibitors, Chemical Communications (Cambridge, England), 54, 4644, 10.1039/C8CC01380B
Ambadipudi, 2016, Targeting intrinsically disordered proteins in rational drug discovery, Expert Opinion on Drug Discovery, 11, 65, 10.1517/17460441.2016.1107041
Asthana, 2018, IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies, Biochimica et Biophysica Acta (BBA)—Biomembranes, 1860, 1765, 10.1016/j.bbamem.2018.02.020
Bacia, 2006, Fluorescence cross-correlation spectroscopy in living cells, Nature Methods, 3, 83, 10.1038/nmeth822
Baker, 2014, Insights into the binding of intrinsically disordered proteins from molecular dynamics simulation, Wiley Interdisciplinary Reviews: Computational Molecular Science, 4, 182
Banerjee, 2013, Use of a small peptide fragment as an inhibitor of insulin fibrillation process: A study by high and low resolution spectroscopy, PLoS One, 8, 10.1371/journal.pone.0072318
Barreca, 2018, Pharmacological agents targeting the cellular prion protein, Pathogens, 7, 27, 10.3390/pathogens7010027
Benaki, 2009, Detection of interactions of the beta-amyloid peptide with small molecules employing transferred NOEs, Journal of Peptide Science, 15, 435, 10.1002/psc.1138
Best, 2014, Balanced protein–water interactions improve properties of disordered proteins and non-specific protein association, Journal of Chemical Theory and Computation, 10, 5113, 10.1021/ct500569b
Birol, 2018, Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid, Nature Communications, 9, 1312, 10.1038/s41467-018-03651-9
Bodner, 2010, Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy, Biochemistry, 49, 862, 10.1021/bi901723p
Bonomi, 2010, Enhanced sampling in the well-tempered ensemble, Physical Review Letters, 104, 190601, 10.1103/PhysRevLett.104.190601
Brangwynne, 2015, Polymer physics of intracellular phase transitions, Nature Physics, 11, 899, 10.1038/nphys3532
Breydo, 2012, Alpha-synuclein misfolding and Parkinson's disease, Biochimica et Biophysica Acta, 1822, 261, 10.1016/j.bbadis.2011.10.002
Bulic, 2013, Progress and developments in tau aggregation inhibitors for Alzheimer disease, Journal of Medicinal Chemistry, 56, 4135, 10.1021/jm3017317
Bussi, 2006, Free-energy landscape for beta hairpin folding from combined parallel tempering and metadynamics, Journal of the American Chemical Society, 128, 13435, 10.1021/ja062463w
Caillon, 2016, Molecular structure, membrane interactions, and toxicity of the islet amyloid polypeptide in type 2 diabetes mellitus, Journal of Diabetes Research, 2016, 10.1155/2016/5639875
Chen, 2005, Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils, Journal of Molecular Biology, 354, 760, 10.1016/j.jmb.2005.09.055
Chen, 2012, The use of residual dipolar coupling in studying proteins by NMR, Topics in Current Chemistry, 326, 47, 10.1007/128_2011_215
Comer, 2014, Achieving ergodic sampling using replica-exchange free-energy calculations, Molecular Simulation, 40, 218, 10.1080/08927022.2013.841909
Daura, 1999, Validation of molecular simulation by comparison with experiment: Rotational reorientation of tryptophan in water, The Journal of Chemical Physics, 110, 3049, 10.1063/1.477900
Dong, 2018, Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils, Biochimica et Biophysica Acta, 1860, 1826, 10.1016/j.bbamem.2018.03.006
Dundr, 2012, Nuclear bodies: Multifunctional companions of the genome, Current Opinion in Cell Biology, 24, 415, 10.1016/j.ceb.2012.03.010
Elbaum-Garfinkle, 2015, The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics, Proceedings of the National Academy of Sciences of the United States of America, 112, 7189, 10.1073/pnas.1504822112
Estrada-Ortiz, 2016, How to design a successful p53-MDM2/X interaction inhibitor: A thorough overview based on crystal structures, ChemMedChem, 11, 757, 10.1002/cmdc.201500487
Fawzi, 2010, Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation, Journal of the American Chemical Society, 132, 9948, 10.1021/ja1048253
Fawzi, 2012, Probing exchange kinetics and atomic resolution dynamics in high-molecular-weight complexes using dark-state exchange saturation transfer NMR spectroscopy, Nature Protocols, 7, 1523, 10.1038/nprot.2012.077
Ferguson, 1995, Parameterization and evaluation of a flexible water model, Journal of Computational Chemistry, 16, 501, 10.1002/jcc.540160413
Ferreon, 2009, Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence, Proceedings of the National Academy of Sciences of the United States of America, 106, 5645, 10.1073/pnas.0809232106
Fichou, 2018, Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments, Chemical Communications (Cambridge), 54, 4573, 10.1039/C8CC01355A
Fisher, 2011, Constructing ensembles for intrinsically disordered proteins, Current Opinion in Structural Biology, 21, 426, 10.1016/j.sbi.2011.04.001
Frankel, 2016, Polyamine/nucleotide coacervates provide strong compartmentalization of Mg2+, nucleotides, and RNA, Langmuir, 32, 2041, 10.1021/acs.langmuir.5b04462
Fung, 2018, IDPs in macromolecular complexes: The roles of multivalent interactions in diverse assemblies, Current Opinion in Structural Biology, 49, 36, 10.1016/j.sbi.2017.12.007
Fusco, 2017, Structural basis of membrane disruption and cellular toxicity by alpha-synuclein oligomers, Science, 358, 1440, 10.1126/science.aan6160
Fusco, 2018, Order and disorder in the physiological membrane binding of alpha-synuclein, Current Opinion in Structural Biology, 48, 49, 10.1016/j.sbi.2017.09.004
Galkin, 2002, Liquid–liquid separation in solutions of normal and sickle cell hemoglobin, Proceedings of the National Academy of Sciences of the United States of America, 99, 8479, 10.1073/pnas.122055299
Galvagnion, 2016, Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of alpha-synuclein, Proceedings of the National Academy of Sciences of the United States of America, 113, 7065, 10.1073/pnas.1601899113
Ge, 2009, In vivo formation of protein based aqueous microcompartments, Journal of the American Chemical Society, 131, 9094, 10.1021/ja902890r
Haney, 2017, Site-specific fluorescence polarization for studying the disaggregation of alpha-synuclein fibrils by small molecules, Biochemistry, 56, 683, 10.1021/acs.biochem.6b01060
Hanwell, 2012, Avogadro: An advanced semantic chemical editor, visualization, and analysis platform, Journal of Cheminformatics, 4, 17, 10.1186/1758-2946-4-17
Haustein, 2007, Fluorescence correlation spectroscopy: Novel variations of an established technique, Annual Review of Biophysics and Biomolecular Structure, 36, 151, 10.1146/annurev.biophys.36.040306.132612
Hebda, 2009, A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes, Chemistry & Biology, 16, 943, 10.1016/j.chembiol.2009.08.013
Heller, 2017, Methods of probing the interactions between small molecules and disordered proteins, Cellular and Molecular Life Sciences, 74, 3225, 10.1007/s00018-017-2563-4
Henriques, 2016, Molecular dynamics simulations of intrinsically disordered proteins: On the accuracy of the TIP4P-D water model and the representativeness of protein disorder models, Journal of Chemical Theory and Computation, 12, 3407, 10.1021/acs.jctc.6b00429
Hong, 2008, Structural characteristics of α-synuclein oligomers stabilized by the flavonoid baicalein, Journal of Molecular Biology, 383, 214, 10.1016/j.jmb.2008.08.039
Hoppener, 2000, Islet amyloid and type 2 diabetes mellitus, The New England Journal of Medicine, 343, 411, 10.1056/NEJM200008103430607
Huang, 2017, CHARMM36m: An improved force field for folded and intrinsically disordered proteins, Nature Methods, 14, 71, 10.1038/nmeth.4067
Hülsmann, 2012, The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model, Cell, 150, 738, 10.1016/j.cell.2012.07.019
Humphrey, 1996, VMD: Visual molecular dynamics, Journal of Molecular Graphics, 14, 33, 10.1016/0263-7855(96)00018-5
Iljina, 2016, Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading, Proceedings of the National Academy of Sciences of the United States of America, 113, E1206, 10.1073/pnas.1524128113
Ittner, 2011, Amyloid-beta and tau—A toxic pas de deux in Alzheimer's disease, Nature Reviews. Neuroscience, 12, 65, 10.1038/nrn2967
Joshi, 2016, A fragment-based method of creating small-molecule libraries to target the aggregation of intrinsically disordered proteins, ACS Combinatorial Science, 18, 144, 10.1021/acscombsci.5b00129
Joshi, 2015, Druggability of intrinsically disordered proteins, Advances in Experimental Medicine and Biology, 870, 383, 10.1007/978-3-319-20164-1_13
Kachala, 2015, Application of SAXS for the structural characterization of IDPs, Advances in Experimental Medicine and Biology, 870, 261, 10.1007/978-3-319-20164-1_8
Kaffy, 2016, Designed glycopeptidomimetics disrupt protein–protein interactions mediating amyloid β-peptide aggregation and restore neuroblastoma cell viability, Journal of Medicinal Chemistry, 59, 2025, 10.1021/acs.jmedchem.5b01629
Kikhney, 2015, A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins, FEBS Letters, 589, 2570, 10.1016/j.febslet.2015.08.027
Kleckner, 2011, An introduction to NMR-based approaches for measuring protein dynamics, Biochimica et Biophysica Acta, 1814, 942, 10.1016/j.bbapap.2010.10.012
Kolarova, 2012, Structure and pathology of tau protein in Alzheimer disease, International Journal of Alzheimer's Disease, 2012, 731526, 10.1155/2012/731526
Krebs, 2005, The binding of thioflavin-T to amyloid fibrils: Localisation and implications, Journal of Structural Biology, 149, 30, 10.1016/j.jsb.2004.08.002
Kumar, 2016, Foldamer-mediated manipulation of a pre-amyloid toxin, Nature Communications, 7, 10.1038/ncomms11412
Kumar, 2018, Peptidomimetic-based multi-domain targeting offers critical evaluation of Abeta structure and toxic function, Journal of the American Chemical Society, 140, 6562, 10.1021/jacs.7b13401
Kumar, 2017, Foldamer-mediated structural rearrangement attenuates Abeta oligomerization and cytotoxicity, Journal of the American Chemical Society, 139, 17098, 10.1021/jacs.7b08259
Kumar, 2015, Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based alpha-helical mimetics, Chemistry & Biology, 22, 369, 10.1016/j.chembiol.2015.01.006
Laghaei, 2011, Structure and thermodynamics of amylin dimer studied by Hamiltonian-temperature replica exchange molecular dynamics simulations, Journal of Physical Chemistry B, 115, 3146, 10.1021/jp108870q
Lee, 2012, Understanding pre-structured motifs (PreSMos) in intrinsically unfolded proteins, Current Protein & Peptide Science, 13, 34, 10.2174/138920312799277974
Lee, 2015, Probing protein disorder and complexity at single-molecule resolution, Seminars in Cell & Developmental Biology, 37, 26, 10.1016/j.semcdb.2014.09.027
Lee, 2017, Towards an understanding of amyloid-beta oligomers: Characterization, toxicity mechanisms, and inhibitors, Chemical Society Reviews, 46, 310, 10.1039/C6CS00731G
Lendel, 2009, On the mechanism of nonspecific inhibitors of protein aggregation: Dissecting the interactions of alpha-synuclein with Congo red and lacmoid, Biochemistry, 48, 8322, 10.1021/bi901285x
Levine, 2015, Regulation and aggregation of intrinsically disordered peptides, Proceedings of the National Academy of Sciences of the United States of America, 112, 2758, 10.1073/pnas.1418155112
Levine, 2016, Surface force measurements and simulations of mussel-derived peptide adhesives on wet organic surfaces, Proceedings of the National Academy of Sciences, 113, 4332, 10.1073/pnas.1603065113
Li, 2012, Phase transitions in the assembly of multivalent signalling proteins, Nature, 483, 336, 10.1038/nature10879
Li, 2004, Dopamine and L-dopa disaggregate amyloid fibrils: Implications for Parkinson's and Alzheimer's disease, The FASEB Journal, 18, 962, 10.1096/fj.03-0770fje
Liu, 2014, Advantages of proteins being disordered, Protein Science, 23, 539, 10.1002/pro.2443
Lopez del Amo, 2012, Structural properties of EGCG-induced, nontoxic Alzheimer's disease Abeta oligomers, Journal of Molecular Biology, 421, 517, 10.1016/j.jmb.2012.01.013
Lyons, 2014, Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment, Proteins: Structure, Function, and Bioinformatics, 82, 1907, 10.1002/prot.24544
Ma, 2002, Multiple diverse ligands binding at a single protein site: A matter of pre-existing populations, Protein Science: A Publication of the Protein Society, 11, 184, 10.1110/ps.21302
Ma, 2016, Dancing with strings: The conformational dynamics of VQIXXK motifs within tau protein in monomer, fibril and hyper-phosphorylated filament states, Biophysical Journal, 110, 553a, 10.1016/j.bpj.2015.11.2960
Maltsev, 2012, Monomeric alpha-synuclein binds Congo red micelles in a disordered manner, Biochemistry, 51, 631, 10.1021/bi201435d
Marasco, 2015, Identification of inhibitors of biological interactions involving intrinsically disordered proteins, International Journal of Molecular Sciences, 16, 7394, 10.3390/ijms16047394
Mark, 2005, Characterization of segments from the central region of BRCA1: An intrinsically disordered scaffold for multiple protein–protein and protein–DNA interactions?, Journal of Molecular Biology, 345, 275, 10.1016/j.jmb.2004.10.045
Marsh, 2012, Ensemble modeling of protein disordered states: Experimental restraint contributions and validation, Proteins, 80, 556, 10.1002/prot.23220
Melo, 2016, A functional role for intrinsic disorder in the tau-tubulin complex, Proceedings of the National Academy of Sciences of the United States of America, 113, 14336, 10.1073/pnas.1610137113
Metallo, 2010, Intrinsically disordered proteins are potential drug targets, Current Opinion in Chemical Biology, 14, 481, 10.1016/j.cbpa.2010.06.169
Meyer, 2003, NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors, Angewandte Chemie (International Ed. in English), 42, 864, 10.1002/anie.200390233
Milles, 2012, Intramolecular three-colour single pair FRET of intrinsically disordered proteins with increased dynamic range, Molecular BioSystems, 8, 2531, 10.1039/c2mb25135c
Mohan, 2006, Analysis of molecular recognition features (MoRFs), Journal of Molecular Biology, 362, 1043, 10.1016/j.jmb.2006.07.087
Moree, 2015, Small molecules detected by second-harmonic generation modulate the conformation of monomeric alpha-synuclein and reduce its aggregation in cells, The Journal of Biological Chemistry, 290, 27582, 10.1074/jbc.M114.636027
Naiki, 1989, Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T, Analytical Biochemistry, 177, 244, 10.1016/0003-2697(89)90046-8
Nott, 2016, Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters, Nature Chemistry, 8, 569, 10.1038/nchem.2519
Ouberai, 2013, Alpha-synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling, The Journal of Biological Chemistry, 288, 20883, 10.1074/jbc.M113.478297
Overbeek, 1957, Phase separation in polyelectrolyte solutions. Theory of complex coacervation, Journal of Cellular and Comparative Physiology, 49, 7, 10.1002/jcp.1030490404
Pak, 2016, Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein, Molecular Cell, 63, 72, 10.1016/j.molcel.2016.05.042
Perni, 2017, A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity, Proceedings of the National Academy of Sciences of the United States of America, 114, E1009, 10.1073/pnas.1610586114
Pithadia, 2016, Inhibition of IAPP aggregation and toxicity by natural products and derivatives, Journal of Diabetes Research, 2016, 10.1155/2016/2046327
Post, 2003, Exchange-transferred NOE spectroscopy and bound ligand structure determination, Current Opinion in Structural Biology, 13, 581, 10.1016/j.sbi.2003.09.012
Prakash, 2011, Replica temperatures for uniform exchange and efficient roundtrip times in explicit solvent parallel tempering simulations, Journal of Chemical Theory and Computation, 7, 2025, 10.1021/ct200208h
Qin, 2017, Protein folding, binding, and droplet formation in cell-like conditions, Current Opinion in Structural Biology, 43, 28, 10.1016/j.sbi.2016.10.006
Rahimi, 2018, Aptamers selected for recognizing amyloid beta-protein—A case for cautious optimism, International Journal of Molecular Sciences, 19, 668, 10.3390/ijms19030668
Rauscher, 2015, Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment, Journal of Chemical Theory and Computation, 11, 5513, 10.1021/acs.jctc.5b00736
Rauscher, 2017, The liquid structure of elastin, eLife, 6, e26526, 10.7554/eLife.26526
Rawat, 2018, Membranes as modulators of amyloid protein misfolding and target of toxicity, Biochimica et Biophysica Acta (BBA)—Biomembranes, 1860, 1863, 10.1016/j.bbamem.2018.04.011
Rhoades, 2006, Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy, Biophysical Journal, 90, 4692, 10.1529/biophysj.105.079251
Ronga, 2006, The prion protein: Structural features and related toxic peptides, Chemical Biology & Drug Design, 68, 139, 10.1111/j.1747-0285.2006.00427.x
Rosborough, 2017, Alpha-synuclein and parkinsonism: Updates and future perspectives, Current Neurology and Neuroscience Reports, 17, 31, 10.1007/s11910-017-0737-y
Sandberg, 2010, Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering, Proceedings of the National Academy of Sciences of the United States of America, 107, 15595, 10.1073/pnas.1001740107
Sasahara, 2018, Membrane-mediated amyloid deposition of human islet amyloid polypeptide, Biophysical Reviews, 10, 453, 10.1007/s12551-017-0351-x
Saunders, 2016, An in vivo platform for identifying inhibitors of protein aggregation, Nature Chemical Biology, 12, 94, 10.1038/nchembio.1988
Schiro, 2015, Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins, Nature Communications, 6, 6490, 10.1038/ncomms7490
Schlamadinger, 2014, Fiber-dependent and -independent toxicity of islet amyloid polypeptide, Biophysical Journal, 107, 2559, 10.1016/j.bpj.2014.09.047
Schmidt, 2015, Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity, eLife, 4, 10.7554/eLife.04251
Schuler, 2013, Single-molecule FRET of protein structure and dynamics—A primer, Journal of Nanbiotechnology, 11, S2, 10.1186/1477-3155-11-S1-S2
Schuler, 2008, Protein folding studied by single-molecule FRET, Current Opinion in Structural Biology, 18, 16, 10.1016/j.sbi.2007.12.003
Sekhar, 2013, NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers, Proceedings of the National Academy of Sciences of the United States of America, 110, 12867, 10.1073/pnas.1305688110
Sezgin, 2012, Elucidating membrane structure and protein behavior using giant plasma membrane vesicles, Nature Protocols, 7, 1042, 10.1038/nprot.2012.059
Shammas, 2015, A mechanistic model of tau amyloid aggregation based on direct observation of oligomers, Nature Communications, 6, 7025, 10.1038/ncomms8025
Sharma, 2018, MoRFPred-plus: Computational identification of MoRFs in protein sequences using physicochemical properties and HMM profiles, Journal of Theoretical Biology, 437, 9, 10.1016/j.jtbi.2017.10.015
Shea, 2016, Studying the early stages of protein aggregation using replica exchange molecular dynamics simulations, Methods in Molecular Biology, 1345, 225, 10.1007/978-1-4939-2978-8_15
Shields, 1983, An introduction to ergodic-theory—Walters, P, Bulletin of the American Mathematical Society, 9, 259, 10.1090/S0273-0979-1983-15179-0
Shoemaker, 2000, Speeding molecular recognition by using the folding funnel: The fly-casting mechanism, Proceedings of the National Academy of Sciences, 97, 8868, 10.1073/pnas.160259697
Srivastava, 2010, Identifying the bond responsible for the fluorescence modulation in an amyloid fibril sensor, Chemistry, 16, 9257, 10.1002/chem.200902968
Sugita, 1999, Replica-exchange molecular dynamics method for protein folding, Chemical Physics Letters, 314, 141, 10.1016/S0009-2614(99)01123-9
Tantos, 2012, Identification of intrinsically disordered proteins by a special 2D electrophoresis, Methods in Molecular Biology, 896, 215, 10.1007/978-1-4614-3704-8_13
Theillet, 2014, Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs), Chemical Reviews, 114, 6661, 10.1021/cr400695p
Toth, 2014, Targeting the intrinsically disordered structural ensemble of alpha-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease, PLoS One, 9, 10.1371/journal.pone.0087133
Trexler, 2009, Alpha-synuclein binds large unilamellar vesicles as an extended helix, Biochemistry, 48, 2304, 10.1021/bi900114z
Uversky, 2012, Size-exclusion chromatography in structural analysis of intrinsically disordered proteins, 179
Uversky, 2013, Intrinsic disorder-based protein interactions and their modulators, Current Pharmaceutical Design, 19, 4191, 10.2174/1381612811319230005
Uversky, 2015, Proteins without unique 3D structures: Biotechnological applications of intrinsically unstable/disordered proteins, Biotechnology Journal, 10, 356, 10.1002/biot.201400374
Uversky, 2016, p53 proteoforms and intrinsic disorder: An illustration of the protein structure–function continuum concept, International Journal of Molecular Sciences, 17, 1874, 10.3390/ijms17111874
Uversky, 2017, Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder, Current Opinion in Structural Biology, 44, 18, 10.1016/j.sbi.2016.10.015
Uversky, 2017, Paradoxes and wonders of intrinsic disorder: Stability of instability, Intrinsically Disordered Proteins, 5, 10.1080/21690707.2017.1327757
Uversky, 2000, Why are “natively unfolded” proteins unstructured under physiologic conditions?, Proteins: Structure, Function, and Bioinformatics, 41, 415, 10.1002/1097-0134(20001115)41:3<415::AID-PROT130>3.0.CO;2-7
Uversky, 2015, Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates, FEBS Letters, 589, 15, 10.1016/j.febslet.2014.11.028
Uversky, 2008, Intrinsically disordered proteins in human diseases: Introducing the D2 concept, Annual Review of Biophysics, 37, 215, 10.1146/annurev.biophys.37.032807.125924
van der Lee, 2014, Classification of intrinsically disordered regions and proteins, Chemical Reviews, 114, 6589, 10.1021/cr400525m
Voropai, 2003, Spectral properties of thioflavin T and its complexes with amyloid fibrils, Journal of Applied Spectroscopy, 70, 868, 10.1023/B:JAPS.0000016303.37573.7e
Wang, 2011, Novel strategies for drug discovery based on intrinsically disordered proteins (IDPs), International Journal of Molecular Sciences, 12, 3205, 10.3390/ijms12053205
Wang, 2010, Phase behavior of mixtures of human lens proteins gamma D and beta B1, Proceedings of the National Academy of Sciences, 107, 13282, 10.1073/pnas.1008353107
Weber, 2017, How accurate are your simulations? Effects of confined aqueous volume and AMBER FF99SB and CHARMM22/CMAP force field parameters on structural ensembles of intrinsically disordered proteins: Amyloid-β42 in water, Intrinsically Disordered Proteins, 5, 10.1080/21690707.2017.1377813
Wegmann, 2018, Tau protein liquid–liquid phase separation can initiate tau aggregation, The EMBO Journal, 37, 10.15252/embj.201798049
Wells, 2008, Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain, Proceedings of the National Academy of Sciences of the United States of America, 105, 5762, 10.1073/pnas.0801353105
Wright, 2009, Linking folding and binding, Current Opinion in Structural Biology, 19, 31, 10.1016/j.sbi.2008.12.003
Wright, 2014, Intrinsically disordered proteins in cellular signalling and regulation, Nature Reviews Molecular Cell Biology, 16, 18, 10.1038/nrm3920
Xue, 2012, Orderly order in protein intrinsic disorder distribution: Disorder in 3500 proteomes from viruses and the three domains of life, Journal of Biomolecular Structure & Dynamics, 30, 137, 10.1080/07391102.2012.675145
Young, 2015, Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry, Nature Chemistry, 7, 73, 10.1038/nchem.2129
Zerze, 2015, Sequence- and temperature-dependent properties of unfolded and disordered proteins from atomistic simulations, Journal of Physical Chemistry B, 119, 14622, 10.1021/acs.jpcb.5b08619
Zerze, 2015, Free energy surface of an intrinsically disordered protein: Comparison between temperature replica exchange molecular dynamics and bias-exchange metadynamics, Journal of Chemical Theory and Computation, 11, 2776, 10.1021/acs.jctc.5b00047
Zerze, 2015, To what extent does surface hydrophobicity dictate peptide folding and stability near surfaces?, Langmuir, 31, 12223, 10.1021/acs.langmuir.5b03814
Zhang, 2015, Small-molecule MDM2-p53 inhibitors: Recent advances, Future Medicinal Chemistry, 7, 631, 10.4155/fmc.15.13
Zhang, 2017, Membrane interactions of hIAPP monomer and oligomer with lipid membranes by molecular dynamics simulations, ACS Chemical Neuroscience, 8, 1789, 10.1021/acschemneuro.7b00160
Aguzzi, 2016, Phase separation: Linking cellular compartmentalization to disease, Trends in Cell Biology, 26, 547, 10.1016/j.tcb.2016.03.004
Elbaum-Garfinkle, 2015, Liquids, fibers, and gels: The many phases of neurodegeneration, Developmental Cell, 35, 531, 10.1016/j.devcel.2015.11.014
Kaibara, 1992, α-Elastin coacervate as a protein liquid membrane: Effect of pH on transmembrane potential responses, Biopolymers, 32, 1173, 10.1002/bip.360320906
Wang, 2017, Liquid–liquid phase separation in oligomeric peptide solutions, Langmuir, 33, 7715, 10.1021/acs.langmuir.7b01693
