Targeting pCO2 in Asthma: Pilot Evaluation of a Capnometry-Assisted Breathing Training

Abelson, J. L., Weg, J. G., Nesse, R. M., et al. (2001). Persistent respiratory irregularity in patients with panic disorder. Biological Psychiatry, 49, 588–595.

Berg, J., Dunbar-Jacob, J., & Rohay, J. M. (1998). Compliance with inhaled medications: the relationship between diary and electronic monitor. Annals of Behavioral Medicine, 20, 36–38.

Bernardi, L., Porta, C., Spicuzza, L., et al. (2002). Slow breathing increases arterial baroreflex sensitivity in patients with chronic heart failure. Circulation, 15(105), 143–145.

Bernardi, L., Spadacini, G., Bellwon, J., et al. (1998). Effect of breathing rate on oxygen saturation and exercise performance in chronic heart failure. Lancet, 351, 1308–1311.

Bowler, S. D., Green, A. G., & Mitchell, C. A. (1998). Buteyko breathing techniques in asthma: A blinded randomised controlled trial. Medical Journal of Australia, 169, 575–578.

Bruton, A., & Holgate, S. T. (2005). Hypocapnia and asthma: a mechanism for breathing retraining? Chest, 127, 1808–1811.

Carr, R. E. (1998). Panic disorder and asthma: causes, effects and research implications. Journal of Psychosomatic Research, 44, 43–52.

Chowienczyk, P. J., Parkin, D. H., Lawson, C. P., et al. (1994). Do asthmatic patients correctly record home spirometry measurements? BMJ, 309, 1618.

Clarke, P. S., & Gibson, J. R. (1980). Asthma hyperventilation and emotion. Aust Fam Physician, 9, 715–9.

Cooper, S., Oborne, J., Newton, S., et al. (2003). Effects of two breathing exercises (buteyko and pranayama) in asthma: A randomized controlled trial. Thorax, 58, 674–679.

Davis, M. S., & Freed, A. N. (2001). Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs. American Journal of Respiratory and Critical Care Medicine, 164, 785–789.

Davis, M. S., Schofield, B., & Freed, A. N. (2003). Repeated peripheral airway hyperpnea causes inflammation and remodeling in dogs. Medicine and Science in Sports and Exercise, 35, 608–616.

Douma, W. R., Kerstjens, H. A., Roos, C. M., et al. (2000). Changes in peak expiratory flow indices as a proxy for changes in bronchial hyperresponsiveness. Dutch Chronic Non-Specific Lung Disease study group. European Respiratory Journal, 16, 220–225.

Ernst, E. (2000). Breathing techniques—adjunctive treatment modalities for asthma? A systematic review. European Respiratory Journal, 15, 969–972.

Fish, J. E., Ankin, M. G., Kelly, J. F., et al. (1981). Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects. Journal of Applied Physiology, 50, 1079–1086.

Folgering H. T. M., Lenders J., & Rosier I. (1980). Biofeedback control of Paco2, a prospective therapy in hyperventilation. Progress in respiratory research, vol. 14, Asthma. In: H. Herzog et al. (Eds.), Karger, Basel, pp.26–30.

Fujimori, K., Satoh, M., & Arakawa, M. (1996). Ventilatory response to continuous incremental changes in respiratory resistance in patients with mild asthma. Chest, 109, 1525–1531.

Giardino, N. D., Chan, L., & Borson, S. (2004). Combined heart rate variability and pulse oximetry biofeedback for chronic obstructive pulmonary disease: preliminary findings. Applied Psychophysiology and Biofeedback 29, 121–133.

Hasler, G., Gergen, P. J., Kleinbaum, D. G., Ajdacic, V., et al. (2005). Asthma and panic in young adults. A twenty year prospective community study. American Journal of Respiratory and Critical Care Medicine, 171, 1224–30.

Herxheimer, H. (1946). Hyperventilation asthma. Lancet, 1, 83–87.

Holloway, E., & Ram, F. S. (2004). Breathing exercises for asthma. Cochrane Database Syst Rev (1):CD001277.

Hormbrey, J., Jacobi, M. S., Patil, C. P., & Saunders, K. B. (1988). CO2 response and pattern of breathing in patients with symptomatic hyperventilation, compared to asthmatic and normal subjects. European Respiratory Journal, 1, 846–851.

Hyland, M. E., Kenyon, C. A. P., Taylor, M., et al. (1993). Steroid prescribing for asthmatics: Relationship with Asthma Symptom Checklist and Living with Asthma Questionnaire. British Journal of Clinical Psychology, 32, 505–511.

Joseph, C. N., Porta, C., Casucci, G., Casiraghi, N., Maffeis, M., Rossi, M., & Bernardi, L. (2005). Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. Hypertension, 46, 714–718.

Juniper, E. F., O’Byrne, P. M., Guyatt, G. H., et al. (1999). Development and validation of a questionnaire to measure asthma control. European Respiratory Journal, 14, 902–907.

Kelsen, S. G., Fleegler, B., & Altose, M. D. (1979). The respiratory neuromuscular response to hypoxia, hypercapnia, and obstruction to airflow in asthma. American Review of Respiratory Disease, 120, 517–527.

Kinsman, R. A., Spector, S., Shucard, D. W., et al. (1974). Observations on patterns of subjective symptomatology of acute asthma. Psychosomatic Medicine, 36, 129–143.

Lehrer, P. M., Vaschillo, E., Vaschillo, B., et al. (2004). Biofeedback treatment for asthma. Chest, 126, 352–61.

Lutchen, K. R., Jensen, A., Atileh, H., et al. (2001). Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. American Journal of Respiratory and Critical Care Medicine, 164, 207–215.

McFadden, E. R. Jr, & Gilbert, I. A. (1994). Exercise-induced asthma. New England Journal of Medicine, 330, 1362–1367.

McFadden, E. R. Jr, & Lyons, H. A. (1968). Arterial-blood gas tension in asthma. New England Journal of Medicine, 278, 1027–1032.

McHugh, P., Aitcheson, F., & Duncan, B., et al. (2003). Buteyko Breathing Technique for asthma: an effective intervention. New Zealand Medical Journal, 116, U710.

Meuret, A. E., Wilhelm, F. H., Ritz, T. et al. Feedback of end-tidal pCO 2 as a therapeutic approach for panic disorder. Submitted.

Meuret, A. E., Wilhelm, F. H., & Roth, W. T. (2001). Respiratory biofeedback-assisted therapy in panic disorder. Behavior Modification, 25, 584–605.

Meuret, A. E., Wilhelm, F. H., & Roth, W. T. (2004). Respiratory feedback for treating panic disorder. Journal of Clinical Psychology, 60, 197–207.

Milgrom, H., Wamboldt, F., & Bender, B. (2002). Monitoring adherence to the therapy of asthma. Current Opinion in Allergy and Clinical Immunology, 2, 201–205.

National Heart Lung and Blood Institute. Expert panel report: Guidelines for the diagnosis and management of asthma. Update on selected topics 2002. NIH publication #02–5074. National Institutes of Health, Bethesda, MD 2003.

Newhouse, M. T., Becklake, M. R., Macklem, P. T., et al. (1964). Effect of alterations in end-tidal CO2 tension on flow resistance. Journal of Applied Physiology, 19, 745–749.

Opat, A. J., Cohen, M. M., & Bailey, M. J., et al. (2000). A clinical trial of the buteyko breathing technique in asthma as taught by video. Journal of Asthma, 37, 557–564.

Osborne, C. A., O’Connor, B. J., Lewis, A., et al. (2000). Hyperventilation and asymptomatic chronic asthma. Thorax, 55, 1016–1022.

Reddel, H., Jenkins, C., & Woolcock, A. (1999). Diurnal variability-time to change asthma guidelines? BMJ, 319, 45–7.

Reddel, H. K., Salome, C. M., Peat, J. K., et al. (1995). Which index of peak expiratory flow is most useful in the management of stable asthma? American Journal of Respiratory and Critical Care Medicine, 151, 1320–1325.

Ritz, T., Bobb, C., Edwards, M., et al. (2001). The structure of symptom report in asthma. A re-evaluation. Journal of Psychosomatic Research, 51, 639–645.

Ritz, T., Dahme, B., DuBois, A. B., et al. (2002). Guidelines for mechanical lung function measurements in psychophysiology. Psychophysiology, 39, 546–567.

Ritz, T., Dahme, B., & Wagner, C. (1998). Effects of static forehead and forearm muscle tension on total respiratory resistance in healthy and asthmatic participants. Psychophysiology, 35, 549–562.

Ritz, T., Meuret, A. E., Wilhelm, F., & Roth, W. T. (2003). End-tidal PCO2 levels in asthma patients in the laboratory and at home. Biological Psychology, 2, 233–234 (abstract).

Ritz, T., & Roth, W. T. (2003). Behavioral interventions in asthma: Breathing training. Behavior Modification, 27, 710–730.

Ritz, T., & Steptoe, A. (2000). Emotion and pulmonary function in asthma: Reactivity in the field and relationship with laboratory induction of emotion. Psychosomatic Medicine, 62, 808–815.

Ritz, T., Thöns, M., Fahrenkrug, S., et al. (2005). Airways, respiration, and respiratory sinus arrhythmia during picture viewing. Psychophysiology, 42, 568–78.

Schein, M. H., Gavish, B., Herz, M., et al. (2001). Treating hypertension with a device that slows and regularises breathing: a randomised, double-blind controlled study. Journal of Human Hypertension, 15, 271–278.

Stalmatski, A. (1997). Freedom from asthma. Buteyko’s revolutionary treatment. London: Kyle Cathie.

Steen, N., Hutchinson, A., McColl, E., et al. (1994). Development of a symptom based outcome measure for asthma. BMJ 309, 1065–1068.

Sterling, G. M. (1968). The mechanism of bronchoconstriction due to hypocapnia in man. Clinical Science, 34, 277–285.

Thomas, M., McKinley, R. K., Freeman, E., et al. (2003). Breathing retraining for dysfunctional breathing in asthma: a randomized controlled trial. Thorax, 58, 110–5.

van den Elshout, F. J. J., van Herwaarden, C. L. A., & Folgering, H. T. M. (1991). Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects. Thorax, 46, 28–32.

van Doorn, P., Folgering, H. T. M., & Colla, P. (1982). Control of the end-tidal pCO2 in the hyperventilation syndrome: effects of biofeedback and breathing instructions compared. Bulletin of European Physiopathol and Respiration, 18, 829–36.

Varray, A., & Prefaut, C. (1992). Importance of physical exercise training in asthmatics. Journal of Asthma 29, 229–234.

Wagner, P. D., Hedenstierna, G., & Rodriguez-Roisin, R. (1996). Gas exchange, expiratory flow obstruction and the clinical spectrum of asthma. European Respiratory Journal, 9, 1278–1282.

Walters, E. H., & Johns, D. P. (2001). Unravelling the Buteyko effect. Medical Journal of Australia, 174, 64–65.

Ware, J. E., Kosinski, M., & Keller, S. D. (1996). A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity. Medical Care, 34, 220–233.

Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of Personality and Social Psychology, 54, 1063–1070.

Wilhelm, F. H., Alpers, G. W., Meuret, A. E., et al. (2001a). Respiratory pathophysiology of clinical anxiety outside the laboratory: Assessment of end-tidal pCO2, respiratory pattern variability, and transfer function RSA. In: J. Fahrenberg (Ed.), Progress in ambulatory assessment (pp. 313–343). Göttingen: Hogrefe & Huber.

Wilhelm, F. H., Gerlach, A. L., & Roth, W. T. (2001b). Slow recovery from voluntary hyperventilation in panic disorder. Psychosomatic Medicine, 63, 638–649.

Wright, R. J. (2004). Alternative modalities for asthma that reduce stress and modify mood states: evidence for underlying psychobiologic mechanisms. Annals of Allergy Asthma & Immunology, 93(2 Suppl 1), S18–23.