Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

Ryter, 2009, Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy, Am J Respir Cell Mol Biol, 41, 251, 10.1165/rcmb.2009-0170TR

Tenhunen, 1968, The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase, Proc Natl Acad Sci U S A, 61, 748, 10.1073/pnas.61.2.748

Tenhunen, 1969, Microsomal heme oxygenase. Characterization of the enzyme, J Biol Chem, 244, 6388, 10.1016/S0021-9258(18)63477-5

Maines, 1988, Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications, FASEB J, 2, 2557, 10.1096/fasebj.2.10.3290025

Alam, 1989, Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells, J Biol Chem, 264, 6371, 10.1016/S0021-9258(18)83358-0

Keyse, 1989, Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite, Proc Natl Acad Sci U S A, 86, 99, 10.1073/pnas.86.1.99

Keyse, 1987, Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts, J Biol Chem, 262, 14821, 10.1016/S0021-9258(18)47869-6

Saunders, 1991, Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells, Arch Biochem Biophys, 288, 368, 10.1016/0003-9861(91)90208-Z

Hartsfield, 1997, Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide, Am J Phys, 273, L980

Camhi, 1998, Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: role of reactive oxygen intermediates and AP-1, Am J Respir Cell Mol Biol, 18, 226, 10.1165/ajrcmb.18.2.2910

Chen, 2005, Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells, Biochem Biophys Res Commun, 331, 993, 10.1016/j.bbrc.2005.03.237

Motterlini, 2000, Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress, Free Radic Biol Med, 28, 1303, 10.1016/S0891-5849(00)00294-X

Balogun, 2003, Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element, Biochem J, 371, 887, 10.1042/bj20021619

Scapagnini, 2002, Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers, Mol Pharmacol, 61, 554, 10.1124/mol.61.3.554

Lin, 2004, Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells, Pharmacology, 71, 107, 10.1159/000076947

Yao, 2007, Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways, J Hepatol, 47, 253, 10.1016/j.jhep.2007.02.008

Rayamajhi, 2013, Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 cells, Oxid Med Cell Longev, 2013, 154279, 10.1155/2013/154279

Pullikotil, 2012, Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α, J Nutr Biochem, 23, 1134, 10.1016/j.jnutbio.2011.06.007

Andreadi, 2006, Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols, Mol Pharmacol, 69, 1033, 10.1124/mol.105.018374

Shibahara, 1987, Transcriptional control of rat heme oxygenase by heat shock, J Biol Chem, 262, 12889, 10.1016/S0021-9258(18)45138-1

Lee, 1997, Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia, J Biol Chem, 272, 5375, 10.1074/jbc.272.9.5375

Lee, 1996, Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury, Am J Respir Cell Mol Biol, 14, 556, 10.1165/ajrcmb.14.6.8652184

Zhang, 2002, Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury, Am J Physiol Lung Cell Mol Physiol, 283, L815, 10.1152/ajplung.00485.2001

Ryter, 2010, Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine, Curr Drug Targets, 11, 1485, 10.2174/1389450111009011485

Yachie, 1999, Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency, J Clin Invest, 103, 129, 10.1172/JCI4165

Poss, 1997, Heme oxygenase 1 is required for mammalian iron reutilization, Proc Natl Acad Sci U S A, 94, 10919, 10.1073/pnas.94.20.10919

Poss, 1997, Reduced stress defense in heme oxygenase 1-deficient cells, Proc Natl Acad Sci U S A, 94, 10925, 10.1073/pnas.94.20.10925

Ryter, 2006, Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications, Physiol Rev, 86, 583, 10.1152/physrev.00011.2005

Duckers, 2001, Heme oxygenase-1 protects against vascular constriction and proliferation, Nat Med, 7, 693, 10.1038/89068

Fujita, 2001, Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis, Nat Med, 7, 598, 10.1038/87929

Yet, 1999, Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice, J Clin Invest, 103, R23, 10.1172/JCI6163

Yet, 2001, Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice, Circ Res, 89, 168, 10.1161/hh1401.093314

Vulapalli, 2002, Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis, Am J Physiol Heart Circ Physiol, 283, H688, 10.1152/ajpheart.00133.2002

Hull, 2013, Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase, Lab Invest, 93, 868, 10.1038/labinvest.2013.74

Minamino, 2001, Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia, Proc Natl Acad Sci U S A, 98, 8798, 10.1073/pnas.161272598

Zampetaki, 2003, Effect of heme oxygenase-1 overexpression in two models of lung inflammation, Exp Biol Med (Maywood), 228, 442, 10.1177/15353702-0322805-02

Grochot-Przeczek, 2009, Heme oxygenase-1 accelerates cutaneous wound healing in mice, PLoS One, 4, e5803, 10.1371/journal.pone.0005803

Song, 2012, Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment, J Neurochem, 123, 325, 10.1111/j.1471-4159.2012.07914.x

Zukor, 2009, HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues, J Neurochem, 109, 776, 10.1111/j.1471-4159.2009.06007.x

Song, 2006, Over-expression of hemeoxygenase-1 promotes oxidative mitochondrial damage in rat astroglia, J Cell Physiol, 206, 655, 10.1002/jcp.20509

Suttner, 1999, Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron, FASEB J, 13, 1800, 10.1096/fasebj.13.13.1800

Kvam, 2000, Heme oxygenase activity causes transient hypersensitivity to oxidative ultraviolet A radiation that depends on release of iron from heme, Free Radic Biol Med, 28, 1191, 10.1016/S0891-5849(00)00205-7

Ryter, 2000, The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties, Free Radic Biol Med, 28, 289, 10.1016/S0891-5849(99)00223-3

Motterlini, 2010, The therapeutic potential of carbon monoxide, Nat Rev Drug Discov, 9, 728, 10.1038/nrd3228

Otterbein, 2000, Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway, Nat Med, 6, 422, 10.1038/74680

Mazzola, 2005, Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs, FASEB J, 19, 2045, 10.1096/fj.05-3782fje

Mitchell, 2010, Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation, Am J Physiol Lung Cell Mol Physiol, 299, L891, 10.1152/ajplung.00366.2009

Otterbein, 1999, Carbon monoxide provides protection against hyperoxic lung injury, Am J Phys, 276, L688

Otterbein, 2003, MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury, Am J Pathol, 163, 2555, 10.1016/S0002-9440(10)63610-3

Dolinay, 2004, Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury, Am J Respir Crit Care Med, 170, 613, 10.1164/rccm.200401-023OC

Hoetzel, 2009, Carbon monoxide prevents ventilator-induced lung injury via caveolin-1, Crit Care Med, 37, 1708, 10.1097/CCM.0b013e31819efa31

Hoetzel, 2008, Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1, Am J Respir Crit Care Med, 177, 1223, 10.1164/rccm.200708-1265OC

Lee, 2014, Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis, Antioxid Redox Signal, 20, 432, 10.1089/ars.2013.5368

Tsoyi, 2009, Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo, Mol Pharmacol, 76, 173, 10.1124/mol.109.055137

Dalli, 2015, Proresolving lipid mediator profiles in baboon pneumonia are regulated by inhaled carbon monoxide, Am J Respir Cell Mol Biol, 10.1165/rcmb.2014-0299OC

Zhang, 2003, Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3, J Biol Chem, 278, 1248, 10.1074/jbc.M208419200

Amersi, 2002, Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway, Hepatology, 35, 815, 10.1053/jhep.2002.32467

Otterbein, 2003, Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury, Nat Med, 9, 183, 10.1038/nm817

Belcher, 2006, Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice, J Clin Invest, 116, 808, 10.1172/JCI26857

Beckman, 2009, Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease, Am J Physiol Heart Circ Physiol, 297, H1243, 10.1152/ajpheart.00327.2009

Song, 2003, Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects, Am J Pathol, 163, 231, 10.1016/S0002-9440(10)63646-2

Kohmoto, 2006, Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts, Surgery, 140, 179, 10.1016/j.surg.2006.03.004

Zhou, 2011, Protection against lung graft injury from brain-dead donors with carbon monoxide, biliverdin, or both, J Heart Lung Transplant, 30, 460, 10.1016/j.healun.2010.11.020

Sahara, 2010, Beneficial effects of perioperative low-dose inhaled carbon monoxide on pulmonary allograft survival in MHC-inbred CLAWN miniature swine, Transplantation, 90, 1336, 10.1097/TP.0b013e3181ff8730

Nakao, 2011, Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts, Cardiovasc Res, 89, 457, 10.1093/cvr/cvq298

Sato, 2001, Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants, J Immunol, 166, 4185, 10.4049/jimmunol.166.6.4185

Nakao, 2005, Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both, Am J Transplant, 5, 282, 10.1111/j.1600-6143.2004.00695.x

Nakao, 2006, Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses, Transplantation, 81, 220, 10.1097/01.tp.0000188637.80695.7f

Akamatsu, 2004, Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury, FASEB J, 18, 771, 10.1096/fj.03-0921fje

Nakao, 2010, Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both, J Heart Lung Transplant, 29, 544, 10.1016/j.healun.2009.10.011

Ozaki, 2012, Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death, Transpl Int, 25, 107, 10.1111/j.1432-2277.2011.01363.x

Nakao, 2009, Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restoresrenal allograft function, Am J Physiol Renal Physiol, 297, F19, 10.1152/ajprenal.90728.2008

Faleo, 2008, Carbon monoxide ameliorates renal cold ischemia-reperfusion injury with an upregulation of vascular endothelial growth factor by activation of hypoxia-inducible factor, Transplantation, 85, 1833, 10.1097/TP.0b013e31817c6f63

Neto, 2004, Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide, Am J Physiol Renal Physiol, 287, F979, 10.1152/ajprenal.00158.2004

Hanto, 2010, Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine, Am J Transplant, 10, 2421, 10.1111/j.1600-6143.2010.03289.x

Yoshida, 2010, Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs, Am J Transplant, 10, 763, 10.1111/j.1600-6143.2010.03040.x

Kaizu, 2005, Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantation, Surgery, 138, 229, 10.1016/j.surg.2005.06.015

Ikeda, 2009, Liver graft exposure to carbon monoxide during cold storage protects sinusoidal endothelial cells and ameliorates reperfusion injury in rats, Liver Transpl, 15, 1458, 10.1002/lt.21918

Nakao, 2003, Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts, Surgery, 134, 285, 10.1067/msy.2003.238

Nakao, 2006, Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury, Am J Transplant, 6, 2243, 10.1111/j.1600-6143.2006.01465.x

Lee, 2007, Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells, FASEB J, 21, 3450, 10.1096/fj.07-8472com

Wang, 2005, Donor treatment with carbon monoxide can yield islet allograft survival and tolerance, Diabetes, 54, 1400, 10.2337/diabetes.54.5.1400

Günther, 2002, Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation, Diabetes, 51, 994, 10.2337/diabetes.51.4.994

Fondevila, 2004, Biliverdin therapy protects rat livers from ischemia and reperfusion injury, Hepatology, 40, 1333, 10.1002/hep.20480

Adin, 2005, Protective effects of exogenous bilirubin on ischemia–reperfusion injury in the isolated, perfused rat kidney, Am J Physiol Renal Physiol, 288, F778, 10.1152/ajprenal.00215.2004

Yamashita, 2004, Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts, FASEB J, 18, 765, 10.1096/fj.03-0839fje

Morse, 2009, Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease, Free Radic Biol Med, 47, 1, 10.1016/j.freeradbiomed.2009.04.007

Simon, 2011, Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer, Immunotherapy, 3, 15, 10.2217/imt.11.43

Motterlini, 2014, Heme oxygenase-1 as a target for drug discovery, Antioxid Redox Signal, 20, 1810, 10.1089/ars.2013.5658

Yoshida, 1982, The step of carbon monoxide liberation in the sequence of heme degradation catalyzed by the reconstituted microsomal heme oxygenase system, J Biol Chem, 257, 9345, 10.1016/S0021-9258(18)34075-4

Noguchi, 1982, Identification of the product of heme degradation catalyzed by the heme oxygenase system as biliverdin IX alpha by reversed-phase high-performance liquid chromatography, J Biochem, 91, 1479, 10.1093/oxfordjournals.jbchem.a133839

Kikuchi, 2005, Heme oxygenase and heme degradation, Biochem Biophys Res Commun, 338, 558, 10.1016/j.bbrc.2005.08.020

Matsui, 2010, Heme oxygenase reveals its strategy for catalyzing three successive oxygenation reactions, Acc Chem Res, 43, 240, 10.1021/ar9001685

Matsui, 2010, Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase, Inorg Chem, 49, 3602, 10.1021/ic901869t

Noguchi, 1979, Specific requirement of NADPH-cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IX alpha, FEBS Lett, 98, 281, 10.1016/0014-5793(79)80200-8

Sugishima, 2014, Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase, Proc Natl Acad Sci U S A, 111, 2524, 10.1073/pnas.1322034111

Higashimoto, 2005, Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase, J Biol Chem, 280, 729, 10.1074/jbc.M406203200

Yoshida, 1980, Oxygenated form of heme. heme oxygenase complex and requirement for second electron to initiate heme degradation from the oxygenated complex, J Biol Chem, 255, 4418, 10.1016/S0021-9258(19)85506-0

Yoshida, 2000, Mechanism of heme degradation by heme oxygenase, J Inorg Biochem, 82, 33, 10.1016/S0162-0134(00)00156-2

Yoshida, 1981, Degradation of mesoheme and hydroxymesoheme catalyzed by the heme oxygenase system: involvement of hydroxyheme in the sequence of heme catabolism, J Biochem, 90, 125, 10.1093/oxfordjournals.jbchem.a133441

Higashimoto, 2006, The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN, J Biol Chem, 281, 31659, 10.1074/jbc.M606163200

Matera, 1996, Oxygen and one reducing equivalent are both required for the conversion of alpha-hydroxyhemin to verdoheme in heme oxygenase, J Biol Chem, 271, 6618, 10.1074/jbc.271.12.6618

Gohya, 2008, Variation of the oxidation state of verdoheme in the heme oxygenase reaction, Biochem Biophys Res Commun, 376, 293, 10.1016/j.bbrc.2008.08.141

Tenhunen, 1970, Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization, Biochemistry, 9, 298, 10.1021/bi00804a016

Maines, 1986, Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible, J Biol Chem, 261, 411, 10.1016/S0021-9258(17)42488-4

Trakshel, 1986, Purification and characterization of the major constitutive form of testicular heme oxygenase, J Biol Chem, 261, 11131, 10.1016/S0021-9258(18)67358-2

Maines, 1997, The heme oxygenase system: a regulator of second messenger gases, Annu Rev Pharmacol Toxicol, 37, 517, 10.1146/annurev.pharmtox.37.1.517

Cruse, 1998, Evidence suggesting that the two forms of heme oxygenase are products of different genes, J Biol Chem, 263, 3348, 10.1016/S0021-9258(18)69078-7

Rotenberg, 1990, Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2, J Biol Chem, 265, 7501, 10.1016/S0021-9258(19)39141-0

Rotenberg, 1991, Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: possible heme-binding site?, Arch Biochem Biophys, 290, 336, 10.1016/0003-9861(91)90549-X

Ishikawa, 1991, Expression of rat heme oxygenase in Escherichia coli as a catalytically active, full length form that binds to bacterial membranes, Eur J Biochem, 202, 161, 10.1111/j.1432-1033.1991.tb16357.x

McCoubrey, 1997, Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis, J Biol Chem, 272, 12568, 10.1074/jbc.272.19.12568

Converso, 2006, HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism, FASEB J, 20, 1236, 10.1096/fj.05-4204fje

Slebos, 2007, Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death, Am J Respir Cell Mol Biol, 36, 409, 10.1165/rcmb.2006-0214OC

Kim, 2004, Caveolae compartmentalization of heme oxygenase-1 in endothelial cells, FASEB J, 18, 1080, 10.1096/fj.03-1391com

Taira, 2011, Caveolin-1 is a competitive inhibitor of heme oxygenase-1 (HO-1) with heme: identification of a minimum sequence in caveolin-1 for binding to HO-1, Biochemistry, 50, 6824, 10.1021/bi200601t

Schacter, 1972, Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system, J Biol Chem, 247, 3601, 10.1016/S0021-9258(19)45183-1

Dennery, 2014, Signaling function of heme oxygenase proteins, Antioxid Redox Signal, 20, 1743, 10.1089/ars.2013.5674

Alam, 1994, Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5′ sequences are required for induction by heme or heavy metals, J Biol Chem, 269, 1001, 10.1016/S0021-9258(17)42211-3

Alam, 1995, Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer, J Biol Chem, 270, 11977, 10.1074/jbc.270.20.11977

Alam, 1992, Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene, J Biol Chem, 267, 21894, 10.1016/S0021-9258(19)36696-7

Alam, 1999, Nrf2, a Cap‘n’Collar transcription factor, regulates induction of the heme oxygenase-1 gene, J Biol Chem, 274, 26071, 10.1074/jbc.274.37.26071

Itoh, 2003, Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles, Genes Cells, 8, 379, 10.1046/j.1365-2443.2003.00640.x

Itoh, 1999, Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain, Genes Dev, 13, 76, 10.1101/gad.13.1.76

Kobayashi, 2002, Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system, Genes Cells, 7, 807, 10.1046/j.1365-2443.2002.00561.x

Dinkova-Kostova, 2002, Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants, Proc Natl Acad Sci U S A, 99, 11908, 10.1073/pnas.172398899

Komatsu, 2010, The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1, Nat Cell Biol, 12, 213, 10.1038/ncb2021

Taguchi, 2012, Keap1 degradation by autophagy for the maintenance of redox homeostasis, Proc Natl Acad Sci U S A, 109, 13561, 10.1073/pnas.1121572109

Sun, 2002, Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene, EMBO J, 21, 5216, 10.1093/emboj/cdf516

Sun, 2004, Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network, Proc Natl Acad Sci U S A, 101, 1461, 10.1073/pnas.0308083100

Miyazaki, 2010, Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1, Cancer Sci, 101, 1409, 10.1111/j.1349-7006.2010.01550.x

Dorresteijn, 2015, Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells, Free Radic Biol Med, 78, 224, 10.1016/j.freeradbiomed.2014.10.579

Takeda, 1994, Identification of a cis-acting element that is responsible for cadmium-mediated induction of the human heme oxygenase gene, J Biol Chem, 269, 22858, 10.1016/S0021-9258(17)31724-6

Yang, 2001, Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis, Blood, 97, 1306, 10.1182/blood.V97.5.1306

Sikorski, 2004, The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury, Am J Physiol Renal Physiol, 286, F425, 10.1152/ajprenal.00297.2003

Alam, 2004, Regulation of heme oxygenase-1 gene transcription: recent advances and highlights from the International Conference (Uppsala, 2003) on Heme Oxygenase, Antioxid Redox Signal, 6, 924, 10.1089/ars.2004.6.924

Alam, 2007, How many transcription factors does it take to turn on the heme oxygenase-1 gene?, Am J Respir Cell Mol Biol, 36, 166, 10.1165/rcmb.2006-0340TR

Exner, 2004, The role of heme oxygenase-1 promoter polymorphisms in human disease, Free Radic Biol Med, 37, 1097, 10.1016/j.freeradbiomed.2004.07.008

Bao, 2010, Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis, Am J Epidemiol, 172, 631, 10.1093/aje/kwq162

Pechlaner, 2015, Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease, Arterioscler Thromb Vasc Biol, 35, 229, 10.1161/ATVBAHA.114.304729

Chen, 2014, Length polymorphism in heme oxygenase-1 and risk of CKD among patients with coronary artery disease, J Am Soc Nephrol, 25, 2669, 10.1681/ASN.2013111205

Gulla, 2014, Heme oxygenase-1 gene promoter polymorphism is associated with the development of necrotizing acute pancreatitis, Pancreas, 43, 1271, 10.1097/MPA.0000000000000171

Kaartokallio, 2014, Microsatellite polymorphism in the heme oxygenase-1 promoter is associated with nonsevere and late-onset preeclampsia, Hypertension, 64, 172, 10.1161/HYPERTENSIONAHA.114.03337

Yamada, 2000, Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema, Am J Hum Genet, 66, 187, 10.1086/302729

Sheu, 2009, Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome, Intensive Care Med, 35, 1343, 10.1007/s00134-009-1504-6

Exner, 2001, Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty, J Endovasc Ther, 8, 433, 10.1177/152660280100800501

Chen, 2004, Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting, Eur Heart J, 25, 39, 10.1016/j.ehj.2003.10.009

Schillinger, 2004, Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor, J Am Coll Cardiol, 43, 950, 10.1016/j.jacc.2003.09.058

Rueda, 2007, HO-1 promoter polymorphism associated with rheumatoid arthritis, Arthritis Rheum, 56, 3953, 10.1002/art.23048

Exner, 2004, Donor heme oxygenase-1 genotype is associated with renal allograft function, Transplantation, 77, 538, 10.1097/01.TP.0000113467.36269.F8

Tiwari, 2013, Heme oxygenase-1 gene variants and hyperbilirubinemia risk in North Indian newborns, Eur J Pediatr, 172, 1627, 10.1007/s00431-013-2091-7

Kramer, 2013, Alternative 5′ untranslated regions are involved in expression regulation of human heme oxygenase-1, PLoS One, 8, e77224, 10.1371/journal.pone.0077224

Cao, 2014, Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke, J Neurol Sci, 344, 154, 10.1016/j.jns.2014.06.046

Ayuso, 2014, An association study between heme oxygenase-1 genetic variants and Parkinson's disease, Front Cell Neurosci, 8, 298, 10.3389/fncel.2014.00298

Ullrich, 2005, Microsatellite polymorphism in the heme oxygenase-1 gene promoter and cardiac allograft vasculopathy, J Heart Lung Transplant, 24, 1600, 10.1016/j.healun.2004.11.009

Courtney, 2007, Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes, Am J Transplant, 7, 908, 10.1111/j.1600-6143.2006.01726.x

Han, 2014, HMOX1 gene promoter polymorphism is not associated with coronary artery disease in Koreans, Ann Lab Med, 34, 337, 10.3343/alm.2014.34.5.337

Lemaire, 2014, Microsatellite polymorphism in the heme oxygenase-1 gene promoter is not associated with alcoholic liver disease severity, Hepatology, 59, 352, 10.1002/hep.26534

Tanaka, 2011, Effect of heme oxygenase-1 polymorphisms on lung function and gene expression, BMC Med Genet, 12, 117, 10.1186/1471-2350-12-117

Cheng, 2013, Regulation of the Nrf2 antioxidant pathway by microRNAs: new players in micromanaging redox homeostasis, Free Radic Biol Med, 64, 4, 10.1016/j.freeradbiomed.2013.07.025

Narasimhan, 2012, Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells, PLoS One, 7, e51111, 10.1371/journal.pone.0051111

Stachurska, 2013, Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells, Mol Nutr Food Res, 57, 504, 10.1002/mnfr.201200456

Do, 2014, Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents, Free Radic Biol Med, 74, 21, 10.1016/j.freeradbiomed.2014.06.010

Xiao, 2015, MiR-24-3p promotes porcine reproductive and respiratory syndrome virus replication through suppression of heme oxygenase-1 expression, J Virol, 89, 4494, 10.1128/JVI.02810-14

Lorenzen, 2014, MicroRNA-24 antagonism prevents renal ischemia reperfusion injury, J Am Soc Nephrol, 25, 2717, 10.1681/ASN.2013121329

Fiedler, 2014, Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization, Antioxid Redox Signal, 21, 1167, 10.1089/ars.2013.5418

Li, 2014, MiR-204/miR-211 downregulation contributes to candidemia-induced kidney injuries via derepression of Hmx1 expression, Life Sci, 102, 139, 10.1016/j.lfs.2014.03.010

Zhang, 2015, Micro-RNA-155-mediated control of heme oxygenase 1 (HO-1) is required for restoring adaptively tolerant CD4(+) T-cell function in rodents, Eur J Immunol, 45, 829, 10.1002/eji.201445066

Skrzypek, 2013, Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis, Antioxid Redox Signal, 19, 644, 10.1089/ars.2013.5184

Beckman, 2011, Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217, J Biol Chem, 286, 3194, 10.1074/jbc.M110.148726

Pulkkinen, 2011, Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells, Free Radic Biol Med, 51, 2124, 10.1016/j.freeradbiomed.2011.09.014

Hou, 2010, MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins, Hepatology, 51, 1494, 10.1002/hep.23401

Hou, 2012, The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes, Biochim Biophys Acta, 1819, 1113, 10.1016/j.bbagrm.2012.06.001

Kim, 2014, Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3, Antioxid Redox Signal, 21, 2469, 10.1089/ars.2014.5856

Eades, 2011, miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells, J Biol Chem, 286, 40725, 10.1074/jbc.M111.275495

Kozakowska, 2014, Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs, Antioxid Redox Signal, 20, 1827, 10.1089/ars.2013.5341

Kozakowska, 2012, Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs, Antioxid Redox Signal, 16, 113, 10.1089/ars.2011.3964

Willis, 1996, Heme oxygenase: a novel target for the modulation of the inflammatory response, Nat Med, 2, 87, 10.1038/nm0196-87

Inoue, 2001, Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice, Hum Gene Ther, 12, 967, 10.1089/104303401750195926

Morse, 2003, Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1, J Biol Chem, 278, 36993, 10.1074/jbc.M302942200

Kim, 2005, Heat shock factor-1 mediates the cytoprotective effect of carbon monoxide, J Immunol, 175, 2622, 10.4049/jimmunol.175.4.2622

Sarady, 2004, Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver, FASEB J, 18, 854, 10.1096/fj.03-0643fje

Sarady-Andrews, 2005, Biliverdin administration protects against endotoxin-induced acute lung injury in rats, Am J Physiol Lung Cell Mol Physiol, 289, L1131, 10.1152/ajplung.00458.2004

Lee, 2002, Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice, Nat Med, 8, 240, 10.1038/nm0302-240

Nakahira, 2006, Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts, J Exp Med, 203, 2377, 10.1084/jem.20060845

Jamal Uddin, 2015, IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production, Cell Mol Immunol

Schroder, 2010, The inflammasomes, Cell, 140, 821, 10.1016/j.cell.2010.01.040

Davis, 2011, The inflammasome NLRs in immunity, inflammation, and associated diseases, Annu Rev Immunol, 29, 707, 10.1146/annurev-immunol-031210-101405

Luo, 2014, Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1, Int Immunopharmacol, 20, 24, 10.1016/j.intimp.2014.02.017

Kim, 2013, NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1, Free Radic Biol Med, 65, 997, 10.1016/j.freeradbiomed.2013.08.178

Jung, 2015, Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages, Am J Physiol Lung Cell Mol Physiol, 308, L1058, 10.1152/ajplung.00400.2014

Kim, 2014, Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways, Innate Immun, 20, 799, 10.1177/1753425913508593

Wegiel, 2014, Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation, J Clin Invest, 124, 4926, 10.1172/JCI72853

Chung, 2008, Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice, J Clin Invest, 118, 239, 10.1172/JCI32730

Larsen, 2010, A central role for free heme in the pathogenesis of severe sepsis, Sci Transl Med, 2, 51ra71, 10.1126/scitranslmed.3001118

Takamiya, 2009, High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice, Am J Respir Cell Mol Biol, 41, 129, 10.1165/rcmb.2008-0331OC

Figueiredo, 2007, Characterization of heme as activator of toll-like receptor 4, J Biol Chem, 282, 20221, 10.1074/jbc.M610737200

Belcher, 2014, Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease, Blood, 123, 377, 10.1182/blood-2013-04-495887

Onyiah, 2013, Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance, Gastroenterology, 144, 789, 10.1053/j.gastro.2012.12.025

Hashiba, 2001, Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice, Gene Ther, 8, 1499, 10.1038/sj.gt.3301540

Belcher, 2010, Heme oxygenase-1 gene delivery by sleeping beauty inhibits vascular stasis in a murine model of sickle cell disease, J Mol Med (Berl), 88, 665, 10.1007/s00109-010-0613-6

Liu, 2006, Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function, FASEB J, 20, 207, 10.1096/fj.05-4435com

Mishra, 2006, Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes, Proc Natl Acad Sci U S A, 13, 5191, 10.1073/pnas.0600241103

Zhang, 2003, Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury, J Biol Chem, 278, 22061, 10.1074/jbc.M301858200

Araujo, 2003, Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse, J Immunol, 171, 1572, 10.4049/jimmunol.171.3.1572

Barbagallo, 2014, The role of the heme oxygenase system in the metabolic syndrome, Curr Pharm Des, 20, 4970, 10.2174/1381612819666131206103824

Hosick, 2012, Heme oxygenase, a novel target for the treatment of hypertension and obesity?, Am J Physiol Regul Integr Comp Physiol, 302, R207, 10.1152/ajpregu.00517.2011

Tu, 2014, Induction of heme oxygenase-1 with hemin reduces obesity-induced adipose tissue inflammation via adipose macrophage phenotype switching, Mediators Inflamm, 2014, 290708, 10.1155/2014/290708

Joe, 2011, The role of carbon monoxide in metabolic disease, Ann N Y Acad Sci, 1229, 156, 10.1111/j.1749-6632.2011.06121.x

Lancel, 2012, Carbon monoxide improves cardiac function and mitochondrial population quality in a mouse model of metabolic syndrome, PLoS One, 7, e41836, 10.1371/journal.pone.0041836

Hosick, 2014, Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet, Int J Obes (Lond), 38, 132, 10.1038/ijo.2013.61

Dong, 2014, Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation, Endocrinology, 155, 818, 10.1210/en.2013-1667

Huang, 2013, Adipose overexpression of heme oxygenase-1 does not protect against high fat diet-induced insulin resistance in mice, PLoS One, 8, e55369, 10.1371/journal.pone.0055369

Jais, 2014, Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man, Cell, 158, 25, 10.1016/j.cell.2014.04.043

Huang, 2012, Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice, PLoS One, 7, e38626, 10.1371/journal.pone.0038626

Naito, 2014, Heme oxygenase-1 and anti-inflammatory M2 macrophages, Arch Biochem Biophys, 564C, 83, 10.1016/j.abb.2014.09.005

Tzima, 2009, Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production, J Exp Med, 206, 1167, 10.1084/jem.20081582

Brusko, 2005, An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells, J Immunol, 174, 5181, 10.4049/jimmunol.174.9.5181

Yamashita, 2006, Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs, FASEB J, 20, 776, 10.1096/fj.05-4791fje

Xia, 2007, Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of Foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor-1, Am J Pathol, 171, 1904, 10.2353/ajpath.2007.070096

Xia, 2006, Heme oxygenase-1-mediated CD4+CD25 high regulatory T cells suppress allergic airway inflammation, J Immunol, 177, 5936, 10.4049/jimmunol.177.9.5936

Choi, 2005, Critical role of heme oxygenase-1min Foxp3-mediated immune suppression, Biochem Biophys Res Commun, 327, 1066, 10.1016/j.bbrc.2004.12.106

Biburger, 2010, Pivotal advance: hemeoxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity, J Leukoc Biol, 87, 193, 10.1189/jlb.0508280

George, 2008, Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells, Am J Pathol, 173, 154, 10.2353/ajpath.2008.070963

Liu, 2015, Heme oxygenase-1 restores impaired GARPCD4(+)CD25(+) regulatory T cells from patients with acute coronary syndrome by upregulating LAP and GARP expression on activated T lymphocytes, Cell Physiol Biochem, 35, 553, 10.1159/000369719

Rémy, 2009, Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity, J Immunol, 182, 1877, 10.4049/jimmunol.0802436

Park, 2010, Heme oxygenase-1 expression in murine dendritic cell subpopulations: effect on CD8+ dendritic cell differentiation in vivo, Am J Pathol, 176, 2831, 10.2353/ajpath.2010.090845

Chauveau, 2005, Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression, Blood, 106, 1694, 10.1182/blood-2005-02-0494

Tardif, 2013, Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells, Eur J Immunol, 43, 2832, 10.1002/eji.201343600

Simon, 2013, Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8+ T cells and protect from type 1 diabetes, Eur J Immunol, 43, 209, 10.1002/eji.201242684

Stevenson, 2010, Metalloporphyrins in the management of neonatal hyperbilirubinemia, Semin Fetal Neonatal Med, 15, 164, 10.1016/j.siny.2009.11.004

Gupta, 2014, Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease, J Neurochem, 131, 778, 10.1111/jnc.12927

Vreman, 1993, Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity, Pediatr Res, 33, 195, 10.1203/00006450-199302000-00021

Wong, 2011, In vitro inhibition of heme oxygenase isoenzymes by metalloporphyrins, J Perinatol, 31, S35, 10.1038/jp.2010.173

He, 2011, Effects of zinc deuteroporphyrin bis glycol on newborn mice after heme loading, Pediatr Res, 70, 467, 10.1203/PDR.0b013e31822e1675

Grundemar, 1997, Pitfalls using metalloporphyrins in carbon monoxide research, Trends Pharmacol Sci, 18, 193, 10.1016/S0165-6147(97)90622-2

Schulz, 2012, Metalloporphyrins—an update, Front Pharmacol, 3, 68, 10.3389/fphar.2012.00068

Rahman, 2012, Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds, J R Soc Interface, 10, 20120697, 10.1098/rsif.2012.0697

Vlahakis, 2006, Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors, J Med Chem, 49, 4437, 10.1021/jm0511435

Vlahakis, 2005, Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors, Bioorg Med Chem Lett, 15, 1457, 10.1016/j.bmcl.2004.12.075

Sugishima, 2007, X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase, Biochemistry, 46, 1860, 10.1021/bi062264p

Kinobe, 2007, Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells, J Pharmacol Exp Ther, 323, 763, 10.1124/jpet.107.119800

Kinobe, 2006, Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms, Br J Pharmacol, 147, 307, 10.1038/sj.bjp.0706555

Kinobe, 2008, Inhibitors of the heme oxygenase—carbon monoxide system: on the doorstep of the clinic?, Can J Physiol Pharmacol, 86, 577, 10.1139/Y08-066

Csongradi, 2010, In vivo inhibition of renal heme oxygenase with an imidazole-dioxolane inhibitor, Pharm Res, 61, 525, 10.1016/j.phrs.2010.02.006

Csongradi, 2012, Renal inhibition of heme oxygenase-1 increases blood pressure in angiotensin II-dependent hypertension, Int J Hypertens, 2012, 497213, 10.1155/2012/497213

Kundu, 2010, Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis, Pharm Res, 27, 999, 10.1007/s11095-010-0096-8

Foresti, 2013, Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells, Pharm Res, 76, 132, 10.1016/j.phrs.2013.07.010

Barbagallo, 2013, Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases, Antioxid Redox Signal, 18, 507, 10.1089/ars.2011.4360

Klickovic, 2014, Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects, Biomed Res Int, 2014, 458592, 10.1155/2014/458592

Dubey, 2015, Dimethyl fumarate in relapsing-remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety, Expert Rev Neurother, 15, 339, 10.1586/14737175.2015.1025755

Nicholas, 2014, Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate, Drug Des Devel Ther, 8, 897

Linker, 2011, Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway, Brain, 134, 678, 10.1093/brain/awq386

Takaya, 2012, Validation of the multiple sensor mechanism of the Keap1-Nrf2 system, Free Radic Biol Med, 53, 817, 10.1016/j.freeradbiomed.2012.06.023

Schilling, 2006, Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration, Clin Exp Immunol, 145, 101, 10.1111/j.1365-2249.2006.03094.x

Oh, 2014, Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms, Redox Biol, 2, 855, 10.1016/j.redox.2014.06.003

Abraham, 2007, Heme oxygenase-1 gene therapy: recent advances and therapeutic applications, Curr Gene Ther, 7, 89, 10.2174/156652307780363134

Otterbein, 1999, Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxic lung injury, J Clin Invest, 103, 1047, 10.1172/JCI5342

Abraham, 1995, Adenovirus-mediated heme oxygenase-1 gene transfer into rabbit ocular tissues, Invest Ophthalmol Vis Sci, 36, 2202

Sabaawy, 2001, Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats, Hypertension, 38, 210, 10.1161/01.HYP.38.2.210

Zhang, 2013, Lung endothelial HO-1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury, FASEB J, 27, 4041, 10.1096/fj.13-231225

Ryter, 2004, Carbon monoxide in biology and medicine, Bioessays, 26, 270, 10.1002/bies.20005

Durante, 2006, Role of carbon monoxide in cardiovascular function, J Cell Mol Med, 10, 672, 10.1111/j.1582-4934.2006.tb00427.x

Suematsu, 1995, Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused ratliver, J Clin Invest, 96, 2431, 10.1172/JCI118300

Suematsu, 1994, Carbon monoxide as an endogenous modulator of hepatic vascular perfusion, Biochem Biophys Res Commun, 205, 1333, 10.1006/bbrc.1994.2811

Kim, 2006, CO as a cellular signaling molecule, Annu Rev Pharmacol Toxicol, 46, 411, 10.1146/annurev.pharmtox.46.120604.141053

Stone, 1994, Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states, Biochemistry, 33, 5636, 10.1021/bi00184a036

Furchgott, 1991, Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light, Blood Vessels, 28, 52

Morita, 1997, Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells, J Biol Chem, 272, 32804, 10.1074/jbc.272.52.32804

Morita, 1995, Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP, Proc Natl Acad Sci U S A, 92, 1475, 10.1073/pnas.92.5.1475

Verma, 1993, Carbon monoxide: a putative neural messenger, Science, 259, 381, 10.1126/science.7678352

Wang, 1998, Resurgence of carbon monoxide: an endogenous gaseous vasorelaxing factor, Can J Physiol Pharmacol, 76, 1, 10.1139/y97-187

Wilkinson, 2011, Carbon monoxide: an emerging regulator of ion channels, J Physiol, 589, 3055, 10.1113/jphysiol.2011.206706

Peers, 2011, Ion channels as target effectors for carbon monoxide, Exp Physiol, 96, 836, 10.1113/expphysiol.2011.059063

Brouard, 2000, Carbon monoxide generated by heme oxygenase-1 suppresses endothelial cell apoptosis, J Exp Med, 192, 1015, 10.1084/jem.192.7.1015

Wang, 2009, The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1, J Immunol, 182, 3809, 10.4049/jimmunol.0712437

Bilban, 2006, Carbon monoxide orchestrates a protective response through PPARgamma, Immunity, 24, 601, 10.1016/j.immuni.2006.03.012

Brouard, 2002, Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis, J Biol Chem, 277, 17950, 10.1074/jbc.M108317200

Zhang, 2005, Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury, J Biol Chem, 280, 8714, 10.1074/jbc.M408092200

Wang, 2007, Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation, J Biol Chem, 282, 1718, 10.1074/jbc.M607610200

Wang, 2011, Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells, Med Gas Res, 1, 8, 10.1186/2045-9912-1-8

Kim, 2005, Caveolin-1 expression by means of p38β mitogen activated protein kinase mediates the antiproliferative effect of carbon monoxide, Proc Natl Acad Sci U S A, 102, 11319, 10.1073/pnas.0501345102

Taille, 2005, Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle, J Biol Chem, 280, 25350, 10.1074/jbc.M503512200

Rodriguez, 2010, HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1, Arterioscler Thromb Vasc Biol, 30, 98, 10.1161/ATVBAHA.109.197822

Meyer, 2015, Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion, Am J Physiol Heart Circ Physiol, 308, H759, 10.1152/ajpheart.00702.2014

Nakao, 2008, Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts, Kidney Int, 74, 1009, 10.1038/ki.2008.342

Zuckerbraun, 2007, Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species, FASEB J, 21, 1099, 10.1096/fj.06-6644com

Chin, 2007, Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning, Proc Natl Acad Sci U S A, 104, 5109, 10.1073/pnas.0609611104

Lee, 2011, Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation, Am J Respir Cell Mol Biol, 45, 867, 10.1165/rcmb.2010-0352OC

Li, 2007, Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling, J Biol Chem, 282, 28577, 10.1074/jbc.M701916200

Piantadosi, 2008, Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1, Circ Res, 103, 1232, 10.1161/01.RES.0000338597.71702.ad

Wang, 2011, Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia, Stroke, 42, 2605, 10.1161/STROKEAHA.110.607101

Motterlini, 2012, Emerging concepts on the anti-inflammatory actions of carbon monoxide-releasing molecules (CO-RMs), Med Gas Res, 2, 2, 10.1186/2045-9912-2-28

Motterlini, 2005, Therapeutic applications of carbon monoxide-releasing molecules (CO-RMs), Expert Opin Investig Drugs, 14, 1305, 10.1517/13543784.14.11.1305

Foresti, 2008, Use of carbon monoxide as a therapeutic agent: promises and challenges, Intensive Care Med, 34, 649, 10.1007/s00134-008-1011-1

Foresti, 2004, Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule, Br J Pharmacol, 142, 453, 10.1038/sj.bjp.0705825

Motterlini, 2005, CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule, FASEB J, 19, 284, 10.1096/fj.04-2169fje

Motterlini, 2013, Vasorelaxing effects and inhibition of nitric oxide in macrophages by new iron-containing carbon monoxide-releasing molecules (CO-RMs), Pharm Res, 68, 108, 10.1016/j.phrs.2012.12.001

Kretschmer, 2011, Dicarbonyl-bis(cysteamine)iron(II): a light induced carbon monoxide releasing molecule based on iron (CORM-S1), J Inorg Biochem, 105, 6, 10.1016/j.jinorgbio.2010.10.006

Nagel, 2014, Introducing [Mn(CO)3(tpa-κ(3)N)](+) as a novel photoactivatable CO-releasing molecule with well-defined iCORM intermediates—synthesis, spectroscopy, and antibacterial activity, Dalton Trans, 43, 9986, 10.1039/c3dt51848e

Pai, 2014, New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe, Dalton Trans, 43, 8664, 10.1039/c4dt00254g

Schatzschneider, 2015, Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs), Br J Pharmacol, 172, 1638, 10.1111/bph.12688

Dördelmann, 2011, Silicium dioxide nanoparticles as carriers for photoactivatable CO-releasing molecules (PhotoCORMs), Inorg Chem, 50, 4362, 10.1021/ic1024197

Wilson, 2014, Design and synthesis of new hybrid molecules that activate the transcription factor Nrf2 and simultaneously release carbon monoxide, Chemistry, 20, 14698, 10.1002/chem.201403901

Sawle, 2005, Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages, Br J Pharmacol, 145, 800, 10.1038/sj.bjp.0706241

Sun, 2008, Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC, Int J Biol Sci, 4, 270, 10.7150/ijbs.4.270

Sun, 2007, Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice, J Surg Res, 139, 128, 10.1016/j.jss.2006.08.032

Cepinskas, 2008, Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice, Am J Physiol Gastrointest Liver Physiol, 294, G184, 10.1152/ajpgi.00348.2007

Mizuguchi, 2009, CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase, Am J Physiol Heart Circ Physiol, 297, H920, 10.1152/ajpheart.00305.2009

Lancel, 2009, Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis, J Pharmacol Exp Ther, 329, 641, 10.1124/jpet.108.148049

Babu, 2015, CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation, Br J Pharmacol, 172, 1557, 10.1111/bph.12632

Wilson, 2013, Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli, Antioxid Redox Signal, 19, 497, 10.1089/ars.2012.4784

Desmard, 2012, Differential antibacterial activity against Pseudomonas aeruginosa by carbon monoxide-releasing molecules, Antioxid Redox Signal, 16, 153, 10.1089/ars.2011.3959

Desmard, 2009, A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia, FASEB J, 23, 1023, 10.1096/fj.08-122804

Rana, 2014, Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometry, Microbiology, 160, 2771, 10.1099/mic.0.081042-0

Chin, 2009, Carbon monoxide is a poison…to microbes! CO as a bactericidal molecule, Curr Opin Pharmacol, 9, 490, 10.1016/j.coph.2009.06.025

Davidge, 2009, Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators, J Biol Chem, 284, 4516, 10.1074/jbc.M808210200

Tavares, 2013, The bactericidal activity of carbon monoxide-releasing molecules against Helicobacter pylori, PLoS One, 8, e83157, 10.1371/journal.pone.0083157

Musameh, 2007, Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3), J Heart Lung Transplant, 26, 1192, 10.1016/j.healun.2007.08.005

Stocker, 2004, Antioxidant activities of bile pigments, Antioxid Redox Signal, 6, 841, 10.1089/ars.2004.6.841

Stocker, 1987, Bilirubin is an antioxidant of possible physiological importance, Science, 235, 1043, 10.1126/science.3029864

Neuzil, 1994, Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation, J Biol Chem, 269, 16712, 10.1016/S0021-9258(19)89449-8

Baranano, 2002, Biliverdin reductase: a major physiologic cytoprotectant, Proc Natl Acad Sci U S A, 99, 16093, 10.1073/pnas.252626999

Wu, 1991, Albumin-bound bilirubins protect human ventricular myocyctes against oxyradical damage, Biochem Cell Biol, 69, 683, 10.1139/o91-102

Clark, 2000, Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction, Am J Phys, 278, H643

Dore, 1999, Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury, Proc Natl Acad Sci U S A, 96, 2445, 10.1073/pnas.96.5.2445

Dennery, 1995, Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia, Free Radic Biol Med, 19, 395, 10.1016/0891-5849(95)00032-S

Ryter, 2012, Bile pigments in pulmonary and vascular disease, Front Pharmacol, 3, 39, 10.3389/fphar.2012.00039

Schwertner, 1994, Association of low serum concentration of bilirubin with increased risk of coronary artery disease, Clin Chem, 40, 18, 10.1093/clinchem/40.1.18

Breimer, 1995, Serum bilirubin and risk of ischemic heart disease in middle-aged British men, Clin Chem, 41, 1504, 10.1093/clinchem/41.10.1504

Erdogan, 2005, Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women, Atherosclerosis, 184, 431, 10.1016/j.atherosclerosis.2005.05.011

Wang, 2002, Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats, Am J Respir Crit Care Med, 165, 406, 10.1164/ajrccm.165.3.2003149

Wegiel, 2011, Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase, Proc Natl Acad Sci U S A, 108, 18849, 10.1073/pnas.1108571108

Nakao, 2005, Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury, Circulation, 112, 587, 10.1161/CIRCULATIONAHA.104.509778

Ollinger, 2005, Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation, Circulation, 112, 1030, 10.1161/CIRCULATIONAHA.104.528802

Jeney, 2002, Pro-oxidant and cytotoxic effects of circulating heme, Blood, 100, 879, 10.1182/blood.V100.3.879

Belcher, 2010, Heme degradation and vascular injury, Antioxid Redox Signal, 12, 233, 10.1089/ars.2009.2822

Vinchi, 2013, Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases, Circulation, 127, 1317, 10.1161/CIRCULATIONAHA.112.130179

Schaer, 2013, Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins, Blood, 121, 1276, 10.1182/blood-2012-11-451229

Vile, 1993, Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin, J Biol Chem, 268, 14678, 10.1016/S0021-9258(18)82386-9

Vile, 1994, Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts, Proc Natl Acad Sci U S A, 91, 2607, 10.1073/pnas.91.7.2607

Gozzelino, 2010, Mechanisms of cell protection by heme oxygenase-1, Annu Rev Pharmacol Toxicol, 50, 323, 10.1146/annurev.pharmtox.010909.105600

Gumienna-Kontecka, 2014, Iron chelating strategies in systemic metal overload, neurodegeneration and cancer, Curr Med Chem, 21, 3741, 10.2174/0929867321666140706143402

Ward, 2015, Neurodegenerative diseases and therapeutic strategies using iron chelators, J Trace Elem Med Biol, 31, 267, 10.1016/j.jtemb.2014.12.012

Schipper, 2009, Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD, Curr Alzheimer Res, 6, 424, 10.2174/156720509789207985

Mayr, 2006, Effects of carbon monoxide inhalation during experimental endotoxemia in humans, Am J Respir Crit Care Med, 171, 354, 10.1164/rccm.200404-446OC

Bathoorn, 2007, Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study, Eur Respir J, 30, 1131, 10.1183/09031936.00163206

Levitt, 2015, Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function, Clin Pharm, 7, 37

Belcher, 2013, MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice, Blood, 122, 2757, 10.1182/blood-2013-02-486282