Targeting NFATc4 attenuates non-alcoholic steatohepatitis in mice

Journal of Hepatology - Tập 73 - Trang 1333-1346 - 2020
Meng Du1,2, Xiaojing Wang3, Lin Yuan1,2, Bing Liu1,2, Xiaoxiang Mao1,2, Dandan Huang1,2, Liu Yang2, Kun Huang2, Fengxiao Zhang1,2, Yan Wang2, Xi Luo1,2, Cheng Wang1,2, Jiangtong Peng1,2, Minglu Liang2, Dan Huang2, Kai Huang1,2
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
3Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Tài liệu tham khảo

Michelotti, 2013, NAFLD, NASH and liver cancer, Nat Rev Gastroenterol Hepatol, 10, 656, 10.1038/nrgastro.2013.183 Marra, 2008, Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis, Trends Mol Med, 14, 72, 10.1016/j.molmed.2007.12.003 Wree, 2013, From NAFLD to NASH to cirrhosis–new insights into disease mechanisms, Nat Rev Gastroenterol Hepatol, 10, 627, 10.1038/nrgastro.2013.149 Tilg, 2010, Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis, Hepatology, 52, 1836, 10.1002/hep.24001 Clark, 2003, Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis, JAMA, 289, 3000, 10.1001/jama.289.22.3000 Sanyal, 2001, Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities, Gastroenterology, 120, 1183, 10.1053/gast.2001.23256 Kojima, 2007, Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis, Alcohol Clin Exp Res, 31, S61, 10.1111/j.1530-0277.2006.00288.x Rao, 1997, Transcription factors of the NFAT family: regulation and function, Annu Rev Immunol, 15, 707, 10.1146/annurev.immunol.15.1.707 Lopez-Rodriguez, 1999, NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun, Proc Natl Acad Sci U S A, 96, 7214, 10.1073/pnas.96.13.7214 Timmerman, 1996, Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression, Nature, 383, 837, 10.1038/383837a0 Crabtree, 1994, Signal transmission between the plasma membrane and nucleus of T lymphocytes, Annu Rev Biochem, 63, 1045, 10.1146/annurev.bi.63.070194.005145 Wu, 2007, NFAT signaling and the invention of vertebrates, Trends Cell Biol, 17, 251, 10.1016/j.tcb.2007.04.006 Schulz, 2004, Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development, Dev Biol, 266, 1, 10.1016/j.ydbio.2003.10.008 Ranger, 1998, The transcription factor NF-ATc is essential for cardiac valve formation, Nature, 392, 186, 10.1038/32426 Liu, 2012, Interaction between NFkappaB and NFAT coordinates cardiac hypertrophy and pathological remodeling, Circ Res, 110, 1077, 10.1161/CIRCRESAHA.111.260729 Ho, 1998, A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis, Proc Natl Acad Sci U S A, 95, 15537, 10.1073/pnas.95.26.15537 Yang, 2006, Role of transcription factor NFAT in glucose and insulin homeostasis, Mol Cell Biol, 26, 7372, 10.1128/MCB.00580-06 Huang, 2017, PARP1-mediated PPARalpha poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease, J Hepatol, 66, 962, 10.1016/j.jhep.2016.11.020 Syn, 2010, Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease, Hepatology, 51, 1998, 10.1002/hep.23599 Ray, 2010, Isolation of mouse peritoneal cavity cells, J Vis Exp, 35, 1488 Yamaguchi, 2007, Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis, Hepatology, 45, 1366, 10.1002/hep.21655 Sahai, 2004, Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin, Am J Physiol Gastrointest Liver Physiol, 287, G1035, 10.1152/ajpgi.00199.2004 Larter, 2008, Animal models of NASH: getting both pathology and metabolic context right, J Gastroenterol Hepatol, 23, 1635, 10.1111/j.1440-1746.2008.05543.x Clapper, 2013, Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment, Am J Physiol Gastrointest Liver Physiol, 305, G483, 10.1152/ajpgi.00079.2013 Molkentin, 1998, A calcineurin-dependent transcriptional pathway for cardiac hypertrophy, Cell, 93, 215, 10.1016/S0092-8674(00)81573-1 Day, 1998, Steatohepatitis: a tale of two “hits”?, Gastroenterology, 114, 842, 10.1016/S0016-5085(98)70599-2 Lebensztejn, 2016, Hepatokines and non-alcoholic fatty liver disease, Acta Biochim Pol, 63, 459, 10.18388/abp.2016_1252 Bohinc, 2012, Mechanisms of disease progression in NASH: new paradigms, Clin Liver Dis, 16, 549, 10.1016/j.cld.2012.05.002 Chabas, 2001, The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease, Science, 294, 1731, 10.1126/science.1062960 Rangaswami, 2006, Osteopontin: role in cell signaling and cancer progression, Trends Cell Biol, 16, 79, 10.1016/j.tcb.2005.12.005 Miyazaki, 2008, Corneal wound healing in an osteopontin-deficient mouse, Invest Ophthalmol Vis Sci, 49, 1367, 10.1167/iovs.07-1007 Patouraux, 2012, The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease, PLoS One, 7, e35612, 10.1371/journal.pone.0035612 Coombes, 2015, Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice, Gut, 64, 1120, 10.1136/gutjnl-2013-306484 Bertola, 2009, Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity, Diabetes, 58, 125, 10.2337/db08-0400 Many, 2016, OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages, Exp Physiol, 101, 1285, 10.1113/EP085768 Nilsson-Berglund, 2010, Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia, Arterioscler Thromb Vasc Biol, 30, 218, 10.1161/ATVBAHA.109.199299 Willingham, 2005, A strategy for probing the function of noncoding RNAs finds a repressor of NFAT, Science, 309, 1570, 10.1126/science.1115901 Sharma, 2011, Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex, Proc Natl Acad Sci U S A, 108, 11381, 10.1073/pnas.1019711108 Zimprich, 2004, Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology, Neuron, 44, 601, 10.1016/j.neuron.2004.11.005 Barrett, 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease, Nat Genet, 40, 955, 10.1038/ng.175 Abdelmegeed, 2011, PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver, J Nutr, 141, 603 Pawlak, 2015, Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease, J Hepatol, 62, 720, 10.1016/j.jhep.2014.10.039 Refolo, 2020, Inflammatory mechanisms of HCC development, Cancers, 12, 641, 10.3390/cancers12030641 Ruan, 2020, Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma, Int J Cancer, 147, 1519, 10.1002/ijc.32899