Targeting FTO by Dac51 contributes to attenuating DSS-induced colitis

Ng, 2013, Epidemiologic Study Study, Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study, Gastroenterology, 145, 158, 10.1053/j.gastro.2013.04.007 Ng, 2017, Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies, Lancet, 390, 2769, 10.1016/S0140-6736(17)32448-0 Cho, 2008, The genetics and immunopathogenesis of inflammatory bowel disease, Nat. Rev.Immunol, 8, 458, 10.1038/nri2340 Cohen, 2019, Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-Based Therapies for Inflammatory Bowel Diseases, Gastroenterology, 156, 2174, 10.1053/j.gastro.2019.03.017 Munkholm, 2003, Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease, Aliment Pharmacol. Ther., 18, 1, 10.1046/j.1365-2036.18.s2.2.x Triantafillidis, 2009, Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies, Anticancer Res., 29, 2727 Detel, 2016, Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution, J. Physiol. Biochem., 72, 405, 10.1007/s13105-016-0491-7 Desrosiers, 1974, Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells, Proc. Natl. Acad. Sci. USA, 71, 3971, 10.1073/pnas.71.10.3971 Dominissini, 2012, Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq, Nature, 485, 201, 10.1038/nature11112 Meyer, 2012, Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons, Cell, 149, 1635, 10.1016/j.cell.2012.05.003 Jia, 2011, N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO, Nat. Chem. Biol., 7, 885, 10.1038/nchembio.687 Batista, 2014, m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells, Cell Stem Cell, 15, 707, 10.1016/j.stem.2014.09.019 Yao, 2018, Mettl3-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells, Cell Res., 28, 952, 10.1038/s41422-018-0062-2 Li, 2017, m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways, Nature, 548, 338, 10.1038/nature23450 Zheng, 2013, ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility, Mol. Cell, 49, 18, 10.1016/j.molcel.2012.10.015 Zaccara, 2019, Reading, writing and erasing mRNA methylation, Nat. Rev. Mol Cell Biol., 20, 608, 10.1038/s41580-019-0168-5 Weng, 2018, METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification, Cell Stem Cell, 22, 191, 10.1016/j.stem.2017.11.016 Chen, 2018, RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2, Hepatology, 67, 2254, 10.1002/hep.29683 Wang, 2020, METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance, Gut, 69, 1193, 10.1136/gutjnl-2019-319639 Chen, 2021, RNA N(6)-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m(6)A-GLUT1-mTORC1 Axis and Is a Therapeutic Target, Gastroenterology, 160, 1284, 10.1053/j.gastro.2020.11.013 Han, 2020, YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness, EMBO Rep., 21, e49229, 10.15252/embr.201949229 Chen, 2021, m(6)A Modification Mediates Mucosal Immune Microenvironment and Therapeutic Response in Inflammatory Bowel Disease, Front. Cell Dev. Biol., 9 Nie, 2021, A Broad m6A Modification Landscape in Inflammatory Bowel Disease, Front. Cell Dev. Biol., 9 Lu, 2020, A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m(6)A Methyltransferase Component METTL14 in T Cells, CellMol Gastroenterol. Hepatol., 10, 747 Zhang, 2022, m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-kappaB-mediated antiapoptotic pathway, Sci. Adv., 8, eabl5723, 10.1126/sciadv.abl5723 Zhou, 2021, m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity, Sci. Adv., 7, 10.1126/sciadv.abg0470 Chen, 2020, An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients, Pharmacogenom. J., 20, 505, 10.1038/s41397-019-0126-9 Sato, 2017, NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases, Intest. Res., 15, 328, 10.5217/ir.2017.15.3.328 Kim, 2017, A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD, Gut, 66, 1926, 10.1136/gutjnl-2016-311921 Chang, 2020, Genotype-based Treatment With Thiopurine Reduces Incidence of Myelosuppression in Patients With Inflammatory Bowel Diseases, Clin. Gastroenterol. Hepatol., 18, 2010, 10.1016/j.cgh.2019.08.034 Dragasevic, 2020, Metabolic Syndrome in Inflammatory Bowel Disease: Association with Genetic Markers of Obesity and Inflammation, Metab. Syndr. Relat. Disord., 18, 31, 10.1089/met.2019.0090 Jin, 2016, Pharmacological effects of berberine and its derivatives: a patent update, Expert Opin. Ther. Pat., 26, 229, 10.1517/13543776.2016.1118060 Chen, 2021, Upregulation of lncRNA NIFK-AS1 in hepatocellular carcinoma by m(6)A methylation promotes disease progression and sorafenib resistance, Hum. Cell, 34, 1800, 10.1007/s13577-021-00587-z Zheng, 2021, Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis, Int .Immunopharmacol., 101 Sakatani, 1987, Conductivity of dorsal column fibers during experimental spinal cord compression and after decompression at various stimulus frequencies, Cent. Nerv. Syst. Trauma, 4, 161, 10.1089/cns.1987.4.161 Jia, 2008, Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO, FEBS Lett., 582, 3313, 10.1016/j.febslet.2008.08.019 Xiang, 2017, RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response, Nature, 543, 573, 10.1038/nature21671 Su, 2018, R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling, Cell, 172, 90, 10.1016/j.cell.2017.11.031 Li, 2022, FTO in cancer: functions, molecular mechanisms, and therapeutic implications, Trends Cancer, 8, 598, 10.1016/j.trecan.2022.02.010 Huang, 2019, Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia, Cancer Cell, 35, 677, 10.1016/j.ccell.2019.03.006 Huff, 2021, m(6)A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells, ACS Chem. Biol., 16, 324, 10.1021/acschembio.0c00841 Liu, 2021, Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance, CellMetab, 33, 1221