Targeting Chemokine Receptor CCR4 in Adult T-Cell Leukemia-Lymphoma and Other T-Cell Lymphomas
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• Yamamoto K, Utsunomiya A, Tobinai K, et al. Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol. 2010;28:1591–8. This manuscript describes the results of a phase I study of mogamulizumab (KW-0761) in ATL and PTCL, showing encouraging therapeutic efficacy with acceptable toxicity profiles.
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• Ishida T, Joh T, Uike N, et al. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol. 2012;30:837–42. This manuscript describes the results of a phase II study of mogamulizumab/KW-0761 in relapsed patients with ATL, yielding a best overall response rate of 50 % and median progression-free survival of 5.2 months.
Duvic M, Pinter-Brown L, Foss FM, et al.: Results of a phase 1/2 study for KW-0761, a monoclonal antibody directed against CC chemokine receptor type 4 (CCR4), in CTCL patients. [abstract 962]. Presented at the 52nd Annual Meeting of the American Society of Hematology. Orlando, USA; December 4–7, 2010.