Targeting Cancer Cell Dormancy

Trends in Pharmacological Sciences - Tập 40 Số 2 - Trang 128-141 - 2019
Ariadna Recasens1, Lenka Munoz1
1Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, NSW 2006, Australia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Manjili, 2017, Tumor dormancy and relapse: from a natural byproduct of evolution to a disease state, Cancer Res., 77, 2564, 10.1158/0008-5472.CAN-17-0068

Giancotti, 2013, Mechanisms governing metastatic dormancy and reactivation, Cell, 155, 750, 10.1016/j.cell.2013.10.029

Galvao, 2014, Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process, Proc. Natl. Acad. Sci. U. S. A., 111, E4214, 10.1073/pnas.1414389111

Malladi, 2016, Metastatic latency and immune evasion through autocrine inhibition of WNT, Cell, 165, 45, 10.1016/j.cell.2016.02.025

Roesch, 2010, A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth, Cell, 141, 583, 10.1016/j.cell.2010.04.020

Chen, 2012, A restricted cell population propagates glioblastoma growth after chemotherapy, Nature, 488, 522, 10.1038/nature11287

Vanner, 2014, Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma, Cancer Cell, 26, 33, 10.1016/j.ccr.2014.05.005

Unnikrishnan, 2017, Integrative genomics identifies the molecular basis of resistance to azacitidine therapy in myelodysplastic syndromes, Cell Rep., 20, 572, 10.1016/j.celrep.2017.06.067

Meldi, 2015, Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia, J. Clin. Invest., 125, 1857, 10.1172/JCI78752

Puig, 2018, TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence, J. Clin. Invest., 128, 3887, 10.1172/JCI96393

Krall, 2018, The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy, Sci. Transl. Med., 10, 10.1126/scitranslmed.aan3464

Kreso, 2013, Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer, Science, 339, 543, 10.1126/science.1227670

Luskin, 2018, Targeting minimal residual disease: a path to cure?, Nat. Rev. Cancer, 18, 255, 10.1038/nrc.2017.125

Sosa, 2014, Mechanisms of disseminated cancer cell dormancy: an awakening field, Nat. Rev. Cancer, 14, 611, 10.1038/nrc3793

Koebel, 2007, Adaptive immunity maintains occult cancer in an equilibrium state, Nature, 450, 903, 10.1038/nature06309

Teng, 2008, Immune-mediated dormancy: an equilibrium with cancer, J. Leukoc. Biol., 84, 988, 10.1189/jlb.1107774

Nobre, 2018, The different routes to metastasis via hypoxia-regulated programs, Trends Cell Biol., 28, 941, 10.1016/j.tcb.2018.06.008

Romero, 2014, Metastases in immune-mediated dormancy: a new opportunity for targeting cancer, Cancer Res., 74, 6750, 10.1158/0008-5472.CAN-14-2406

Maccalli, 2018, The role of cancer stem cells in the modulation of anti-tumor immune responses, Semin. Cancer Biol., 53, 189, 10.1016/j.semcancer.2018.09.006

Aguirre-Ghiso, 2018, Emerging topics on disseminated cancer cell dormancy and the paradigm of metastasis, Annu. Rev. Cancer Biol., 2, 377, 10.1146/annurev-cancerbio-030617-050446

Manjili, 2014, The inherent premise of immunotherapy for cancer dormancy, Cancer Res., 74, 6745, 10.1158/0008-5472.CAN-14-2440

Sharma, 2010, A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations, Cell, 141, 69, 10.1016/j.cell.2010.02.027

Raha, 2014, The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation, Cancer Res., 74, 3579, 10.1158/0008-5472.CAN-13-3456

Saito, 2010, Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells, Sci. Transl. Med., 2, 17ra9, 10.1126/scitranslmed.3000349

Liau, 2017, Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance, Cell Stem Cell, 20, 233, 10.1016/j.stem.2016.11.003

Abravanel, 2015, Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy, J. Clin. Invest., 125, 2484, 10.1172/JCI74883

Sadasivam, 2013, The DREAM complex: master coordinator of cell cycle-dependent gene expression, Nat. Rev. Cancer, 13, 585, 10.1038/nrc3556

Iness, 2018, The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb, Oncogene, 10.1038/s41388-018-0490-y

Litovchick, 2011, DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly, Genes Dev., 25, 801, 10.1101/gad.2034211

Chen, 2013, Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle, Mol. Cell, 52, 87, 10.1016/j.molcel.2013.09.009

Soppa, 2014, The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation, Cell Cycle, 13, 2084, 10.4161/cc.29104

MacDonald, 2017, A systematic analysis of negative growth control implicates the DREAM complex in cancer cell dormancy, Mol. Cancer Res., 15, 371, 10.1158/1541-7786.MCR-16-0323-T

Deng, 2009, Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species, Cancer Res., 69, 3317, 10.1158/0008-5472.CAN-08-2903

Ewton, 2011, Inactivation of Mirk/Dyrk1b kinase targets quiescent pancreatic cancer cells, Mol. Cancer Ther., 10, 2104, 10.1158/1535-7163.MCT-11-0498

Hu, 2010, Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/Rb2, Int. J. Cancer, 129, 307, 10.1002/ijc.25692

Aguirre-Ghiso, 2007, Models, mechanisms and clinical evidence for cancer dormancy, Nat. Rev. Cancer, 7, 834, 10.1038/nrc2256

Aguirre-Ghiso, 2003, ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK), Cancer Res., 63, 1684

Yu-Lee, 2018, Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFbetaRIII-p38MAPK-pS249/T252RB pathway, Cancer Res., 78, 2911, 10.1158/0008-5472.CAN-17-1051

Aguirre Ghiso, 1999, Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling, J. Cell Biol., 147, 89, 10.1083/jcb.147.1.89

Bragado, 2013, TGF-beta2 dictates disseminated tumour cell fate in target organs through TGF-beta-RIII and p38alpha/beta signalling, Nat. Cell Biol., 15, 1351, 10.1038/ncb2861

Sosa, 2015, NR2F1 controls tumour cell dormancy via SOX9- and RARbeta-driven quiescence programmes, Nat. Commun., 6, 6170, 10.1038/ncomms7170

Schewe, 2008, ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo, Proc. Natl. Acad. Sci. U. S. A., 105, 10519, 10.1073/pnas.0800939105

Ranganathan, 2006, Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase–like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells, Cancer Res., 66, 1702, 10.1158/0008-5472.CAN-05-3092

Jo, 2008, Cancer cell-derived clusterin modulates the phosphatidylinositol 3′-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation, Mol. Cell. Biol., 28, 4285, 10.1128/MCB.01240-07

Vera-Ramirez, 2018, Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence, Nat. Commun., 9, 1944, 10.1038/s41467-018-04070-6

Aqbi, 2018, Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy, Oncotarget, 9, 22113, 10.18632/oncotarget.25197

El-Shennawy, 2018, Coactivation of estrogen receptor and IKKbeta induces a dormant metastatic phenotype in ER-positive breast cancer, Cancer Res., 78, 974, 10.1158/0008-5472.CAN-17-1686

Gawrzak, 2018, MSK1 regulates luminal cell differentiation and metastatic dormancy in ER(+) breast cancer, Nat. Cell Biol., 20, 211, 10.1038/s41556-017-0021-z

Shiozawa, 2008, The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites, Leukemia, 22, 941, 10.1038/leu.2008.48

Shiozawa, 2010, GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche, Neoplasia, 12, 116, 10.1593/neo.91384

Cackowski, 2017, Mer tyrosine kinase regulates disseminated prostate cancer cellular dormancy, J. Cell. Biochem., 118, 891, 10.1002/jcb.25768

Yu-Lee, 2018, Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII–p38MAPK–pS249/T252RB pathway, Cancer Res., 78, 2911, 10.1158/0008-5472.CAN-17-1051

Kobayashi, 2011, Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone, J. Exp. Med., 208, 2641, 10.1084/jem.20110840

Gao, 2012, The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites, Cell, 150, 764, 10.1016/j.cell.2012.06.035

Sosa, 2011, ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease, Clin. Cancer Res., 17, 5850, 10.1158/1078-0432.CCR-10-2574

Barkan, 2008, Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton, Cancer Res., 68, 6241, 10.1158/0008-5472.CAN-07-6849

Barkan, 2010, Metastatic growth from dormant cells induced by a Col-I–enriched fibrotic environment, Cancer Res., 70, 5706, 10.1158/0008-5472.CAN-09-2356

Viale, 2014, Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function, Nature, 514, 628, 10.1038/nature13611

Rajbhandari, 2017, Autocrine IGF1 signaling mediates pancreatic tumor cell dormancy in the absence of oncogenic drivers, Cell Rep., 18, 2243, 10.1016/j.celrep.2017.02.013

Milanovic, 2018, Senescence-associated reprogramming promotes cancer stemness, Nature, 553, 96, 10.1038/nature25167

Gewirtz, 2009, Autophagy, senescence and tumor dormancy in cancer therapy, Autophagy, 5, 1232, 10.4161/auto.5.8.9896

Wang, 2011, Survivin and escaping in therapy-induced cellular senescence, Int. J. Cancer, 128, 1546, 10.1002/ijc.25482

Fisher, 2017, Persistent bacterial infections and persister cells, Nat. Rev. Microbiol., 15, 453, 10.1038/nrmicro.2017.42

Levin-Reisman, 2017, Antibiotic tolerance facilitates the evolution of resistance, Science, 355, 826, 10.1126/science.aaj2191

Roesch, 2013, Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells, Cancer Cell, 23, 811, 10.1016/j.ccr.2013.05.003

Goldman, 2015, Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition, Nat. Commun., 6, 10.1038/ncomms7139

Holohan, 2013, Cancer drug resistance: an evolving paradigm, Nat. Rev. Cancer, 13, 714, 10.1038/nrc3599

Hangauer, 2017, Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition, Nature, 551, 247, 10.1038/nature24297

Shaffer, 2017, Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance, Nature, 546, 431, 10.1038/nature22794

Vinogradova, 2016, An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells, Nat. Chem. Biol., 12, 531, 10.1038/nchembio.2085

Staberg, 2018, Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B, Mol. Oncol., 12, 406, 10.1002/1878-0261.12174

Dalvi, 2017, Taxane-platin-resistant lung cancers co-develop hypersensitivity to JumonjiC demethylase inhibitors, Cell Rep., 19, 1669, 10.1016/j.celrep.2017.04.077

Risom, 2018, Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer, Nat. Commun., 9, 10.1038/s41467-018-05729-w

Guler, 2017, Repression of stress-induced LINE-1 expression protects cancer cell subpopulations from lethal drug exposure, Cancer Cell, 32, 221, 10.1016/j.ccell.2017.07.002

Ormerod, 1993, Proliferative behaviour of an oestrogen sensitive rat mammary tumour: evidence for a paracrine interaction between tumour and stroma, Br. J. Cancer, 67, 107, 10.1038/bjc.1993.18

Abderrahman, 2018, Rethinking extended adjuvant antiestrogen therapy to increase survivorship in breast cancer, JAMA Oncol., 4, 15, 10.1001/jamaoncol.2017.3510

Davies, 2013, Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial, Lancet, 381, 805, 10.1016/S0140-6736(12)61963-1

Aguirre Ghiso, 2002, Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo, Oncogene, 21, 2513, 10.1038/sj.onc.1205342

Wang, 1998, Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology, Proc. Natl. Acad. Sci. U. S. A., 95, 14821, 10.1073/pnas.95.25.14821

Wang, 2002, Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts, J. Natl. Cancer Inst., 94, 1494, 10.1093/jnci/94.19.1494

El Touny, 2014, Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells, J. Clin. Invest., 124, 156, 10.1172/JCI70259

Chou, 2017, Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer, Gut, 67, 2142, 10.1136/gutjnl-2017-315144

Bollard, 2017, Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma, Gut, 66, 1286, 10.1136/gutjnl-2016-312268

Wiedemeyer, 2010, Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM, Proc. Natl. Acad. Sci. U. S. A., 107, 11501, 10.1073/pnas.1001613107

O’Leary, 2016, Treating cancer with selective CDK4/6 inhibitors, Nat. Rev. Clin. Oncol., 13, 417, 10.1038/nrclinonc.2016.26

Gao, 2012, The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites, Cell, 150, 764, 10.1016/j.cell.2012.06.035

Buczacki, 2018, Itraconazole targets cell cycle heterogeneity in colorectal cancer, J. Exp. Med., 251, 1891, 10.1084/jem.20171385

Beliveau, 2010, Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo, Genes Dev., 24, 2800, 10.1101/gad.1990410

Liu, 2018, STAT3/p53 pathway activation disrupts IFN-beta-induced dormancy in tumor-repopulating cells, J. Clin. Invest., 128, 1057, 10.1172/JCI96329

Ghajar, 2015, Metastasis prevention by targeting the dormant niche, Nat. Rev. Cancer, 15, 238, 10.1038/nrc3910

Linde, 2016, The relationship between dormant cancer cells and their microenvironment, Adv. Cancer Res., 132, 45, 10.1016/bs.acr.2016.07.002

Boyerinas, 2013, Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy, Blood, 121, 4821, 10.1182/blood-2012-12-475483

Saito, 2010, Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML, Nat. Biotechnol., 28, 275, 10.1038/nbt.1607

Di Tullio, 2017, The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia, Nat. Commun., 8, 10.1038/s41467-017-01834-4

Essers, 2009, IFNα activates dormant haematopoietic stem cells in vivo, Nature, 458, 904, 10.1038/nature07815

Sato, 2009, Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion, Nat. Med., 15, 696, 10.1038/nm.1973

Pietras, 2014, Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons, J. Exp. Med., 211, 245, 10.1084/jem.20131043

Boichuk, 2013, The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis, Cancer Res., 73, 5120, 10.1158/0008-5472.CAN-13-0579

Dittmer, 2017, Mechanisms governing metastatic dormancy in breast cancer, Semin. Cancer Biol., 44, 72, 10.1016/j.semcancer.2017.03.006

Wang, 2018, An acquired vulnerability of drug-resistant melanoma with therapeutic potential, Cell, 173, 1413, 10.1016/j.cell.2018.04.012

McGrath, 2015, Targeting histone lysine methylation in cancer, Pharmacol. Ther., 150, 1, 10.1016/j.pharmthera.2015.01.002

McAllister, 2016, Recent progress in histone demethylase inhibitors, J. Med. Chem., 59, 1308, 10.1021/acs.jmedchem.5b01758

Kruidenier, 2012, A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response, Nature, 488, 404, 10.1038/nature11262

Heinemann, 2014, Inhibition of demethylases by GSK-J1/J4, Nature, 514, E1, 10.1038/nature13688

Dalvi, 2017, Taxane-platin-resistant lung cancers co-develop hypersensitivity to JumonjiC demethylase inhibitors, Cell Rep., 19, 1669, 10.1016/j.celrep.2017.04.077

Suraweera, 2018, Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: achieving the full therapeutic potential of HDACi, Front. Oncol., 8, 92, 10.3389/fonc.2018.00092

Yang, 2014, Regulation of ferroptotic cancer cell death by GPX4, Cell, 156, 317, 10.1016/j.cell.2013.12.010

Lee, 2012, Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks, Cell, 149, 780, 10.1016/j.cell.2012.03.031

Goss, 2010, Does tumour dormancy offer a therapeutic target?, Nat. Rev. Cancer, 10, 871, 10.1038/nrc2933