Targeted therapy in melanoma – the role of BRAF, RAS and KIT mutations

European Journal of Cancer, Supplement - Tập 11 - Trang 92-96 - 2013
Simone M. Goldinger1, Carla Murer1, Pascale Stieger1, Reinhard Dummer1
1University Hospital, Department of Dermatology, Zurich, Switzerland

Tài liệu tham khảo

Shakhova, 2012, Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma, Nat Cell Biol, 14, 882, 10.1038/ncb2535 Omholt, 2011, KIT pathway alterations in mucosal melanomas of the vulva and other sites, Clin Cancer Res, 17, 3933, 10.1158/1078-0432.CCR-10-2917 Schoenewolf, 2012, Sinonasal, genital and acrolentiginous melanomas show distinct characteristics of KIT expression and mutations, Eur J Cancer, 48, 1842, 10.1016/j.ejca.2012.02.049 Van Raamsdonk, 2009, Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi, Nature, 457, 599, 10.1038/nature07586 Van Raamsdonk, 2010, Mutations in GNA11 in uveal melanoma, N Engl J Med, 363, 2191, 10.1056/NEJMoa1000584 Krauthammer, 2012, Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma, Nat Genet, 44, 1006, 10.1038/ng.2359 Hodis, 2012, A landscape of driver mutations in melanoma, Cell, 150, 251, 10.1016/j.cell.2012.06.024 Huang, 2013, Highly recurrent TERT promoter mutations in human melanoma, Science, 339, 957, 10.1126/science.1229259 Dummer, 2013, Initial results from a phase I, open-label, dose escalation study of the oral BRAF inhibitor LGX818 in patients with BRAF V600 mutant advanced or metastatic melanoma, J Clin Oncol, 31, 10.1200/jco.2013.31.15_suppl.9028 Bollag, 2010, Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma, Nature, 467, 596, 10.1038/nature09454 Kefford, 2010, Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors, J Clin Oncol, 28, 10.1200/jco.2010.28.15_suppl.8503 Flaherty, 2010, Inhibition of mutated, activated BRAF in metastatic melanoma, N Engl J Med, 363, 809, 10.1056/NEJMoa1002011 Long, 2012, Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial, Lancet Oncol, 13, 1087, 10.1016/S1470-2045(12)70431-X Ribas, 2011, Brim 2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAFV600E mutation-positive metastatic melanoma, J Clin Oncol, 29, 10.1200/jco.2011.29.15_suppl.8509 Sosman, 2012, Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib, N Engl J Med, 366, 707, 10.1056/NEJMoa1112302 Chapman, 2011, Improved survival with vemurafenib in melanoma with BRAF V600E mutation, N Engl J Med, 364, 2507, 10.1056/NEJMoa1103782 Chapman, 2012, Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma, J Clin Oncol, 10.1200/jco.2012.30.15_suppl.8502 Hauschild, 2012, Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial, Lancet, 380, 358, 10.1016/S0140-6736(12)60868-X Long, 2010, Phase 1/2 study of GSK2118436, a selective inhibitor of V600 mutant (mut) BRAF kinase: evidence of activity in melanoma brain metastases (mets), Ann Oncol, 21 Pratilas, 2009, (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway, Proc Natl Acad Sci U S A, 106, 4519, 10.1073/pnas.0900780106 Kirkwood, 2012, Phase II, open-label, randomized trial of the MEK1/2 Inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma, Clin Cancer Res, 18, 555, 10.1158/1078-0432.CCR-11-1491 Middleton, 2013, Phase II double-blind, randomized study of selumetinib (SEL) plus dacarbazine (DTIC) versus placebo (PBO) plus DTIC as first-line treatment for advanced BRAF-mutant cutaneous or unknown primary melanoma, J Clin Oncol, 31, 10.1200/jco.2013.31.15_suppl.9004 Carvajal, 2013, Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma (UM), J Clin Oncol, 31, 10.1200/jco.2013.31.15_suppl.cra9003 Flaherty, 2012, Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations, N Engl J Med, 367, 1694, 10.1056/NEJMoa1210093 Lito, 2012, Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas, Cancer Cell, 22, 668, 10.1016/j.ccr.2012.10.009 Ascierto, 2013, MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study, Lancet Oncol, 14, 249, 10.1016/S1470-2045(13)70024-X Margolin, 2012, Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial, Lancet Oncol, 13, 459, 10.1016/S1470-2045(12)70090-6 Dummer, 2012, Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann Oncol, 23, 10.1093/annonc/mds229 Rinderknecht, 2013, RASopathic skin eruptions during vemurafenib therapy, PLoS One, 3, e58721, 10.1371/journal.pone.0058721 Anforth, 2012, Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanoma, Br J Dermatol, 167, 1153, 10.1111/j.1365-2133.2012.11155.x Dummer, 2012, Ultraviolet A and photosensitivity during vemurafenib therapy, N Engl J Med, 366, 480, 10.1056/NEJMc1113752 Adjei, 2008, Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers, J Clin Oncol, 26, 2139, 10.1200/JCO.2007.14.4956 Eggmann, 2012, Self limiting serous retinopathy-like toxicity during MEK kinase inhibition, EADO, P32 Belloni, 2012, Cutaneous drug eruptions associated with the use of new oncological drugs, Chem Immunol Allergy, 97, 191, 10.1159/000335632 Schad, 2010, Mitogen-activated protein/extracellular signal-regulated kinase kinase inhibition results in biphasic alteration of epidermal homeostasis with keratinocytic apoptosis and pigmentation disorders, Clin Cancer Res, 16, 1058, 10.1158/1078-0432.CCR-09-1766 Dummer, 2012, Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights, Curr Opin Oncol, 24, 150, 10.1097/CCO.0b013e32834fca92 Das Thakur, 2013, Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance, Nature, 494, 251, 10.1038/nature11814 Hodi, 2008, Major response to imatinib mesylate in KIT-mutated melanoma, J Clin Oncol, 26, 2046, 10.1200/JCO.2007.14.0707 Curtin, 2006, Somatic activation of KIT in distinct subtypes of melanoma, J Clin Oncol, 24, 4340, 10.1200/JCO.2006.06.2984 Carvajal, 2011, KIT as a therapeutic target in metastatic melanoma, JAMA, 305, 2327, 10.1001/jama.2011.746 Guo, 2011, Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification, J Clin Oncol, 29, 2904, 10.1200/JCO.2010.33.9275