TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

Egyptian Journal of Medical Human Genetics - Tập 22 Số 1 - 2021
Estela Morales Peralta1, Yaíma Zúñiga Rosales2, Teresa Collazo Mesa2, Elvia Nelmi Santos González2, Yadira Hernández Pérez2, María de los Ángeles González Torres2, Hilda Roblejo Balbuena2, Beatríz Marcheco Teruel2
1Facultad de Ciencias Médicas 10 de Octubre, Universidad de Ciencias Médicas de La Habana, 10 de Octubre CP 10500, Havana, Cuba
2National Center of Medical Genetics of Cuba, Havana, Cuba

Tóm tắt

Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.

Từ khóa


Tài liệu tham khảo

Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P et al (2020) Genomewide association study of severe covid-19 with respiratory failure. N Engl J Med 383(16):1522–1534

Godri Pollitt KJ, Peccia J, Ko AI, Kaminski N, Dela Cruz CS, Nebert DW et al (2020) COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. Hum Genomics 14(1):17

Nussabaum RL, McInnes R, Willard H (2015) Thompson & Thompson genetics in medicine, Eight. Elsevier, Philadelphia, p 546

Murray MF, Kenny EE, Ritchie MD, Rader DJ, Bale AE, Giovanni MA et al (2020) COVID-19 outcomes and the human genome. Genet Med 22(7):1175–1177

Kenney AD, Dowdle JA, Bozzacco L, McMichael TM, St Gelais C, Panfil AR et al (2017) Human genetic determinants of viral diseases. Annu Rev Genet 51:241–263

Ebadi M, Montano-Loza AJ (2020) Perspective: improving vitamin D status in the management of COVID-19. Eur J Clin Nutr 74(6):856–859

Alzaman NS, Dawson-Hughes B, Nelson J, D’Alessio D, Pittas AG (2016) Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation. Am J Clin Nutr 104(1):205–214

Almaguer Mederos L, Cuello Almarales D, Almaguer Gotay D. Rol de los genes ACE2 y TMPRSS2 en la susceptibilidad o gravedad de la COVID-19. Anales de la Academia de Ciencias de Cuba [Internet]. 2020;10(2). Available from: http://www.revistaccuba.cu/index.php/revacc/article/view/799

Xu J, Yang J, Chen J, Luo Q, Zhang Q, Zhang H (2017) Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system. Mol Med Rep 16(5):7432–7438

Santos BR, Mascarenhas LPG, Satler F, Boguszewski MCS, Spritzer PM (2012) Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants. BMC Pediatr 12:62

Pfeffer PE, Hawrylowicz CM (2012) Vitamin D and lung disease. Thorax 67(11):1018

Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 601769 [Internet]. 2021 [cited 2021 Mar 9]. Available from: https://omim.org

Bellamy R, Hill AV (1998) Genetic susceptibility to mycobacteria and other infectious pathogens in humans. Curr Opin Immunol 10(4):483–487

Taylor JA, Hirvonen A, Watson M, Pittman G, Mohler JL, Bell DA (1996) Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Res 56(18):4108

QIAGEN. QIAsymphony® DSP DNA Instructions for Use (Handbook) [Internet]. 2015 [cited 2021 Feb 21]. Available from: www.qiagen.com/HB-0977-004_1069185_151035723_R4_HB_QS_DSP_DNA_Kit_0815_WW.pdf

World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J Am Coll Dent. 2014 Summer;81(3):14–8.

Lardoeyt Ferrrer R. Fundamentos de genética poblacional. La Habana: Editorial Ciencias Médicas; 2016. 366 p.

Plasencia-Urizarri TM, Aguilera-Rodríguez R, Almaguer Mederos LE. Comorbilidades y gravedad clínica de la COVID-19: revisión sistemática y meta-análisis. Rev haban cienc méd [Internet]. 2020 Jun 23;19. Available from: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3389

Morales Peralta E, Alvarez Fornaris MA. COVID-19: aspectos relacionados a la susceptibilidad genética y defectos congénitos. Rev haban cienc méd [Internet]. 2020;19(5). Available from: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3595

Delanghe JR, Speeckaert MM, De Buyzere ML (2020) ACE polymorphism and COVID-19 outcome. Endocrine 70(1):13–14

Thông tin
Thông tin xuất bản

Egyptian Journal of Medical Human Genetics

Tập 22 Số 1

Thông tin tác giả