Tanshinone IIA prevents acute lung injury by regulating macrophage polarization

Fanelli, 2015, Mechanisms and clinical consequences of acute lung injury, Ann Am Thorac Soc, 12, S3, 10.1513/AnnalsATS.201407-340MG Chen, 2020, MiR-222 inhibition alleviates staphylococcal enterotoxin B-induced inflammatory acute lung injury by targeting Foxo3, J Biosci, 45, 65, 10.1007/s12038-020-00037-2 Dias-Freitas, 2016, Molecular mechanisms underlying hyperoxia acute lung injury, Respir Med, 119, 23, 10.1016/j.rmed.2016.08.010 Butt, 2016, Acute lung injury: a clinical and molecular review, Arch Pathol Lab Med, 140, 345, 10.5858/arpa.2015-0519-RA Kim, 2015, Transfusion-related acute lung injury; clinical perspectives, Korean J Anesthesiol, 68, 101, 10.4097/kjae.2015.68.2.101 Aktas, 2020, Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus, Aging Male, 23, 1098, 10.1080/13685538.2019.1678126 Atak, 2019, Diabetes control could through platelet-to-lymphocyte ratio in hemograms, Rev Assoc Med Bras (1992), 65, 38, 10.1590/1806-9282.65.1.38 Duman, 2019, Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus, Afr Health Sci, 19, 1602, 10.4314/ahs.v19i1.35 Kocak, 2019, Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus, Rev Assoc Med Bras (1992), 65, 9, 10.1590/1806-9282.65.1.9 Aktas, 2017, Could red cell distribution width be a marker of thyroid cancer?, J Coll Physicians Surg Pak, 27, 556 Mokra, 2019, Corticosteroids in acute lung injury: the dilemma continues, Int J Mol Sci, 20, 4765, 10.3390/ijms20194765 Chen, 2012, Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats, PLoS ONE, 7, e40165, 10.1371/journal.pone.0040165 Gao, 2012, Cardiovascular actions and therapeutic potential of tanshinone IIA, Atherosclerosis, 220, 3, 10.1016/j.atherosclerosis.2011.06.041 Zhang, 2018, Tanshinone IIA attenuates diabetic peripheral neuropathic pain in experimental rats via inhibiting inflammation, Evid Based Complement Alternat Med, 2018, 2789847 Liu, 2021, Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages, Acta Pharmacol Sin, 42, 987, 10.1038/s41401-020-00535-x Wen, 2021, Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation, Aging (Albany NY), 13, 910, 10.18632/aging.202202 Kulkarni, 2019, Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality, Mucosal Immunol, 12, 545, 10.1038/s41385-018-0115-3 Scozzi, 2019, Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance, Am J Transplant, 19, 1011, 10.1111/ajt.15163 Vannella, 2017, Mechanisms of organ injury and repair by macrophages, Annu Rev Physiol, 79, 593, 10.1146/annurev-physiol-022516-034356 Boniakowski, 2019, SIRT3 regulates macrophage-mediated inflammation in diabetic wound repair, J Invest Dermatol, 139, 2528, 10.1016/j.jid.2019.05.017 Talukdar, 2020, Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19, Biomed Pharmacother, 132, 110886, 10.1016/j.biopha.2020.110886 McCartney SA, Kapur R, Liggitt HD, Baldessari A, Coleman M, Orvis A, et al. Amniotic fluid IL-6 and IL-8 are superior predictors of fetal lung injury compared to maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model. Am J Obstet Gynecol 2021;225(1):89.e1–16. Goodman, 1996, Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome, Am J Respir Crit Care Med, 154, 602, 10.1164/ajrccm.154.3.8810593 Sousa, 2015, Measurement of cytokines and adhesion molecules in the first 72 hours after severe trauma: association with severity and outcome, Dis Markers, 2015, 747036, 10.1155/2015/747036 Liu, 2019, Elevation of serum PARK7 and IL-8 levels is associated with acute lung injury in patients with severe sepsis/septic shock, J Intensive Care Med, 34, 662, 10.1177/0885066617709689 Shen, 2011, Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target, Expert Rev Respir Med, 5, 107, 10.1586/ers.10.80 Alzhrani, 2017, Tanshinone IIA inhibits VEGF secretion and HIF-1α expression in cultured human retinal pigment epithelial cells under hypoxia, Curr Eye Res, 42, 1667, 10.1080/02713683.2017.1355467 Wright, 1990, CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein, Science, 249, 1431, 10.1126/science.1698311 Huang, 2019, M1 macrophage activated by notch signal pathway contributed to ventilator-induced lung injury in chronic obstructive pulmonary disease model, J Surg Res, 244, 358, 10.1016/j.jss.2019.06.060 Doyle, 2006, Toll-like receptors: from the discovery of NFκB to new insights into transcriptional regulations in innate immunity, Biochem Pharmacol, 72, 1102, 10.1016/j.bcp.2006.07.010 Nennig, 2017, The role of NFκB in drug addiction: beyond inflammation, Alcohol Alcohol, 52, 172, 10.1093/alcalc/agw098 Lee, 2019, Hypoxia signaling in human diseases and therapeutic targets, Exp Mol Med, 51, 1, 10.1038/s12276-019-0235-1 D'Ignazio, 2017, Hypoxia and inflammation in cancer, focus on HIF and NF-κB, Biomedicines, 5, 21, 10.3390/biomedicines5020021 Heusinkveld, 2011, M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells, J Immunol, 187, 1157, 10.4049/jimmunol.1100889 Ding, 2021, M2 macrophage-derived G-CSF promotes trophoblasts EMT, invasion and migration via activating PI3K/Akt/Erk1/2 pathway to mediate normal pregnancy, J Cell Mol Med, 25, 2136, 10.1111/jcmm.16191