Tandem trimer pyrrole–imidazole polyamide probes targeting 18 base pairs in human telomere sequences

Chemical Science - Tập 6 Số 4 - Trang 2307-2312
Yusuke Kawamoto1,2,3,4,5, Asuka Sasaki6,7,8,9,10, Kaori Hashiya1,2,3,4,5, Satoru Ide6,7,8,9,10, Toshikazu Bando1,2,3,4,5, Kazuhiro Maeshima6,7,8,9,10, Hiroshi Sugiyama1,11,3,4,5
1Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Sakyo, Japan
2Graduate School of Science
3Japan
4Kyoto 606-8502
5Kyoto University
6Biological Macromolecules Laboratory, Structural Biology Center, National Institute of Genetics, and Department of Genetics, School of Life Science, Graduate University for Advanced Studies (Sokendai), Mishima, Shizuoka 411-8540, Japan
7Graduate University for Advanced Studies (Sokendai)
8National Institute of Genetics, and Department of Genetics
9School of Life Science
10Structural Biology Center
11Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Sakyo, Japan

Tóm tắt

The novel tandem trimer pyrrole-imidazole polyamide probe targeting 18 bp in telomeric repeats visualized telomeres in human cells selectively.

Từ khóa


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