TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer

Oncotarget - Tập 9 Số 71 - Trang 33459-33470 - 2018
Mohamad Elbaz1,2,3, Dinesh K. Ahirwar1,3, Xiaoli Zhang4, Xinyu Zhou5, Maryam B. Lustberg6, Mohd W. Nasser1,3, Konstantin Shilo1,3, Ramesh K. Ganju1,3
1Department of Pathology, Wexner Medical Center, Ohio State University (OSU), Columbus, OH, USA
2Department of Pharmacology, Pharmacy School, Helwan University, Helwan, Egypt
3The Comprehensive Cancer Center, Ohio State University (OSU), Wexner Medical Center, Columbus, OH, USA
4Center for Biostatistics, Ohio State University (OSU), Columbus, OH, USA
5Department of surgery, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
6Department of Internal Medicine, Ohio State University (OSU), Columbus, OH, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Jemal, 2013, Cancer statistics, 2013, CA: a cancer journal for clinicians, 63, 11

Caggiano, 2007, Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype, Cancer, 109, 1721, 10.1002/cncr.22618

Glück, 2013, Molecularly targeted therapies for metastatic triple-negative breast cancer, Breast cancer research and treatment, 1

Gianni, 2011, Triple-negative breast cancer: an unmet medical need, Oncologist, 16, 1, 10.1634/theoncologist.2011-S1-01

Green, 2008, Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer, Journal of Clinical Oncology, 26, 1275, 10.1200/JCO.2007.14.4147

Narod, 2007, Triple-negative breast cancer: clinical features and patterns of recurrence, Clinical cancer research, 13, 4429, 10.1158/1078-0432.CCR-06-3045

Pieńkowski, 2013, Analysis of pattern, time and risk factors influencing recurrence in triple-negative breast cancer patients, Medical Oncology, 30, 1

Prevarskaya, 2011, TRP channels in prostate cancer: the good, the bad and the uglyŒ Asian, Journal of Andrology, 13, 673

Julius, 2002, A unified nomenclature for the superfamily of TRP cation channels, Molecular cell, 9, 229, 10.1016/S1097-2765(02)00448-3

Julius, 1999, A capsaicin-receptor homologue with a high threshold for noxious heat, Nature, 398, 436, 10.1038/18906

Santoni, 2012, The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation, International Journal of Cancer, 131, E1067, 10.1002/ijc.27588

Flores, 2008, TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons, The Journal of Neuroscience, 28, 6231, 10.1523/JNEUROSCI.0504-08.2008

Kojima, 1999, Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I, Nature cell biology, 1, 165, 10.1038/11086

Rassendren, 2006, PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane, Cell calcium, 39, 495, 10.1016/j.ceca.2006.01.009

Limbad, 2011, Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis, Breast cancer research and treatment, 129, 37, 10.1007/s10549-010-1177-4

Desprez, 2007, Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells, Molecular cancer therapeutics, 6, 2921, 10.1158/1535-7163.MCT-07-0371

Steyger, 2008, TRPV4 enhances the cellular uptake of aminoglycoside antibiotics, Journal of cell science, 121, 2871, 10.1242/jcs.023705

Szallasi, 2010, An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients, Breast cancer research and treatment, 123, 725, 10.1007/s10549-009-0674-9

Santoni, 2013, Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents, Carcinogenesis, 34, 48, 10.1093/carcin/bgs328

De Maria, 2006, Chemotherapy resistance of glioblastoma stem cells, Cell Death & Differentiation, 13, 1238, 10.1038/sj.cdd.4401872

Nagamatsu, 2010, Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic beta-cells, Biochem J, 432, 375, 10.1042/BJ20100864

Kojima, 2009, Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic β-cells, Diabetes, 58, 174, 10.2337/db08-0862

Tominaga, 2010, Involvement of TRPV2 activation in intestinal movement through nitric oxide production in mice, The Journal of Neuroscience, 30, 16536, 10.1523/JNEUROSCI.4426-10.2010

Mayer, 2013, Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer, Clinical cancer research, 19, 2723, 10.1158/1078-0432.CCR-12-2986

Slomianny, 2010, Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance, Cancer Research, 70, 1225, 10.1158/0008-5472.CAN-09-2205

Yang, 2010, Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma, Cancer genetics and cytogenetics, 197, 54, 10.1016/j.cancergencyto.2009.08.007

Shimada, 2010, TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer, Urology, 76

Camci, 2014, Do Fasudil, Y-27632 affect the level of transient receptor potential (TRP) gene expressions in breast cancer cell lines?, Tumor Biology, 35, 8033, 10.1007/s13277-014-1752-0

Ouadid-Ahidouch, 2011, High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters, Cellular Physiology and Biochemistry, 28, 813, 10.1159/000335795

Beech, 2011, Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids, British journal of pharmacology, 162, 1509, 10.1111/j.1476-5381.2010.01136.x

De Maria, 2010, TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner, Carcinogenesis, 31, 794, 10.1093/carcin/bgq019

Li, 2015, Novel role of TRPV2 in promoting the cytotoxicity of H 2 O 2-mediated oxidative stress in Human hepatoma cells, Free Radical Biology and Medicine, 89, 1003, 10.1016/j.freeradbiomed.2015.09.020

Lipkowitz, 2010, Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer, Breast disease, 32, 35

Shilo, 2015, RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment, Cancer research, 75, 974, 10.1158/0008-5472.CAN-14-2161

Zou, 2012, S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways, Cancer Research, 72, 604, 10.1158/0008-5472.CAN-11-0669

Ganju, 2011, Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion, PloS one, 6, e23901, 10.1371/journal.pone.0023901

Carson, 2015, Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer, Molecular oncology, 9, 906, 10.1016/j.molonc.2014.12.010