TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

Science advances - Tập 6 Số 46 - 2020
Cheng‐Chang Chen1, Einar Krogsaeter2, Elisabeth Butz3, Yanfen Li1, Rosa Puertollano4, Christian Wahl‐Schott5, Martin Biel1, Christian Grimm2
1Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany
2Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany
3Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
4Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
5Institute for Neurophysiology, Hannover Medical School, Hannover, Germany

Tóm tắt

Protein trafficking is mediated by tubulation/vesiculation of endosomes and is regulated by osmo/mechanosensitive TRPML2.

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Science advances

Tập 6 Số 46

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