TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling

Alan R. Wolfe1,2, R. Jeffrey Neitz2,3, Mark Burlingame3, Brian M. Suzuki2,4, KC Lim2,4, Mark Scheideler5, David L. Nelson6, Leslie Z. Benet1,2, Conor R. Caffrey2,4
1Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, 533 Parnassus Ave, San Francisco, CA, 94143, USA
2Center for Discovery and Innovation in Parasitic Diseases, University of California, 1700 4th St, San Francisco, CA, 94158, USA
3Department of Pharmaceutical Chemistry, University of California, 1700 4th St, San Francisco, CA, 94158, USA
4Department of Pathology, University of California, 1700 4th St, San Francisco, CA, 94158, USA
5Human First Therapeutics LLC, 9600 Dewitt Drive, Ste 1, Silver Spring, MD, 20910, USA
6Pro-Rectory of Research and Graduate Study, Federal University of the Valleys of Jequitinhonha and Mucuri, 39100-000, Diamantina, MG, Brazil

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