TOX3 inhibits cancer cell migration and invasion via transcriptional regulation of SNAI1 and SNAI2 in clear cell renal cell carcinoma

Cancer Letters - Tập 449 - Trang 76-86 - 2019
Bo Jiang1, Wei Chen1, Haixiang Qin1, Wenli Diao1, Binghua Li2, Wenmin Cao1, Zhenxing Zhang3, Wei Qi3, Jie Gao1, Mengxia Chen1, Xiaozhi Zhao1, Hongqian Guo1
1Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, PR China
2Department of Hepatobiliary Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, PR China
3Department of Urology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008, Jiangsu, PR China

Tài liệu tham khảo

Siegel, 2016, Cancer statistics, 2016, Ca - Cancer J. Clin., 66, 7, 10.3322/caac.21332 2002, Genetics of kidney cancer (renal cell cancer) (PDQ(R)): health Professional Version Motzer, 2009, Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma, J. Clin. Oncol., 27, 3584, 10.1200/JCO.2008.20.1293 Sternberg, 2010, Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial, J. Clin. Oncol., 28, 1061, 10.1200/JCO.2009.23.9764 Randall, 2014, Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art, Cancer Metastasis Rev., 33, 1109, 10.1007/s10555-014-9533-1 O'Flaherty, 2003, TOX defines a conserved subfamily of HMG-box proteins, BMC Genomics, 4, 13, 10.1186/1471-2164-4-13 Christopher, 1993, Solution structure of a DNA-binding domain from HMG1, Nucleic Acids Res., 21, 3427, 10.1093/nar/21.15.3427 Bewley, 1998, MINOR GROOVE-BINDING ARCHITECTURAL PROTEINS: structure, function, and DNA recognition, Annu. Rev. Biophys. Biomol. Struct., 105, 10.1146/annurev.biophys.27.1.105 Yuan, 2009, TOX3 regulates calcium-dependent transcription in neurons, Proc. Natl. Acad. Sci. U. S. A., 106, 2909, 10.1073/pnas.0805555106 Dittmer, 2011, TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex, J. Cell Sci., 252, 10.1242/jcs.068759 Bastien, 2015, IL-1alpha gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3, J. Neurosci., 35, 10715, 10.1523/JNEUROSCI.0498-15.2015 Cowper-Sal lari, 2012, Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression, Nat. Genet., 44, 1191, 10.1038/ng.2416 Jiang, 2016, The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population, Oncotarget, 7, 10.18632/oncotarget.10874 De Craene, 2013, Regulatory networks defining EMT during cancer initiation and progression, Nat. Rev. Canc., 13, 97, 10.1038/nrc3447 Brabletz, 2012, To differentiate or not — routes towards metastasis, Nat. Rev. Canc., 12, 425, 10.1038/nrc3265 Nieto, 2011, The ins and outs of the epithelial to mesenchymal transition in health and disease, Annu. Rev. Cell Dev. Biol., 27, 347, 10.1146/annurev-cellbio-092910-154036 Lamouille, 2014, Molecular mechanisms of epithelial-mesenchymal transition, Nat. Rev. Mol. Cell Biol., 15, 178, 10.1038/nrm3758 Wood, 2003, Loss of E-cadherin expression is associated with metastatic progression in human renal cell carcinoma, J. Urol., 169, 145 Ni, 2014, Downregulation of FOXO3a promotes tumor metastasis and is associated with metastasis-free survival of patients with clear cell renal cell carcinoma, Clin. Cancer Res., 20, 1779, 10.1158/1078-0432.CCR-13-1687 Knowles, 2013, Integrin alphavbeta3 and fibronectin upregulate Slug in cancer cells to promote clot invasion and metastasis, Cancer Res., 73, 6175, 10.1158/0008-5472.CAN-13-0602 Ni, 2016, Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer, Nat. Cell Biol., 18, 1221, 10.1038/ncb3425 Ju, 2017, NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression, Nat. Commun., 8, 928, 10.1038/s41467-017-00988-5 Sharili, 2013, Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development, Cancer Lett., 333, 170, 10.1016/j.canlet.2013.01.027 Kroeger, 2012, Prognostic value of microvascular invasion in predicting the cancer specific survival and risk of metastatic disease in renal cell carcinoma: a multicenter investigation, J. Urol., 187, 418, 10.1016/j.juro.2011.10.024 Beroukhim, 2009, Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney, Cancer Res., 69, 4674, 10.1158/0008-5472.CAN-09-0146 Jones, 2005, Gene signatures of progression and metastasis in renal cell cancer, Clin. Cancer Res., 11, 5730, 10.1158/1078-0432.CCR-04-2225 Yusenko, 2009, High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas, BMC Canc., 9, 152, 10.1186/1471-2407-9-152 Gumz, 2007, Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma, Clin. Cancer Res., 13, 4740, 10.1158/1078-0432.CCR-07-0143 Lenburg, 2003 Williams, 1978, In vitro cultivation of human renal cell cancer. II. Characterization of cell lines, In Vitro, 14, 779, 10.1007/BF02617972 Shan, 2013, TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness, Cancer Res., 73, 2840, 10.1158/0008-5472.CAN-12-4313 Banks, 2006, Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer, Cancer Res., 66, 2000, 10.1158/0008-5472.CAN-05-3074 Morris, 2016, The epigenetic landscape of renal cancer, Nat. Rev. Nephrol., 13, 47, 10.1038/nrneph.2016.168 Cancer, 2013, Genome Atlas Research, Comprehensive molecular characterization of clear cell renal cell carcinoma, Nature, 499, 43, 10.1038/nature12222 Kim, 2012, Rap1GAP regulates renal cell carcinoma invasion, Cancer Lett., 320, 65, 10.1016/j.canlet.2012.01.022 Kim, 2016 Liu, 2016, Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils, Cancer Cell, 30, 243, 10.1016/j.ccell.2016.06.021 Ouzounova, 2017, Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade, Nat. Commun., 8, 14979, 10.1038/ncomms14979 Yang, 2008, Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis, Cancer Cell, 13, 23, 10.1016/j.ccr.2007.12.004 Tessema, 2012, Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers, PLoS One, 7, 10.1371/journal.pone.0034850 Han, 2016, Genetic and epigenetic regulation of TOX3 expression in breast cancer, PLoS One, 11, e0165559, 10.1371/journal.pone.0165559