TOPICAL PHENYTOIN IN WOUND HEALING

International Journal of Dermatology - Tập 32 Số 3 - Trang 214-217 - 1993
ARVIND K. PENDSE1, Akhilesh Sharma1, ASHA SODANI1, SUMAN HADA1
1From the Department of Surgery, Ravindra Nath Tagore Medical College, Udaipur, Rajasthan, India.

Tóm tắt

Abstract Background. Phenytoin, introduced in 1937 as an antiseizure medication, has since been reported to promote wound healing when applied as a topical agent. This study was undertaken to evaluate its effectiveness in chronic skin ulcers. Methods. Seventy‐five inpatients with chronic skin ulcers were included in this controlled trial. Forty patients were treated with topical phenytoin, and 35 patients with conventional saline dressings. Assessment of the wounds included wound area, bacteriologic cultures, and clinical assessment by blind observers at baseline and every 7 days thereafter over the 4‐week treatment period. Results. Wound area reduction was greater in the phenytoin group than in controls. Fifty percent of phenytoin‐treated wounds had negative cultures by day 7, compared to 17% of controls. Healthy granulation tissue appeared earlier with phenytoin. At the end of the fourth week, 29 of 40 phenytoin‐treated ulcers had healed completely versus 10 of 35 controls. Conclusions. Topical phenytoin appears to be an effective, inexpensive, and widely available therapeutic agent In wound healing. Further clinical use and evaluation is merited.

Từ khóa


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Thông tin xuất bản

International Journal of Dermatology

Tập 32 Số 3

214-217

Thông tin tác giả