TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels

Neuron - Tập 111 - Trang 3195-3210.e7 - 2023
Wang Zheng1, Shaun Rawson2,3, Zhangfei Shen4, Elakkiya Tamilselvan5,6, Harper E. Smith5,6, Julia Halford7, Chen Shen8, Swetha E. Murthy7, Maximilian H. Ulbrich9,10, Marcos Sotomayor5,6, Tian-Min Fu4, Jeffrey R. Holt1
1Departments of Otolaryngology & Neurology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
2Harvard Cryo-Electron Microscopy Center for Structural Biology, Harvard Medical School, Boston, MA 02115, USA
3Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
4Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA
5Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
6Biophysics Program, The Ohio State University, Columbus, OH 43210, USA
7Vollum Institute, Oregon Health and Science University, Portland, OR 97239 USA
8Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA
9BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany
10Internal Medicine IV, University of Freiburg Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

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