THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective

Annual Review of Physical Chemistry - Tập 48 Số 1 - Trang 545-600 - 1997
José N. Onuchic1, Zaida Luthey‐Schulten2, Peter G. Wolynes2
1Department of Physics, University of California at San Diego, La Jolla, California 92093-0319
2School of Chemical Sciences, University of Illinois, Urbana, Illinois, 61801

Tóm tắt

▪ Abstract  The energy landscape theory of protein folding is a statistical description of a protein's potential surface. It assumes that folding occurs through organizing an ensemble of structures rather than through only a few uniquely defined structural intermediates. It suggests that the most realistic model of a protein is a minimally frustrated heteropolymer with a rugged funnel-like landscape biased toward the native structure. This statistical description has been developed using tools from the statistical mechanics of disordered systems, polymers, and phase transitions of finite systems. We review here its analytical background and contrast the phenomena in homopolymers, random heteropolymers, and protein-like heteropolymers that are kinetically and thermodynamically capable of folding. The connection between these statistical concepts and the results of minimalist models used in computer simulations is discussed. The review concludes with a brief discussion of how the theory helps in the interpretation of results from fast folding experiments and in the practical task of protein structure prediction.

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Annual Review of Physical Chemistry

Tập 48 Số 1

545-600

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