THE MAGIC BULLETS AND TUBERCULOSIS DRUG TARGETS

Annual Review of Pharmacology and Toxicology - Tập 45 Số 1 - Trang 529-564 - 2005
Ying Zhang1
1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

Tóm tắt

▪ Abstract  Modern chemotherapy has played a major role in our control of tuberculosis. Yet tuberculosis still remains a leading infectious disease worldwide, largely owing to persistence of tubercle bacillus and inadequacy of the current chemotherapy. The increasing emergence of drug-resistant tuberculosis along with the HIV pandemic threatens disease control and highlights both the need to understand how our current drugs work and the need to develop new and more effective drugs. This review provides a brief historical account of tuberculosis drugs, examines the problem of current chemotherapy, discusses the targets of current tuberculosis drugs, focuses on some promising new drug candidates, and proposes a range of novel drug targets for intervention. Finally, this review addresses the problem of conventional drug screens based on inhibition of replicating bacilli and the challenge to develop drugs that target nonreplicating persistent bacilli. A new generation of drugs that target persistent bacilli is needed for more effective treatment of tuberculosis.

Từ khóa


Tài liệu tham khảo

Ryan F, 1993, How the Battle against Tuberculosis Was Won and Lost, 3

2. World Health Organization. 2003. The World Health Organization Global Tuberculosis Program. http://www.who.int/gtb/

Center for Disease Control, 1993, Morb. Mortal. Wkly. Rep, 42, 427,433

Kimerling ME, 1999, Int. J. Tuberc. Lung Dis, 3, 451

De Cock KM, 1999, Int. J. Tuberc. Lung Dis, 3, 457

Tuberculosis: a global emergency, 1993, World Health Forum, 14, 438

Global Alliance for Tuberculosis Drug Development, 2001, Tuberculosis, 81, 1, 10.1054/tube.2001.0288

10.1016/j.tube.2003.08.019

10.1016/S1472-9792(02)00076-8

10.1517/13543784.11.8.1033

10.2174/1389450024605391

Barry CE, 2001, Curr. Opin. Investig. Drugs, 2, 198

Inderlied CB, 1999, Manual of Clinical Microbiology, 7, 1601

10.1055/s-0028-1129486

Hatfull G, 2000, Molecular Genetics of Mycobacteria

16. Deleted in proof

10.3181/00379727-55-14461

Rich A, 1938, Bull. Johns Hopkins Hosp, 62, 77

Hinshaw HC, 1950, Am. Rev. Tuberc, 61, 145

10.1016/S0140-6736(46)91185-3

10.1126/science.92.2383.204

Chorine V, 1945, C. R. Acad. Sci., 220, 150

Bernstein J, 1952, Am. Rev. Tuberc, 65, 357

10.1126/science.116.3006.129

10.1515/znb-1952-0805

Zhang Y, 2003, Tuberculosis, 2, 739

Malone L, 1952, Am. Rev. Tuberc, 65, 511

Liebermann D, 1956, C. R. Acad. Sci, 242, 2409

Thomas JP, 1961, Am. Rev. Respir. Dis, 83, 891

Kurosawa H, 1952, J. Antibiot. Ser. B, 5, 682

Umezawa H, 1957, J. Antibiot. Jpn. Ser. A, 10, 181

Bartz QR, 1951, Am. Rev. Tuberc, 63, 4

Herr EB, 1960, Proc. Indiana Acad. Sci, 69, 134

Sensi P, 1959, Il. Farmaco. Sci, 14, 146

Maggi N, 1966, Farmaco. Sci, 21, 68

Deitz WH, 1963, Antimicrob. Agents Chemother, 161, 583

Tsunekawa HMT, 1987, Kekkaku, 62, 435

10.1093/jac/26.2.227

Fox W, 1999, Int. J. Tuberc. Lung Dis, 3, S231

Canetti G, 1955, The Tubercle Bacillus in the Pulmonary Lesion of Man

10.2741/1291

Gomez JE, 2003, Tuberculosis, 2, 101

10.1128/IAI.69.7.4195-4201.2001

10.1378/chest.76.6.771

Zhang Y, 2003, Int. J. Tuberc. Lung Dis, 7, 6

10.2741/1289

Zhang Y, 2004, Pathogenesis of Tuberculosis, 2

10.1038/358591a0

10.1099/00221287-63-1-41

10.1126/science.8284673

10.1126/science.279.5347.98

10.1002/chem.200204637

Winder F, 1982, The Biology of Mycobacteria, 354

Winder F, 1968, Am. Rev. Respir. Dis, 97, 719

Sriprakash KS, 1969, Indian J. Biochem, 6, 49

Miesel L, 1998, J. Bacteriol, 180, 2459, 10.1128/JB.180.9.2459-2467.1998

10.1128/AAC.45.7.2157-2159.2001

10.1073/pnas.97.17.9677

Baulard AR, 2000, J. Biol. Chem, 275, 28326, 10.1074/jbc.M003744200

10.1074/jbc.M110751200

10.1128/AAC.47.12.3799-3805.2003

10.1128/AAC.33.9.1493

10.1128/AAC.39.11.2484

Wolucka BA, 1994, J. Biol. Chem, 269, 23328, 10.1016/S0021-9258(17)31657-5

10.1038/nm0597-567

10.1073/pnas.93.21.11919

10.1128/AAC.41.8.1677

David HL, 1969, Am. Rev. Respir. Dis, 100, 579

10.1111/j.1574-6968.2001.tb10547.x

10.1128/jb.179.16.5046-5055.1997

10.1128/AAC.46.2.47-54.2002

10.1128/JB.182.23.6854-6856.2000

10.1128/AAC.47.1.283-291.2003

10.1016/0041-3879(85)90040-6

10.1016/0140-6736(93)90417-F

10.2165/00003495-199856040-00008

10.1128/AAC.42.7.1853

10.1093/jac/dkg212

10.2165/00003495-199958002-00004

Grimaldo ER, 2001, Int. J. Tuberc. Lung Dis, 5, 546

Tuberculosis Research Centre C, 2002, Indian J. Tuberc, 49, 27

10.1128/AAC.38.4.773

10.1128/AAC.40.8.1768

10.1038/192633a0

Davies J, 1965, Mol. Pharmacol, 1, 93

10.1038/185022a0

10.1073/pnas.71.10.3814

10.1111/j.1365-2958.1993.tb01253.x

Zhang Y, 2000, Mycobacterium tuberculosis, 235

10.1128/AAC.42.5.1295

Suzuki Y, 1998, J. Clin. Microbiol, 36, 1220, 10.1128/JCM.36.5.1220-1225.1998

10.1128/jb.179.15.4795-4801.1997

10.1128/AAC.47.9.2971-2973.2003

10.1038/nm0696-662

10.1128/AAC.41.3.540

Tarshis MS, 1953, Am. Rev. Tuberc, 67, 391

McDermott W, 1954, Am. Rev. Tuberc, 70, 748

10.1099/0022-1317-51-1-42

10.1099/jmm.0.45639-0

Zhang Y, 1999, J. Bacteriol, 181, 2044, 10.1128/JB.181.7.2044-2049.1999

10.1093/jac/dkg446

10.1016/j.phytochem.2004.02.013

10.1128/AAC.46.4.1022-1025.2002

10.1046/j.1365-2958.2003.03384.x

10.1128/AAC.42.8.2066

10.1128/AAC.43.1.85

10.1128/AAC.47.2.653-657.2003

10.1164/rccm.200310-1380OC

10.1128/AAC.36.3.548

10.1164/ajrccm.164.7.16471

10.1128/AAC.48.3.780-782.2004

10.1179/joc.2003.15.1.66

10.1128/AAC.39.10.2295

10.1086/313876

10.1093/jac/35.2.345

10.1128/AAC.40.11.2655

10.1128/AAC.45.7.1972-1976.2001

Barrett J, 2000, Curr. Opin. Investig. Drugs, 1, 181

10.1021/jm950956y

Oxazolidinones, a new class of synthetic antituberculosis agent, Diagn. Microbiol. Infect. Dis, 14, 465

10.1128/AAC.40.4.839

10.1128/AAC.43.5.1189

10.1016/j.bmcl.2004.01.010

10.1054/tuld.1999.0212

10.1038/31159

10.1093/oxfordjournals.jbchem.a022167

10.1016/S0006-2952(01)00571-8

10.1099/00221287-148-10-2937

10.1073/pnas.96.16.8937

10.1074/jbc.M209928200

10.1093/jac/46.6.917

Wayne LG, 1966, Scand. J. Respir. Dis, 47, 18

10.1038/1791013a0

10.1093/jac/43.5.615

10.1093/jac/44.2.209

10.1093/jac/dkh215

10.1128/AAC.43.7.1638

10.1159/000007255

10.1093/jac/47.5.505

Salih FA, 1991, Indian J. Biochem. Biophys, 28, 491

10.1128/AAC.47.3.917-922.2003

10.1093/jac/38.6.1049

10.1179/joc.1999.11.3.203

10.1159/000239036

10.1038/35016103

10.1128/AAC.37.2.183

10.1016/0223-5234(89)90034-2

10.1046/j.1365-2958.2000.01908.x

10.1093/jac/dkh184

10.1093/jac/dkh054

Waller AS, 2002, Curr. Opin. Drug Discov. Dev, 5, 785

10.1128/AAC.48.1.80-85.2004

10.1093/jac/dkh129

10.1046/j.1365-2672.92.5s1.13.x

10.1054/tuld.2000.0240

10.1073/pnas.121172498

10.1046/j.1365-2958.2003.03474.x

10.1128/JB.184.24.6760-6767.2002

10.1084/jem.20030205

Cashel M, 1996, Escherichia coli and Salmonella: Cellular and Molecular Biology, 1488

10.1128/JB.182.17.4889-4898.2000

10.1073/pnas.1631248100

10.1038/35021074

Wayne LG, 1982, Infect. Immun, 37, 1042, 10.1128/iai.37.3.1042-1049.1982

10.1073/pnas.96.20.11554

10.1128/IAI.70.11.6330-6338.2002

10.1038/77964

10.1016/S1097-2765(00)80250-6

10.1073/pnas.94.20.10961

10.1073/pnas.94.20.10955

10.1016/0076-6879(91)04027-L

10.1073/pnas.1231432100

10.1073/pnas.231275498

10.1046/j.1365-2958.2003.03425.x

10.1128/JB.186.4.895-902.2004

10.1016/0378-1119(95)00427-8

10.1111/j.1365-2958.2003.03922.x

10.1111/j.1365-2958.2003.03958.x

10.1128/jb.179.9.2922-2929.1997

10.1128/JB.183.20.6119-6125.2001

10.1046/j.1365-2958.2001.02525.x

10.1128/IAI.71.12.7170-7172.2003

10.1128/IAI.72.5.3038-3041.2004

10.1073/pnas.93.7.2790

10.1128/IAI.68.10.5575-5580.2000

10.1517/13543784.11.8.1149

10.1128/CMR.16.3.463-496.2003

10.1073/pnas.2134250100

10.1016/S1369-5274(00)00070-9

10.1021/jm9803572

10.1517/13543784.9.10.2351

10.1073/pnas.95.9.5317

10.1016/S0960-894X(01)00024-5

10.2174/0929867043455765

10.1016/S0960-894X(98)00325-4

196. Deleted in proof

10.1128/jb.178.11.3314-3321.1996

10.1046/j.1365-2958.1997.6361999.x

10.1099/mic.0.26516-0

10.1073/pnas.221272198

10.1046/j.1365-2958.2001.02500.x

10.1099/mic.0.26245-0

10.1016/j.bbrc.2003.12.082

10.1054/tuld.2000.0240

10.1016/S0378-1097(04)00002-3

10.1128/AAC.40.12.2813

10.1074/jbc.M000569200

10.1099/00221287-148-10-3101

10.1042/bj20011628

10.1093/jac/43.2.219

10.1128/AAC.45.4.1143-1150.2001

10.2741/1293

10.1093/jac/dkg287

10.1111/j.1365-2958.1995.mmi_17050889.x

10.1073/pnas.92.14.6625

10.1126/science.7542800

10.2174/1381612023394782

10.1016/S0163-7258(02)00222-X

10.2174/1568005023342326

10.2174/1381612023394845

Cole S, 2002, Eur. Respir. J, 36, 78s–86

10.1126/science.270.5235.467

10.1126/science.7618105

10.1128/jb.178.1.273-279.1996

10.1073/pnas.96.22.12833

10.1128/AAC.47.9.2903-2913.2003

10.1046/j.1365-2958.2002.02779.x

10.2174/1568005023342551

Crabb C, 2002, Bull. World Health Organ, 80, 518

10.1128/AAC.45.7.1943-1946.2001

10.1021/cc020071p

10.1128/AAC.47.12.3682-3687.2003

10.1016/S1471-4892(02)00197-2

10.1016/j.mib.2003.08.003

McDermott W, 1958, Yale J. Biol. Med, 30, 257

Thông tin
Thông tin xuất bản

Annual Review of Pharmacology and Toxicology

Tập 45 Số 1

529-564

Thông tin tác giả