K. B. Roberts1, H. W. Florey1, Wolfgang K. Joklik1
1The Sir William Dunn School of Pathology, Oxford
Tóm tắt
1. The influence of large doses of cortisone on the mitotic activity which normally occurs after partial hepatectomy in mice was studied. At the same time the changes in liver protein, fat, glycogen and nucleic acids were followed.2. In the mice given cortisone, mitoses were rarely seen 2 days after operation, whereas at that time the mitotic rate in controls was very high. Later, at 6 days, this difference was not observed.3. Although the increase in weight of the liver after partial hepatectomy was the same in experimental and control mice, in the former this was largely due to a deposition of fat and glycogen. There was, however, some new formation of protein in cortisone‐treated mice.4. RNA regeneration was nearly normal; DNA, however, failed to regenerate in mice given cortisone.5. Cell division occurring normally in the endothelium of the crypts of Lieberkühn was not inhibited by cortisone in large doses.6. Mitoses were seen in lymphoid follicles in mice receiving large doses of cortisone.7. The conclusion that cortisone does not inhibit mitoses in every tissue is discussed.
