THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

Annual Review of Pharmacology and Toxicology - Tập 37 Số 1 - Trang 517-554 - 1997
Mahin D. Maines1
1Departments of Biophysics and Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642

Tóm tắt

▪ Abstract  The heme oxygenase (HO) system consists of two forms identified to date: the oxidative stress–inducible protein HO-1 (HSP32) and the constitutive isozyme HO-2. These proteins, which are different gene products, have little in common in primary structure, regulation, or tissue distribution. Both, however, catalyze oxidation of heme to biologically active molecules: iron, a gene regulator; biliverdin, an antioxidant; and carbon monoxide, a heme ligand. Finding the impressive heme-degrading activity of brain led to the suggestion that “HO in brain has functions aside from heme degradation” and to subsequent exploration of carbon monoxide as a promising and potentially significant messenger molecule. There is much parallelism between the biological actions and functions of the CO- and NO-generating systems; and their regulation is intimately linked. This review highlights the current information on molecular and biochemical properties of HO-1 and HO-2 and addresses the possible mechanisms for mutual regulatory interactions between the CO- and NO-generating systems.

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Annual Review of Pharmacology and Toxicology

Tập 37 Số 1

517-554

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