TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors
Tóm tắt
Từ khóa
Tài liệu tham khảo
Taylor, 2001, CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade, J Exp Med, 193, 1311, 10.1084/jem.193.11.1311
Cohen, 2002, CD4 (+) CD25 (+) immunoregulatory T cells: new therapeutics for graft-versus-host disease, J Exp Med, 196, 401, 10.1084/jem.20020090
Sakaguchi, 1995, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases., J Immunol, 155, 1151, 10.4049/jimmunol.155.3.1151
Dieckmann, 2001, Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood, J Exp Med, 193, 1303, 10.1084/jem.193.11.1303
Levings, 2001, Human CD4+CD25+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function, J Exp Med, 193, 1295, 10.1084/jem.193.11.1295
Jonuleit, 2001, Identification and functional characterization of human CD4 (+) CD25 (+) T cells with regulatory properties isolated from peripheral blood, J Exp Med, 193, 1285, 10.1084/jem.193.11.1285
Thornton, 2000, Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific, J Immunol, 164, 183, 10.4049/jimmunol.164.1.183
Fu, 2004, CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential. Am, J Transplant, 4, 65
Walker, 2003, Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo, J Exp Med, 198, 249, 10.1084/jem.20030315
Wahl, 1994, Transforming growth factor beta: the good, the bad, and the ugly, J Exp Med, 180, 1587, 10.1084/jem.180.5.1587
Massague, 1996, TGF-beta signaling. Receptors, transducers, and Mad proteins, Cell, 85, 947, 10.1016/S0092-8674(00)81296-9
Massague, 2000, Transcriptional control by the TGF-beta/Smad signaling system, EMBO J, 19, 1745, 10.1093/emboj/19.8.1745
Gorelik, 2002, Transforming growth factor-beta in T-cell biology, Nat Rev Immunol, 2, 46, 10.1038/nri704
Tiemessen, 2003, Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response, Int Immunol, 15, 1495, 10.1093/intimm/dxg147
Weiner, 2001, Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells, Immunol Rev, 182, 207, 10.1034/j.1600-065X.2001.1820117.x
Levings, 2002, The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells, Int Arch Allergy Immunol, 129, 263, 10.1159/000067596
Horwitz, 2003, The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets, J Leukoc Biol, 74, 471, 10.1189/jlb.0503228
Yamagiwa, 2001, A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood, J Immunol, 166, 7282, 10.4049/jimmunol.166.12.7282
Zheng, 2002, Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors, J Immunol, 169, 4183, 10.4049/jimmunol.169.8.4183
Chen, 2003, IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function, Blood, 101, 5076, 10.1182/blood-2002-09-2798
Brunkow, 2001, Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse, Nat Genet, 27, 68, 10.1038/83784
Wildin, 2001, X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy, Nat Genet, 27, 18, 10.1038/83707
Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490
Fontenot, 2003, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat Immunol, 4, 330, 10.1038/ni904
Khattri, 2003, An essential role for Scurfin in CD4+CD25+ T regulatory cells, Nat Immunol, 4, 337, 10.1038/ni909
Seder, 1992, The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice, J Exp Med, 176, 1091, 10.1084/jem.176.4.1091
Zhang, 2003, Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets, Am J Transplant, 3, 1230, 10.1046/j.1600-6143.2003.00215.x
Massague, 1992, Transforming growth factor-beta, Cancer Surv, 12, 81
Lopez-Candales, 1996, Different temporal and spatial distribution of TGF-beta 1 and TGF-beta 2 in rabbit vascular tissue: potential role in normal vessel growth and maturation, Cytokine, 8, 675, 10.1006/cyto.1996.0090
Nakamura, 2001, Cell contact-dependent immunosuppression by CD4 (+) CD25 (+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta, J Exp Med, 194, 629, 10.1084/jem.194.5.629
Massague, 1990, The transforming growth factor-beta family, Annu Rev Cell Biol, 6, 597, 10.1146/annurev.cb.06.110190.003121
Siegel, 2003, Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer, Nat Rev Cancer, 3, 807, 10.1038/nrc1208
Dybedal, 1997, Transforming growth factor-beta1 abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells, Blood, 90, 3395, 10.1182/blood.V90.9.3395
Chipuk, 2001, Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells, J Biol Chem, 276, 26614, 10.1074/jbc.M100913200
Gorelik, 2002, Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation, J Exp Med, 195, 1499, 10.1084/jem.20012076
Heath, 2000, TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur, J Immunol, 30, 2639
Maloy, 2003, CD4+CD25+ T (R) cells suppress innate immune pathology through cytokine-dependent mechanisms, J Exp Med, 197, 111, 10.1084/jem.20021345
Grundstrom, 2003, Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo, J Immunol, 170, 5008, 10.4049/jimmunol.170.10.5008
Caramalho, 2003, Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide, J Exp Med, 197, 403, 10.1084/jem.20021633
Montagnoli, 2002, B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans, J Immunol, 169, 6298, 10.4049/jimmunol.169.11.6298
Chen, 2003, Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-{beta} induction of transcription factor Foxp3, J Exp Med, 198, 1875, 10.1084/jem.20030152
Gavin, 2003, Control of immune homeostasis by naturally arising regulatory CD4+ T cells, Curr Opin Immunol, 15, 690, 10.1016/j.coi.2003.09.011
Kingsley, 1994, The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms, Genes Dev, 8, 133, 10.1101/gad.8.2.133
Madisen, 1988, Transforming growth factor-beta 2: cDNA cloning and sequence analysis, DNA, 7, 1, 10.1089/dna.1988.7.1
Segarini, 1987, Membrane binding characteristics of two forms of transforming growth factor-beta, J Biol Chem, 262, 14655, 10.1016/S0021-9258(18)47846-5
Salomon, 2000, B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes, Immunity, 12, 431, 10.1016/S1074-7613(00)80195-8
Liu, 2001, B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis, J Immunol, 167, 1830, 10.4049/jimmunol.167.3.1830
Takahashi, 2000, Immunologic self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4, J Exp Med, 192, 303, 10.1084/jem.192.2.303
Takahashi, 1998, Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state, Int Immunol, 10, 1969, 10.1093/intimm/10.12.1969