T-sing progenitors to commit

Scollay, 1985, Identification of early stages of T lymphocyte development in the thymus cortex and medulla, J. Immunol., 134, 3632, 10.4049/jimmunol.134.6.3632 Scollay, 1991, T-cell subset relationships in thymocyte development, Curr. Opin. Immunol., 3, 204, 10.1016/0952-7915(91)90051-2 Vanhecke, 1997, Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation, J. Immunol., 159, 5973, 10.4049/jimmunol.159.12.5973 Blom, 1999, TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation, Blood, 93, 3033, 10.1182/blood.V93.9.3033 Weerkamp, 2005, Age-related changes in the cellular composition of the thymus in children, J. Allergy Clin. Immunol., 115, 834, 10.1016/j.jaci.2004.10.031 Rothenberg, 2002, Lineage plasticity and commitment in T-cell development, Immunol. Rev., 187, 96, 10.1034/j.1600-065X.2002.18709.x Radtke, 2004, Notch regulation of lymphocyte development and function, Nat. Immunol., 5, 247, 10.1038/ni1045 Collins, 2005, Selection and lineage specification in the thymus: commitment 4-stalled, Immunity, 23, 4, 10.1016/j.immuni.2005.07.003 Garcia-Ojeda, 2005, Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus, J. Immunol., 175, 4363, 10.4049/jimmunol.175.7.4363 Rodewald, 1994, Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization, EMBO J., 13, 4229, 10.1002/j.1460-2075.1994.tb06743.x Peault, 1996, Hematopoietic stem cell emergence in embryonic life: developmental hematology revisited, J. Hematother., 5, 369, 10.1089/scd.1.1996.5.369 Carlyle, 1998, Requirement for the thymus in alphabeta T lymphocyte lineage commitment, Immunity, 9, 187, 10.1016/S1074-7613(00)80601-9 Douagi, 2000, Characterization of T cell precursor activity in the murine fetal thymus: evidence for an input of T cell precursors between days 12 and 14 of gestation, Eur. J. Immunol., 30, 2201, 10.1002/1521-4141(2000)30:18<2201::AID-IMMU2201>3.0.CO;2-J Masuda, 2005, Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors, EMBO J., 24, 4052, 10.1038/sj.emboj.7600878 Harman, B.C. et al. (2005) B lineage choice occurs prior to intrathymic notch signalling. Blood Benz, 2005, A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision, J. Exp. Med., 202, 21, 10.1084/jem.20050146 Sambandam, 2005, Notch signaling controls the generation and differentiation of early T lineage progenitors, Nat. Immunol., 6, 663, 10.1038/ni1216 Porritt, 2004, Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages, Immunity, 20, 735, 10.1016/j.immuni.2004.05.004 Balciunaite, 2005, The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential, Blood, 105, 1930, 10.1182/blood-2004-08-3087 Gounari, 2002, Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene, Nat. Immunol., 3, 489, 10.1038/ni778 Igarashi, 2002, Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow, Immunity, 17, 117, 10.1016/S1074-7613(02)00366-7 Petrie, 2005, Many roads, one destination for T cell progenitors, J. Exp. Med., 202, 11, 10.1084/jem.20050990 Adolfsson, 2001, Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity, Immunity, 15, 659, 10.1016/S1074-7613(01)00220-5 Adolfsson, 2005, Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment, Cell, 121, 295, 10.1016/j.cell.2005.02.013 Wiesmann, 2000, Expression of CD27 on murine hematopoietic stem and progenitor cells, Immunity, 12, 193, 10.1016/S1074-7613(00)80172-7 Bhandoola, 2003, Early T lineage progenitors: new insights, but old questions remain, J. Immunol., 171, 5653, 10.4049/jimmunol.171.11.5653 Kondo, 1997, Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, 91, 661, 10.1016/S0092-8674(00)80453-5 Allman, 2003, Thymopoiesis independent of common lymphoid progenitors, Nat. Immunol., 4, 168, 10.1038/ni878 Borghesi, 2004, B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors, J. Exp. Med., 199, 491, 10.1084/jem.20031800 Kawamoto, 1999, Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver, J. Immunol., 162, 2725, 10.4049/jimmunol.162.5.2725 Ohmura, 1999, Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse, J. Immunol., 163, 4788, 10.4049/jimmunol.163.9.4788 Ikawa, 1999, Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay, J. Exp. Med., 190, 1617, 10.1084/jem.190.11.1617 Udomsakdi, 1992, Characterization of primitive hematopoietic cells in normal human peripheral blood, Blood, 80, 2513, 10.1182/blood.V80.10.2513.2513 Wright, 2001, Physiological migration of hematopoietic stem and progenitor cells, Science, 294, 1933, 10.1126/science.1064081 Weerkamp, F. et al. (2005) The human thymus contains multipotent progenitors with T/B-lymphoid, myeloid and erythroid lineage potential. Blood DOI 10.1182/blood-2005-08-3412 (http://www.bloodjournal.org) Wu, 1991, CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus, Nature, 349, 71, 10.1038/349071a0 Tan, 2005, Requirement for Notch1 signals at sequential early stages of intrathymic T cell development, Nat. Immunol., 6, 671, 10.1038/ni1217 Lu, 2005, The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRbeta chains than fetal progenitors, J. Immunol., 175, 5848, 10.4049/jimmunol.175.9.5848 Matsuzaki, 1993, Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation, J. Exp. Med., 178, 1283, 10.1084/jem.178.4.1283 Wilson, 2001, Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus, J. Exp. Med., 194, 1003, 10.1084/jem.194.7.1003 Pui, 1999, Notch1 expression in early lymphopoiesis influences B versus T lineage determination, Immunity, 11, 299, 10.1016/S1074-7613(00)80105-3 De Smedt, 2002, Active form of Notch imposes T cell fate in human progenitor cells, J. Immunol., 169, 3021, 10.4049/jimmunol.169.6.3021 Artavanis-Tsakonas, 1999, Notch signaling: cell fate control and signal integration in development, Science, 284, 770, 10.1126/science.284.5415.770 de La Coste, 2005, In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects, J. Immunol., 174, 2730, 10.4049/jimmunol.174.5.2730 Kawamata, 2002, Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations, Oncogene, 21, 3855, 10.1038/sj.onc.1205487 Tomita, 1999, The bHLH gene Hes1 is essential for expansion of early T cell precursors, Genes Dev., 13, 1203, 10.1101/gad.13.9.1203 Hoebeke, I. et al. (2005) Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells. Blood Taghon, 2005, Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling, Genes Dev., 19, 965, 10.1101/gad.1298305 Ciofani, 2005, Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism, Nat. Immunol., 6, 881, 10.1038/ni1234 Koch, 2001, Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1, Immunity, 15, 225, 10.1016/S1074-7613(01)00189-3 Lepault, 1981, An in vivo assay for thymus-homing bone marrow cells, Nature, 293, 151, 10.1038/293151a0 Dik, 2005, New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling, J. Exp. Med., 201, 1715, 10.1084/jem.20042524 Staal, 2003, Wnt signaling in the thymus, Curr. Opin. Immunol., 15, 204, 10.1016/S0952-7915(03)00003-7 Staal, 2005, WNT signalling and haematopoiesis: a WNT-WNT situation, Nat. Rev. Immunol., 5, 21, 10.1038/nri1529 Okamura, 1998, Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1, Immunity, 8, 11, 10.1016/S1074-7613(00)80454-9 Schilham, 1998, Critical involvement of Tcf-1 in expansion of thymocytes, J. Immunol., 161, 3984, 10.4049/jimmunol.161.8.3984 Staal, 2004, Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion, J. Immunol., 172, 1099, 10.4049/jimmunol.172.2.1099 Staal, 2001, Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription, Eur. J. Immunol., 31, 285, 10.1002/1521-4141(200101)31:1<285::AID-IMMU285>3.0.CO;2-D Staal, 2001, Transcriptional control of T lymphocyte differentiation, Stem Cells, 19, 165, 10.1634/stemcells.19-3-165 Hardy, 2003, B-cell commitment: deciding on the players, Curr. Opin. Immunol., 15, 158, 10.1016/S0952-7915(03)00012-8 Nutt, 1999, Commitment to the B-lymphoid lineage depends on the transcription factor Pax5, Nature, 401, 556, 10.1038/44076 Urbanek, 1994, Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP, Cell, 79, 901, 10.1016/0092-8674(94)90079-5 Souabni, 2002, Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1, Immunity, 17, 781, 10.1016/S1074-7613(02)00472-7 Radtke, 1999, Deficient T cell fate specification in mice with an induced inactivation of Notch1, Immunity, 10, 547, 10.1016/S1074-7613(00)80054-0 Schroeder, 2003, Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression, J. Immunol., 170, 5538, 10.4049/jimmunol.170.11.5538 Lam, 2000, Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by notch-1, J. Biol. Chem., 275, 19676, 10.1074/jbc.M002866200 Schmitt, 2002, Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro, Immunity, 17, 749, 10.1016/S1074-7613(02)00474-0 Schmitt, 2004, Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro, Nat. Immunol., 5, 410, 10.1038/ni1055 Watowich, 1996, Cytokine receptor signal transduction and the control of hematopoietic cell development, Annu. Rev. Cell Dev. Biol., 12, 91, 10.1146/annurev.cellbio.12.1.91 Balciunaite, 2005, B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential, Eur. J. Immunol., 35, 2019, 10.1002/eji.200526318 de La Coste, 2006, Notch signaling: Distinct ligands induce specific signals during lymphocyte development and maturation, Immunol. Lett., 102, 1, 10.1016/j.imlet.2005.06.014 Boyd, 1993, The thymic microenvironment, Immunol. Today, 14, 445, 10.1016/0167-5699(93)90248-J Witt, 2005, Directed migration of positively selected thymocytes visualized in real time, PLoS Biol., 3, e160, 10.1371/journal.pbio.0030160