T cell tolerance to the skin: a central role for central tolerance

Springer Science and Business Media LLC - Tập 29 - Trang 59-64 - 2007
Prisca Schuler1, Emmanuel Contassot1, Bertrand Huard1
1Louis Jeantet Skin Cancer Laboratory, Department of Patho-Immunology, University Medical Center, Geneva 4, Switzerland

Tóm tắt

T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs. One may ask why two mechanisms are needed to insure T cell tolerance. These two mechanisms share redundant functions and dysfunctions, leading to T cell-mediated autoimmune syndromes. By reviewing the literature on relevant animal models for T cell tolerance and our own recent findings, we are providing evidences that only central tolerance is acting for the skin.

Tài liệu tham khảo

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