T-cell receptor signal transmission: who gives an ITAM?

Samelson, 2002, Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins, Annu. Rev. Immunol., 20, 371, 10.1146/annurev.immunol.20.092601.111357

Veillette, 2002, Negative regulation of immunoreceptor signaling, Annu. Rev. Immunol., 20, 669, 10.1146/annurev.immunol.20.081501.130710

Bu, 1995, Analysis of the interaction of ZAP-70 and Syk protein tyrosine kinases with the T cell antigen receptor by plasmon resonance, Proc. Natl. Acad. Sci. U. S. A., 92, 5106, 10.1073/pnas.92.11.5106

Iwashima, 1994, Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases, Science, 263, 1136, 10.1126/science.7509083

Chan, 1995, Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function, EMBO J., 14, 2499, 10.1002/j.1460-2075.1995.tb07247.x

Jordan, 2003, Adaptors as central mediators of transduction in immune cells, Nat. Immunol., 4, 110, 10.1038/ni0203-110

Weiss, 1993, T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases, Cell, 73, 209, 10.1016/0092-8674(93)90221-B

Love, 2000, ITAM multiplicity and thymocyte selection: how long can you go, Immunity, 12, 591, 10.1016/S1074-7613(00)80210-1

Alarcon, 2003, Initiation of TCR signaling: regulation within CD3 dimers, Immunol. Rev., 191, 38, 10.1034/j.1600-065X.2003.00017.x

Lanier, 1998, Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells, Nature, 391, 703, 10.1038/35642

Willems, 1995, The YXXL signalling motifs of the bovine leukemia virus transmembrane protein are required for in vivo infection and maintenance of high viral loads, J. Virol., 69, 4137, 10.1128/JVI.69.7.4137-4141.1995

Miller, 1994, An integral membrane protein (LMP2) blocks reactivation of Epstein–Barr virus from latency following surface immunoglobulin crosslinking, Proc. Natl. Acad. Sci. U. S. A., 91, 772, 10.1073/pnas.91.2.772

Lagunoff, 1999, Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus, Proc. Natl. Acad. Sci. U. S. A., 96, 5704, 10.1073/pnas.96.10.5704

Du, 1995, Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys, Cell, 82, 665, 10.1016/0092-8674(95)90038-1

Geimonen, 2003, Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements, J. Virol., 77, 1638, 10.1128/JVI.77.2.1638-1643.2003

Dykstra, 2001, Epstein–Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR, Immunity, 14, 57, 10.1016/S1074-7613(01)00089-9

Irving, 1991, The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways, Cell, 64, 891, 10.1016/0092-8674(91)90314-O

Romeo, 1991, Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides, Cell, 64, 1037, 10.1016/0092-8674(91)90327-U

Letourneur, 1992, Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3ε, Science, 255, 79, 10.1126/science.1532456

Romeo, 1992, Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor ζ chain, Cell, 68, 889, 10.1016/0092-8674(92)90032-8

Irving, 1993, Functional characterization of a signal transducing motif present in the T cell receptor ζ chain, J. Exp. Med., 177, 1093, 10.1084/jem.177.4.1093

Weissenhorn, 1996, Phosphorylated T cell receptor ζ-chain and ZAP-70 tandem SH2 domains form a 1:3 complex in vitro, Eur. J. Immunol., 238, 440

Shinkai, 1995, CD3ε and CD3ζ cytoplasmic domains can independently generate signals for T cell development and function, Immunity, 2, 401, 10.1016/1074-7613(95)90148-5

Latour, 1997, Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase, Mol. Cell. Biol., 17, 4434, 10.1128/MCB.17.8.4434

Futterer, 1998, Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide, J. Mol. Biol., 281, 523, 10.1006/jmbi.1998.1964

Ravichandran, 1993, Interaction of Shc with the z chain of the T cells receptor upon T cell activation, Science, 262, 902, 10.1126/science.8235613

Osman, 1996, The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor ζ subunits and the CD3 γ, δ, and ε chains, Eur. J. Immunol., 26, 1063, 10.1002/eji.1830260516

Pandey, 2002, A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling, J. Biol. Chem., 277, 19131, 10.1074/jbc.M110318200

Kirchgessner, 2001, The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR ζ chain, J. Exp. Med., 193, 1269, 10.1084/jem.193.11.1269

Chikuma, 2003, Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4, J. Exp. Med., 197, 129, 10.1084/jem.20021646

Cen, 2003, Identification of UNC119 as a novel activator of SRC-type tyrosine kinases, J. Biol. Chem., 278, 8837, 10.1074/jbc.M208261200

Gorska, 2003, Unc119, a novel activator of Lck and Fyn, is essential for T cell receptor signal generation, FASEB J., 17, C221

Caplan, 1995, Cell-surface-expressed T-cell antigen receptor ζ chain is associated with the cytoskeleton, Proc. Natl. Acad. Sci. U. S. A., 92, 4768, 10.1073/pnas.92.11.4768

Yamazaki, 1999, CAST, a novel CD3ε-binding protein transducing activation signal for interleukin-2 production in T cells, J. Biol. Chem., 274, 18173, 10.1074/jbc.274.26.18173

Gil, 2002, Recruitment of Nck by CD3ε reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation, Cell, 109, 901, 10.1016/S0092-8674(02)00799-7

Pitcher, 2003, The formation and functions of the 21 and 23kDa tyrosine phosphorylated TCR ζ subunits, Immunol. Rev., 191, 47, 10.1034/j.1600-065X.2003.00003.x

van Oers, 1994, ZAP-70 is constitutively associated with tyrosine phosphorylated TCR ζ in murine thymocytes and lymph node T cells, Immunity, 1, 675, 10.1016/1074-7613(94)90038-8

Witherden, 2000, Tetracycline-controllable selection of CD4+ T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules, J. Exp. Med., 191, 355, 10.1084/jem.191.2.355

Jameson, 1995, T cell receptor antagonists and partial agonists, Immunity, 2, 1, 10.1016/1074-7613(95)90074-8

Straus, 1993, The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation, J. Exp. Med., 178, 1523, 10.1084/jem.178.5.1523

Werlen, 2000, A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity, Nature, 406, 422, 10.1038/35019094

Delgado, 2000, CD3 δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection, Nature, 406, 426, 10.1038/35019102

Haks, 2002, Contributions of the T cell receptor-associated CD3γ-ITAM to thymocyte selection, J. Exp. Med., 196, 1, 10.1084/jem.20020268

Shores, 1997, Role of multiple TCR ζ chain signaling motifs in selection of the T cell repertoire, J. Exp. Med., 185, 893, 10.1084/jem.185.5.893

Dave, 1997, CD3 δ deficiency arrests development of the α-β but not the γ-δ T cell lineage, EMBO J., 16, 1360, 10.1093/emboj/16.6.1360

Sommers, 2000, Function of CD3ε-mediated signals in T cell development, J. Exp. Med., 192, 913, 10.1084/jem.192.6.913

Wegener, 1992, The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules, Cell, 68, 83, 10.1016/0092-8674(92)90208-T

van Oers, 1998, Regulation of T cell receptor signal transduction in murine thymocytes by multiple TCR ζ-chain signaling motifs, J. Immunol., 160, 163, 10.4049/jimmunol.160.1.163

Ardouin, 1999, Crippling of CD3-ζ ITAMs does not impair T cell receptor signaling, Immunity, 10, 409, 10.1016/S1074-7613(00)80041-2

van Oers, 2000, The 21 and 23kDa forms of TCR ζ are generated by specific ITAM phosphorylations, Nat. Immunol., 1, 322, 10.1038/79774

Love, 2000, Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection, J. Immunol., 165, 3080, 10.4049/jimmunol.165.6.3080

Sloan-Lancaster, 1994, Partial T cell signaling: altered phospho-ζ and lack of ZAP-70 recruitment in APL-induced T cell anergy, Cell, 79, 913, 10.1016/0092-8674(94)90080-9

Madrenas, 1995, ζ phosphorylation without ZAP-70 activation induced by T cell receptor antagonists or partial agonists, Science, 267, 515, 10.1126/science.7824949

Smyth, 1998, Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes, Proc. Natl. Acad. Sci. U. S. A., 95, 8193, 10.1073/pnas.95.14.8193

Liu, 1999, Differential CD3 ζ phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands, J. Immunol., 163, 599, 10.4049/jimmunol.163.2.599

Pitcher, 2003, T cell antagonism is functionally uncoupled from the 21 and 23kDa tyrosine-phosphorylated TCR ζ subunits, J. Immunol., 171, 845, 10.4049/jimmunol.171.2.845

Hatada, 1995, Molecular basis for the interactions of the protein tyrosine kinase ZAP-70 with the T cell receptor, Nature, 377, 32, 10.1038/377032a0

Timson-Gauen, 1992, p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain, Mol. Cell. Biol., 12, 5438, 10.1128/MCB.12.12.5438