T cell mediated pathogenesis in EAE: Molecular mechanisms
Tóm tắt
Từ khóa
Tài liệu tham khảo
Rivers, 1933, J Exp Med, Observations on attempts to produce acute encephalomyelitis in monkeys, 39
Ben-Nun, 1981, Eur J Immunol, The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis, 195
Zamvil, 1986, Nature, T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis, 258
Ben-Nun, 1981, Nature, Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein, 60
Zamvil, 1985, Nature, T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination, 355
Serafini, 2013, Brain, Radioactive in situ hybridization for Epstein-Barr virus-encoded small RNA supports presence of Epstein-Barr virus in the multiple sclerosis brain, e233
Serafini, 2007, J Exp Med, Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain, 2899
Kurschus, 2011, Adv Immunol, Modeling a complex disease: Multiple sclerosis, 111
Barnett, 2004, Ann Neurol, Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion, 458
Lucchinetti, 1996, Brain Pathol, Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis, 259
Lucchinetti, 2000, Ann Neurol, Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination, 707
Barnett, 2006, Curr Opin Neurol, The pathology of multiple sclerosis: A paradigm shift, 242
Babbe, 2000, J Exp Med, Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction, 393
Wucherpfennig, 1992, J Exp Med, T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions, 993
Koh, 1992, Science, Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice, 1210
Ransohoff, 2012, J Clin Invest, Innate immunity in the central nervous system, 1164
Gonzalez-Navajas, 2010, J Clin Invest, TLR4 signaling in effector CD4+T cells regulates TCR activation and experimental colitis in mice, 570
Reynolds, 2010, Immunity, Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease, 692
Stromnes, 2008, Nat Med, Differential regulation of central nervous system autoimmunity by T (H) 1 and T (H) 17 cells, 337
Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
Renno, 1994, Int Immunol, Selective enrichment of Th1 CD45RBlow CD4+T cells in autoimmune infiltrates in experimental allergic encephalomyelitis, 347
Ando, 1989, Cell Immunol, Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype, 132
Lafaille, 1997, J Exp Med, Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease, 307
Ferber, 1996, J Immunol, Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE), 5
Willenborg, 1999, J Immunol, IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: A possible role for nitric oxide, 5278
Becher, 2002, J Clin Invest, Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12, 493
Gran, 2002, J Immunol, IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination, 7104
Zhang, 2003, J Immunol, Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system, 2153
Cua, 2003, Nature, Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain, 744
Langrish, 2005, J Exp Med, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, 233
Becher, 2003, J Clin Invest, IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis, 1186
Ivanov, 2006, Cell, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+T helper cells, 1121
Yang, 2008, Immunity, T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma, 29
Kurschus, 2010, Eur J Immunol, Genetic proof for the transient nature of the Th17 phenotype, 3336
Hirota, 2011, Nat Immunol, Fate mapping of IL-17-producing T cells in inflammatory responses, 255
Yang, 2009, J Exp Med, T-bet is essential for encephalitogenicity of both Th1 and Th17 cells, 1549
Lee, 2009, Immunity, Late developmental plasticity in the T helper 17 lineage, 92
Chu, 2000, J Exp Med, Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis, 123
Masters, 2010, EMBO Rep, Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production, 640
Wang, 2006, J Clin Invest, Role of IFN-gamma in induction of Foxp3 and conversion of CD4+CD25- T cells to CD4+Tregs, 2434
Yasui, 1986, Proc Natl Acad Sci USA, Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: Its possible occurrence in cancer patients, 6622
Loke, 2003, Proc Natl Acad Sci USA, PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells, 5336
Codarri, 2011, Nat Immunol, RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation, 560
Becher, 2001, J Exp Med, The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system, 967
Gerritse, 1996, Proc Natl Acad Sci USA, CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis, 2499
Grewal, 1996, Science, Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis, 1864
Korn, 2007, Nat Med, Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation, 423
Kolls, 2004, Immunity, Interleukin-17 family members and inflammation, 467
Hymowitz, 2001, EMBO J, IL-17s adopt a cystine knot fold: Structure and activity of a novel cytokine, IL-17F, and implications for receptor binding, 5332
Awane, 1999, J Immunol, NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells, 5337
Chang, 2006, J Biol Chem, Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor, 35603
Zepp, 2011, Trends Immunol, IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease, 232
Iwakura, 2011, Immunity, Functional specialization of interleukin-17 family members, 149
Ramirez-Carrozzi, 2011, Nat Immunol, IL-17C regulates the innate immune function of epithelial cells in an autocrine manner, 1159
Johnston, 2013, J Immunol, Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation, 2252
Yao, 1995, J Immunol, Human IL-17: A novel cytokine derived from T cells, 5483
Lockhart, 2006, J Immunol, IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection, 4662
Rachitskaya, 2008, J Immunol, Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion, 5167
Takatori, 2009, J Exp Med, Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22, 35
Spits, 2013, Nat Rev Immunol, Innate lymphoid cells--a proposal for uniform nomenclature, 145
Hueber, 2010, J Immunol, Mast cells express IL-17A in rheumatoid arthritis synovium, 3336
Taylor, 2014, Nat Immunol, Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2, 143
Ferretti, 2003, J Immunol, IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger, 2106
Li, 2010, J Clin Invest, IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury, 331
Yao, 1995, Immunity, Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor, 811
Hu, 2010, J Immunol, IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis, 4307
Toy, 2006, J Immunol, Cutting edge: interleukin 17 signals through a heteromeric receptor complex, 36
Huppert, 2010, FASEB J, Cellular mechanisms of IL-17-induced blood-brain barrier disruption, 1023
Numasaki, 2003, Blood, Interleukin-17 promotes angiogenesis and tumor growth, 2620
Heidenreich, 2009, Int J Exp Pathol, Angiogenesis drives psoriasis pathogenesis, 232
Pickens, 2010, J Immunol, IL-17 contributes to angiogenesis in rheumatoid arthritis, 3233
El, 2013, J Invest Dermatol, Schuler R, et al.An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling, 441
Kroenke, 2008, J Exp Med, IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition, 1535
Zehntner, 2005, J Immunol, Neutrophils that infiltrate the central nervous system regulate T cell responses, 5124
Soulika, 2009, J Neurosci, Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis, 14965
Carlson, 2008, J Exp Med, The Th17-ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease, 811
McColl, 1998, J Immunol, Treatment with anti-granulocyte antibodies inhibits the effector phase of experimental autoimmune encephalomyelitis, 6421
Aube, 2014, J Immunol, Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases, 2438
Steinbach, 2013, J Immunol, Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs, 4531
Kang, 2013, Nat Neurosci, Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+glial cells, 1401
Kreymborg, 2007, J Immunol, IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis, 8098
Laaksonen, 2014, Genes Immun, The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation, 457
Sawcer, 2011, Nature, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis, 214
Beyeen, 2010, J Immunol, IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation, 6883
Gonzalez-Garcia, 2009, J Immunol, IL-17 signaling-independent central nervous system autoimmunity is negatively regulated by TGF-beta, 2665
Haak, 2009, J Clin Invest, IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice, 61
Yang, 2015, Clin Exp Immunol, Impact of suppressing RORgammat in ameliorating central nervous system autoimmunity, 108
Xiao, 2014, Immunity, Small-molecule RORgammat antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, 477
Huh, 2011, Nature, Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity, 486
Solt, 2011, Nature, Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand, 491
El-Behi, 2011, Nat Immunol, The encephalitogenicity of T (H) 17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF, 568
Greter, 2012, Immunity, GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells, 1031
Ko, 2014, J Immunol, GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis, 2202
Sonderegger, 2008, J Exp Med, GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival, 2281
Eugster, 1998, Eur J Immunol, IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis, 2178
Agrawal, 2006, J Exp Med, Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis, 1007
Honorat, 2013, PLoS One, Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis, e71329
van, 1998, J Neuroimmunol, D., Reactive oxygen species are required for the phagocytosis of myelin by macrophages, 67
Brück, 1995, Ann Neurol, Monocyte/macrophage differentiation in early multiple sclerosis lesions, 788
Yamasaki, 2014, J Exp Med, Differential roles of microglia and monocytes in the inflamed central nervous system, 1533
Goverman, 1993, Cell, Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity, 551
Lafaille, 1994, Cell, High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice, 399
Olivares-Villagomez, 1998, J Exp Med, Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis, 1883
Pöllinger, 2009, J Exp Med, Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells, 1303
Bettelli, 2003, J Exp Med, Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis, 1073
Litzenburger, 1998, J Exp Med, B lymphocytes producing demyelinating autoantibodies: Development and function in gene-targeted transgenic mice, 169
Molnarfi, 2013, J Exp Med, MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies, 2921
Bettelli, 2006, J Clin Invest, Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice, 2393
Krishnamoorthy, 2006, J Clin Invest, Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation, 2385
Cross, 2011, Biochim Biophys Acta, MS and the B cell controversy, 231
Serafini, 2004, Brain Pathol, Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis, 164
Siffrin, 2010, Immunity, In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis, 424
Hisahara, 2000, J Neural Transm Suppl, Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death, 135
Andrews, 1998, J Neurosci Res, TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors, 574
Popko, 1999, Neurochem Res, Oligodendroglial response to the immune cytokine interferon gamma, 331
Vartanian, 1995, Mol Med, Interferon-gamma-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis, 732
Kurschus, 2005, Blood, Membrane receptors are not required to deliver granzyme B during killer cell attack, 2049
Kurschus, 2008, Proc Natl Acad Sci USA, Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis, 13799
Hoves, 2010, J Leukoc Biol, The battlefield of perforin/granzyme cell death pathways, 237
Fellows, 2007, Blood, Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program, 544
Neumann, 2002, Trends Neurosci, Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases, 313
Medana, 2001, Am J Pathol, Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes, 809
Steinman, 2001, J Exp Med, Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis, F27
Malipiero, 1997, Eur J Immunol, Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice, 3151
Beeston, 2010, J Neuroimmunol, Involvement of IFN-gamma and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis, 91
Huseby, 1999, J Immunol, Cutting edge: Myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice, 1115
Huseby, 2001, J Exp Med, A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis, 669
Sun, 2001, J Immunol, Myelin antigen-specific CD8+T cells are encephalitogenic and produce severe disease in C57BL/6 mice, 7579
Sun, 2003, Int Immunol, Encephalitogenic activity of truncated myelin oligodendrocyte glycoprotein (MOG) peptides and their recognition by CD8+MOG-specific T cells on oligomeric MHC class I molecules, 261
Ford, 2005, Eur J Immunol, Specificity, magnitude, and kinetics of MOG-specific CD8+T cell responses during experimental autoimmune encephalomyelitis, 76
Huber, 2009, Eur J Immunol, A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity, 1716
Huber, 2013, J Clin Invest, IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis, 247
Cao, 2006, Eur J Immunol, Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes, 207
Na, 2008, Brain, Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system, 2353
Saxena, 2008, J Immunol, Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes, 1617
Cabarrocas, 2003, Eur J Immunol, Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes, 1174
Owens, 2008, J Neuropathol Exp Neurol, Perivascular spaces and the two steps to neuroinflammation, 1113
Wennstrom, 2014, PLoS One, Pro-Inflammatory Cytokines Reduce the Proliferation of NG2 Cells and Increase Shedding of NG2 In Vivo and In Vitro, e109387