T cell immune reconstitution following lymphodepletion
Tóm tắt
Từ khóa
Tài liệu tham khảo
Hakim, 1997, Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells, Blood, 90, 3789, 10.1182/blood.V90.9.3789
Mackall, 2000, Prolonged CD4 depletion after sequential autologous peripheral blood progenitor cell infusions in children and young adults, Blood, 96, 754, 10.1182/blood.V96.2.754
Nordoy, 2001, Humoral immunity to viral and bacterial antigens in lymphoma patients 4–10 years after high-dose therapy with ABMT Serological responses to revaccinations according to EBMT guidelines, Bone Marrow Transplant, 28, 681, 10.1038/sj.bmt.1703228
Small, 1999, Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions, Blood, 93, 467, 10.1182/blood.V93.2.467
King, 2004, Homeostatic expansion of T cells during immune insufficiency generates autoimmunity, Cell, 117, 265, 10.1016/S0092-8674(04)00335-6
Parkman, 2006, Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation, Biol Blood Marrow Transplant, 12, 919, 10.1016/j.bbmt.2006.05.008
Dudley, 2002, Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes, Science, 298, 850, 10.1126/science.1076514
Dummer, 2002, T cell homeostatic proliferation elicits effective antitumor autoimmunity, J Clin Invest, 110, 185, 10.1172/JCI0215175
Gattinoni, 2005, Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells, J Exp Med, 202, 907, 10.1084/jem.20050732
Wrzesinski, 2007, Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells, J Clin Invest, 117, 492, 10.1172/JCI30414
Mackall, 1997, Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy, Immunol Rev, 157, 61, 10.1111/j.1600-065X.1997.tb00974.x
Mackall, 1995, Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy, N Engl J Med, 332, 143, 10.1056/NEJM199501193320303
Mackall, 1993, T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny, Blood, 82, 2585, 10.1182/blood.V82.8.2585.2585
Hakim, 2005, Age-dependent incidence, time course, and consequences of thymic renewal in adults, J Clin Invest, 115, 930, 10.1172/JCI200522492
Ge, 2002, Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments, Proc Natl Acad Sci USA, 99, 2989, 10.1073/pnas.052714099
Douek, 2000, Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution, Lancet, 355, 1875, 10.1016/S0140-6736(00)02293-5
Douek, 1998, Changes in thymic function with age and during the treatment of HIV infection, Nature, 396, 690, 10.1038/25374
Wu, 2000, Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism, Blood, 95, 352, 10.1182/blood.V95.1.352
Klein, 2001, T-Cell recovery in adults and children following umbilical cord blood transplantation, Biol Blood Marrow Transplant, 7, 454, 10.1016/S1083-8791(01)80013-6
Lewin, 2002, Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations, Blood, 100, 2235, 10.1182/blood.V100.6.2235
Fredrickson, 1994, Early thymic regeneration after irradiation, Dev Comp Immunol, 18, 251, 10.1016/0145-305X(94)90017-5
Sfikakis, 2005, Age-related thymic activity in adults following chemotherapy-induced lymphopenia, Eur J Clin Invest, 35, 380, 10.1111/j.1365-2362.2005.01499.x
Smith, 2000, Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy, J Infect Dis, 181, 141, 10.1086/315169
Teixeira, 2001, Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function, AIDS, 15, 1749, 10.1097/00002030-200109280-00002
Dion, 2004, HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation, Immunity, 21, 757, 10.1016/j.immuni.2004.10.013
Fallen, 2003, Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients, Bone Marrow Transplant, 32, 1001, 10.1038/sj.bmt.1704235
Haynes, 2000, The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection, Annu Rev Immunol, 18, 529, 10.1146/annurev.immunol.18.1.529
Mackall, 1998, Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution, Eur J Immunol, 28, 1886, 10.1002/(SICI)1521-4141(199806)28:06<1886::AID-IMMU1886>3.0.CO;2-M
Sarzotti, 2003, T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation, J Immunol, 170, 2711, 10.4049/jimmunol.170.5.2711
Nordoy, 1999, Persistent changes in the immune system 4–10 years after ABMT, Bone Marrow Transplant, 24, 873, 10.1038/sj.bmt.1702006
Storek, 2001, Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation, Blood, 98, 3505, 10.1182/blood.V98.13.3505
Almeida, 2001, T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors, J Exp Med, 194, 591, 10.1084/jem.194.5.591
Min, 2004, Reduction in the developmental potential of intrathymic T cell progenitors with age, J Immunol, 173, 245, 10.4049/jimmunol.173.1.245
Heng, 2005, Effects of castration on thymocyte development in two different models of thymic involution, J Immunol, 175, 2982, 10.4049/jimmunol.175.5.2982
Talvensarri, 2002, A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation, Blood, 99, 1458, 10.1182/blood.V99.4.1458
Chen, 2004, Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation, Blood, 103, 4344, 10.1182/blood-2003-07-2534
Zakrzewski, 2006, Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation, Nat Med, 12, 1039, 10.1038/nm1463
Peschon, 1994, Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice, J Exp Med, 180, 1955, 10.1084/jem.180.5.1955
Andrew, 2002, Age-associated thymic atrophy is linked to a decline in IL-7 production, Exp Gerontol, 37, 455, 10.1016/S0531-5565(01)00213-3
Phillips, 2004, IL-7 gene therapy in aging restores early thymopoiesis without reversing involution, J Immunol, 173, 4867, 10.4049/jimmunol.173.8.4867
Bolotin, 1996, Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7, Blood, 88, 1887, 10.1182/blood.V88.5.1887.1887
Mackall, 2001, IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation, Blood, 97, 1491, 10.1182/blood.V97.5.1491
Li, 2006, Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice, Gene Ther, 13, 1178, 10.1038/sj.gt.3302741
Chu, 2004, Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function, Blood, 104, 1110, 10.1182/blood-2003-10-3635
Adachi, 2005, Semiquantitative detection of cytokine messages in X-irradiated and regenerating rat thymus, Radiat Res, 163, 400, 10.1667/RR3331
Alpdogan, 2006, Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration, Blood, 107, 2453, 10.1182/blood-2005-07-2831
Rossi, 2002, Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease, Blood, 100, 682, 10.1182/blood.V100.2.682
Rossi, 2007, Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells, Blood, 109
Napolitano, 2002, Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone, AIDS, 16, 1103, 10.1097/00002030-200205240-00003
Savino, 2002, The thymus gland: a target organ for growth hormone, Scand J Immunol, 55, 442, 10.1046/j.1365-3083.2002.01077.x
Polgreen, 2007, Thymic hyperplasia in a child treated with growth hormone, Growth Horm IGF Res, 17, 41, 10.1016/j.ghir.2006.10.005
Olsen, 2001, Androgen receptors in thymic epithelium modulate thymus size and thymocyte development, Endocrinology, 142, 1278, 10.1210/endo.142.3.8032
Sutherland, 2005, Activation of thymic regeneration in mice and humans following androgen blockade, J Immunol, 175, 2741, 10.4049/jimmunol.175.4.2741
Goldberg, 2005, Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation, Transplantation, 80, 1604, 10.1097/01.tp.0000183962.64777.da
Roux, 2000, Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity, Blood, 96, 2299, 10.1182/blood.V96.6.2299
Dumont-Girard, 1998, Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants, Blood, 92, 4464, 10.1182/blood.V92.11.4464
Muraro, 2006, Renewing the T cell repertoire to arrest autoimmune aggression, Trends Immunol, 27, 61, 10.1016/j.it.2005.12.003
Fry, 2005, The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance, J Immunol, 174, 6571, 10.4049/jimmunol.174.11.6571
Hazenberg, 2002, T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events, Blood, 99, 3449, 10.1182/blood.V99.9.3449
Bellucci, 2002, Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma, Blood, 99, 4610, 10.1182/blood.V99.12.4610
Hochberg, 2001, Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults, Blood, 98, 1116, 10.1182/blood.V98.4.1116
Schluns, 2000, Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo, Nat Immunol, 1, 426, 10.1038/80868
Tan, 2001, IL-7 is critical for homeostatic proliferation and survival of naive T cells, Proc Natl Acad Sci USA, 98, 8732, 10.1073/pnas.161126098
Fry, 2001, Interleukin-7 restores immunity in athymic T-cell-depleted hosts, Blood, 97, 1525, 10.1182/blood.V97.6.1525
Fry, 2003, IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates, Blood, 101, 2294, 10.1182/blood-2002-07-2297
Moniuszko, 2004, Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo, J Virol, 78, 9740, 10.1128/JVI.78.18.9740-9749.2004
Rosenberg, 2006, IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells, J Immunother, 29, 313, 10.1097/01.cji.0000210386.55951.c2
Li, 2004, Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival, J Biol Chem, 279, 29160, 10.1074/jbc.M401656200
Schober, 1999, Expression of the transcription factor lung Kruppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo, J Immunol, 163, 3662, 10.4049/jimmunol.163.7.3662
Sasson, 2006, Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection, J Infect Dis, 193, 505, 10.1086/499309
Vassena, 2007, Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals, Proc Natl Acad Sci USA, 104, 2355, 10.1073/pnas.0610775104
Park, 2004, Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival, Immunity, 21, 289, 10.1016/j.immuni.2004.07.016
Bolotin, 1999, Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count, Bone Marrow Transplant, 23, 783, 10.1038/sj.bmt.1701655
Fry, 2001, A potential role for interleukin-7 in T-cell homeostasis, Blood, 97, 2983, 10.1182/blood.V97.10.2983
Kennedy, 2000, Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice, J Exp Med, 191, 771, 10.1084/jem.191.5.771
Schluns, 2002, Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells, J Immunol, 168, 4827, 10.4049/jimmunol.168.10.4827
Lodolce, 1998, IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation, Immunity, 9, 669, 10.1016/S1074-7613(00)80664-0
Yajima, 2006, IL-15 regulates CD8+ T cell contraction during primary infection, J Immunol, 176, 507, 10.4049/jimmunol.176.1.507
Li, 2005, IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro, J Immunol, 174, 4019, 10.4049/jimmunol.174.7.4019
Anichini, 2003, Differentiation of CD8+ T cells from tumor-invaded and tumor-free lymph nodes of melanoma patients: role of common gamma-chain cytokines, J Immunol, 171, 2134, 10.4049/jimmunol.171.4.2134
Cooley, 2007, Adoptive therapy with T Cells/NK Cells, Biol Blood Marrow Transplant, 13, 33, 10.1016/j.bbmt.2006.10.008
Chik, 2003, Elevated serum interleukin-15 level in acute graft-versus-host disease after hematopoietic cell transplantation, J Pediatr Hematol Oncol, 25, 960, 10.1097/00043426-200312000-00011
Mackall, 1997, Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy, Blood, 89, 3700, 10.1182/blood.V89.10.3700
Ferrari, 2006, Distinct patterns of regeneration of central memory, effector memory and effector TCD8+ cell subsets after different hematopoietic cell transplant types: possible influence in the recovery of anti-cytomegalovirus immune response and risk for its reactivation, Clin Immunol, 119, 261, 10.1016/j.clim.2005.12.001
Geginat, 2003, Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines, Blood, 101, 4260, 10.1182/blood-2002-11-3577
Judge, 2002, Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells, J Exp Med, 196, 935, 10.1084/jem.20020772
Zeng, 2005, Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function, J Exp Med, 201, 139, 10.1084/jem.20041057
Moroz, 2004, IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21, J Immunol, 173, 900, 10.4049/jimmunol.173.2.900
Lucas, 2000, Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor, J Exp Med, 191, 1187, 10.1084/jem.191.7.1187
Lucas, 2004, Transforming growth factor-beta pathway serves as a primary tumor suppressor in CD8+ T cell tumorigenesis, Cancer Res, 64, 6524, 10.1158/0008-5472.CAN-04-0896
Lucas, 2006, Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice, Blood, 108, 2789, 10.1182/blood-2006-05-025676
Ahmadzadeh, 2005, TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells, J Immunol, 174, 5215, 10.4049/jimmunol.174.9.5215
Liu, 2006, CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells, J Exp Med, 203, 1701, 10.1084/jem.20060772
Sakaguchi, 2006, Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease, Immunol Rev, 212, 8, 10.1111/j.0105-2896.2006.00427.x
Ku, 2000, Control of homeostasis of CD8+ memory T cells by opposing cytokines, Science, 288, 675, 10.1126/science.288.5466.675
Kamimura, 2004, Evidence of a novel IL-2/15R beta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells, J Immunol, 173, 6041, 10.4049/jimmunol.173.10.6041
Kursar, 2002, Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses, J Exp Med, 196, 1585, 10.1084/jem.20011347
Almeida, 2002, Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers, J Immunol, 169, 4850, 10.4049/jimmunol.169.9.4850
Shen, 2005, Control of homeostatic proliferation by regulatory T cells, J Clin Invest, 115, 3517, 10.1172/JCI25463
Nguyen, 2006, Role of naturally arising regulatory T cells in hematopoietic cell transplantation, Biol Blood Marrow Transplant, 12, 995, 10.1016/j.bbmt.2006.04.009
Rezvani, 2006, High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT, Blood, 108, 1291, 10.1182/blood-2006-02-003996
Zhang, 2005, Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells, Nat Med, 11, 1238, 10.1038/nm1312
Mackall, 1996, Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing, J Immunol, 156, 4609, 10.4049/jimmunol.156.12.4609
Min, 2003, Neonates support lymphopenia-induced proliferation, Immunity, 18, 131, 10.1016/S1074-7613(02)00508-3
Min, 2005, Endogenous proliferation: burst-like CD4 T cell proliferation in lymphopenic settings, Semin Immunol, 17, 201, 10.1016/j.smim.2005.02.005
Kieper, 2005, Recent immune status determines the source of antigens that drive homeostatic T cell expansion, J Immunol, 174, 3158, 10.4049/jimmunol.174.6.3158
Chalandon, 2006, Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications, Blood, 107, 389, 10.1182/blood-2005-07-2746
Ganepola, 2007, Patients at high risk for CMV infection and disease show delayed CD8+ T-cell immune recovery after allogeneic stem cell transplantation, Bone Marrow Transplant, 39, 293, 10.1038/sj.bmt.1705585
Peggs, 2003, Reconstitution of T-cell repertoire after autologous stem cell transplantation: influence of CD34 selection and cytomegalovirus infection, Biol Blood Marrow Transplant, 9, 198, 10.1016/S1083-8791(03)70010-X
Ma, 2003, Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution, Eur J Immunol, 33, 2123, 10.1002/eji.200324034
Borrello, 2000, Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines, Blood, 95, 3011, 10.1182/blood.V95.10.3011
Antony, 2006, Interleukin-2-dependent mechanisms of tolerance and immunity in vivo, J Immunol, 176, 5255, 10.4049/jimmunol.176.9.5255
Kochenderfer, 2006, Synergism between CpG-containing oligodeoxynucleotides and IL-2 causes dramatic enhancement of vaccine-elicited CD8+ T cell responses, J Immunol, 177, 8860, 10.4049/jimmunol.177.12.8860
Pasare, 2003, Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells, Science, 299, 1033, 10.1126/science.1078231
Oh, 2003, Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity, Proc Natl Acad Sci USA, 100, 3392, 10.1073/pnas.0630592100
Di Carlo, 2004, IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice, J Immunol, 172, 1540, 10.4049/jimmunol.172.3.1540
Dudley, 2005, Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma, J Clin Oncol, 23, 2346, 10.1200/JCO.2005.00.240
Robbins, 2004, Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy, J Immunol, 173, 7125, 10.4049/jimmunol.173.12.7125
Shen, 2007, Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length, J Immunother, 30, 123, 10.1097/01.cji.0000211321.07654.b8
Ahmadzadeh, 2006, IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients, Blood, 107, 2409, 10.1182/blood-2005-06-2399
Morgan, 2006, Cancer regression in patients after transfer of genetically engineered lymphocytes, Science, 314, 126, 10.1126/science.1129003
Hakim, 1996, Immunopathogenesis of graft vs host disease, 257
Muluk, 1992, Regulation of graft-versus-host-reaction by Mlsa-reactive donor T cells, Eur J Immunol, 22, 1967, 10.1002/eji.1830220803
van den Brink, 2000, Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity, Transplantation, 69, 446, 10.1097/00007890-200002150-00026
Hakim, 1991, Repopulation of host lymphohematopoietic systems by donor cells during graft-versus-host reaction in unirradiated adult F1 mice injected with parental lymphocytes, J Immunol, 146, 2108, 10.4049/jimmunol.146.7.2108
Sinha, 2002, Interleukin 7 worsens graft-versus-host disease, Blood, 100, 2642, 10.1182/blood-2002-04-1082
Alpdogan, 2001, Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease, Blood, 98, 2256, 10.1182/blood.V98.7.2256
Gendelman, 2004, Host conditioning is a primary determinant in modulating the effect of IL-7 on murine graft-versus-host disease, J Immunol, 172, 3328, 10.4049/jimmunol.172.5.3328
Blaser, 2005, Donor-derived IL-15 is critical for acute allogeneic graft-versus-host disease, Blood, 105, 894, 10.1182/blood-2004-05-1687
Alpdogan, 2005, Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation, Blood, 105, 865, 10.1182/blood-2003-09-3344
Roychowdhury, 2005, IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease, Blood, 106, 2433, 10.1182/blood-2005-04-1597
Kumaki, 1998, Prolonged secretion of IL-15 in patients with severe forms of acute graft-versus-host disease after allogeneic bone marrow transplantation in children, Int J Hematol, 67, 307, 10.1016/S0925-5710(97)00117-5
Via, 1990, Synergistic effect of murine cytomegalovirus on the induction of acute graft-vs.-host disease involving MHC class I differences only. Analysis of in vitro T cell function, J Immunol, 145, 3283, 10.4049/jimmunol.145.10.3283
Levy, 1990, HSV-1 enhances GvHR-associated parent anti-F1 alloreactivity in vivo and in vitro, Cell Immunol, 129, 1, 10.1016/0008-8749(90)90181-P
Trenado, 2006, Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells, J Immunol, 176, 1266, 10.4049/jimmunol.176.2.1266
Taylor, 2002, The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality, Blood, 99, 3493, 10.1182/blood.V99.10.3493
Nguyen, 2007, In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation, Blood, 109, 2649, 10.1182/blood-2006-08-044529
Hollander, 1994, Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs. host disease, J Immunol, 152, 1609, 10.4049/jimmunol.152.4.1609
Desbarats, 1993, Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions, J Exp Med, 178, 805, 10.1084/jem.178.3.805
Ghayur, 1988, Complete sequential regeneration of graft-vs.-host-induced severely dysplastic thymuses. Implications for the pathogenesis of chronic graft-vs.-host disease, Am J Pathol, 133, 39
Hauri-Hohl, 2007, Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation, Blood, 109, 4080, 10.1182/blood-2006-07-034157
Watanabe, 2005, Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus, Nature, 436, 1181, 10.1038/nature03886
Jimenez, 2006, Clinical factors influencing T-cell receptor excision circle (TRECs) counts following allogeneic stem cell transplantation in adults, Transpl Immunol, 16, 52, 10.1016/j.trim.2006.02.006
Weinberg, 2001, Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation, Blood, 97, 1458, 10.1182/blood.V97.5.1458