T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC

Liblau, 1995, Th1–Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases, Immunol. Today, 16, 34, 10.1016/0167-5699(95)80068-9

Chambers, 1997, Co-stimulation in T cell responses, Curr. Opin. Immumol., 9, 396, 10.1016/S0952-7915(97)80087-8

Lenschow, 1996, CD28/B7 system of T cell costimulation, Annu. Rev. Immunol., 14, 233, 10.1146/annurev.immunol.14.1.233

June, 1994, The B7 and CD28 receptor families, Immunol. Today, 15, 321, 10.1016/0167-5699(94)90080-9

Schwartz, 1997, T cell clonal anergy, Curr. Opin. Immunol., 9, 351, 10.1016/S0952-7915(97)80081-7

Chan, 1994, The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction, Annu. Rev. Immunol., 12, 555, 10.1146/annurev.iy.12.040194.003011

Fraser, 1991, Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28, Science, 251, 313, 10.1126/science.1846244

Butscher, 1998, Coordinate transactivation of the interleukin-2 response element by c-Rel and ATF-1/CREB2, J. Biol. Chem., 273, 552, 10.1074/jbc.273.1.552

Rothenberg, 1996, A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin-2 gene regulation, Proc. Natl. Acad. Sci. USA, 93, 9358, 10.1073/pnas.93.18.9358

Lu, 1992, CD28-induced T cell activation: evidence for a protein–tyrosine kinase signal transduction pathway, J. Immunol., 149, 24, 10.4049/jimmunol.149.1.24

Hahaj, 1996, CD28 mediates a potent costimulatory signal for the rapid degradation of IκBβ which is associated with accelerated activation of various NF-κB/Rel heterodimers, Mol. Cell Biol., 16, 6736, 10.1128/MCB.16.12.6736

Rao, 1997, Transcription factors of the NFAT family: regulation and function, Annu. Rev. Immunol., 15, 707, 10.1146/annurev.immunol.15.1.707

Liu, 1991, Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP–FK506 complexes, Cell, 66, 807, 10.1016/0092-8674(91)90124-H

Nissen, 2000, The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain, Genes Dev., 14, 2314, 10.1101/gad.827900

Morris, 1995, In transplantation of the liver; new immunosuppressive drugs, 760

Crabtree, 1989, Contingent genetic regulatory events in T lymphocyte activation, Science, 243, 355, 10.1126/science.2783497

Adams, 1992, Sequence identification of 2375 human brain genes, Nature, 355, 632, 10.1038/355632a0

Tam, 2001, Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA, Gene, 274, 157, 10.1016/S0378-1119(01)00612-6

Altschul, 1997, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res., 25, 3389, 10.1093/nar/25.17.3389

Pearson, 1997, Comparison of DNA sequences with protein sequences, Genomics, 46, 24, 10.1006/geno.1997.4995

J. Sambrook, E.F. Fritsch, T. Maniatis (Eds.) Extraction, purification, and analysis of messenger RNA from eukaryotic cells, in: Molecular Cloning: A Laboratory Manual, vol. 1, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989, p. 7.43

Dubey, 1996, Naı̈ve and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals, J. Immunol., 157, 3280, 10.4049/jimmunol.157.8.3280

Griffith, 1995, X-ray structure of calcineurin inhibited by the immunophilin–immunosuppressant FKBP12–FK506 complex, Cell, 82, 507, 10.1016/0092-8674(95)90439-5

Kissinger, 1995, Crystal structures of human calcineurin and the human FKBP12–FK506-calcineurin complex, Nature, 378, 641, 10.1038/378641a0

Hemenway, 1999, Calcineurin. structure, function, and inhibition, Cell Biochem. Biophys., 30, 115, 10.1007/BF02737887

Lawrence, 1997, PHAS-I/4E-BPs as regulators of mRNA translation and cell proliferation, Trends Biochem. Sci., 22, 345, 10.1016/S0968-0004(97)01101-8

Clurman, 1989, Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events, Mol. Cell Biol., 9, 2651, 10.1128/MCB.9.6.2657

Tam, 1997, bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA, Mol. Cell Biol., 17, 1490, 10.1128/MCB.17.3.1490

Gura, 2000, A silence that speaks volumes, Nature, 404, 804, 10.1038/35009245

Kuo, 1997, LKLF: a transcriptional regulator of single-positive T cell quiescence and survival, Science, 277, 1986, 10.1126/science.277.5334.1986

Liu, 2001, Augmentation in expression of activation-induced genes differentiates memory from naı̈ve CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells, J. Immunol., 166, 7335, 10.4049/jimmunol.166.12.7335

Askew, 1999, New insights into the function of noncoding RNA and its potential role in disease pathogenesis, Histol. Histopathol., 14, 235

Erdmann, 2001, Regulatory RNAs, Cell. Mol. Life Sci., 58, 960, 10.1007/PL00000913

Brown, 1991, A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome, Nature, 349, 38, 10.1038/349038a0

Lyon, 1994, The X-inactivation center and X-chromosome imprinting, Eur. J. Human Genet., 2, 255, 10.1159/000472369

Penny, 1996, Requirement for Xist in X-chromosome inactivation, Nature, 379, 131, 10.1038/379131a0