T-Box Genes in Vertebrate Development

Annual Review of Genetics - Tập 39 Số 1 - Trang 219-239 - 2005
L.A. Naiche1, Zachary Harrelson2,3, Robert G. Kelly2,4, Virginia E. Papaioannou2,3
1Department of Genetics and Development, College of Physicians and Surgeons, of Columbia University, New York, New York 10032, USA
2Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032
3Institut de Biologie du Developpement de Marseille
4Developmental Biology Institute of Marseilles, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France;

Tóm tắt

The myriad developmental roles served by the T-box family of transcription factor genes defy easy categorization. Present in all metazoans, the T-box genes are involved in early embryonic cell fate decisions, regulation of the development of extraembryonic structures, embryonic patterning, and many aspects of organogenesis. They are unusual in displaying dosage sensitivity in most instances. In humans, mutations in T-box genes are responsible for developmental dysmorphic syndromes, and several T-box genes have been implicated in neoplastic processes. T-box transcription factors function in many different signaling pathways, notably bone morphogenetic protein and fibroblast growth factor pathways. The few downstream target genes that have been identified indicate a wide range of downstream effectors.

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Annual Review of Genetics

Tập 39 Số 1

219-239

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