Systolic and diastolic function in middle aged patients with sickle β thalassaemia. An echocardiographic study

Postgraduate Medical Journal - Tập 81 Số 961 - Trang 711-714 - 2005
Ioannis Moyssakis1, Revekka Tzanetea2, Panayiotis Tsaftaridis3, Ioannis Rombos2, Dimitrios Papadopoulos1, Vassiliki Kalotychou2, Athanasios Aessopos2
1Cardiology Department, Laiko General Hospital, Athens, Greece
2First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, Athens, Greece
3Thalassemia Department, Laiko General Hospital , Athens , Greece

Tóm tắt

Abstract Objective To evaluate the right and left ventricular systolic and diastolic function in middle aged patients with sickle β thalassaemia. Methods Forty three patients with sickle β thalassaemia were recruited for echocardiographic study while 55 controls, matched for age and sex, served as the control group. Parameters measured included: dimensions and wall thickness of left (LV) and right (RV) ventricle and left atrium, LV mass, and cardiac index. LV and RV contractility variables—ejection fraction, circumferential fibre shortening velocity, end systolic stress, end systolic stress/volume index ratio, mitral and tricuspid annulus systolic excursion, and Tei index—were also calculated. The study also evaluated parameters of RV and LV diastolic function including early and late atrioventricular flow velocities (E and A wave respectively), E/A ratio, deceleration time (DT), isovolumic relaxation time (IVRT) as well as pulmonary and hepatic veins systolic to diastolic (S/D) ratio. Results Chamber enlargement, greater LV mass index, cardiac index, and RV wall thickness were found in the anaemic group compared with controls. The LV and RV contractility variables of the patients were similar to controls. Conversely the LV and RV Tei index was significantly greater in the patient group. Diastolic dysfunction was present in the anaemic patients resulting from the increased LV and RV A-wave, the longer LVIVRT, RVIVRT, and RVDT, as well as the higher hepatic and pulmonary veins S/D ratio. Conclusions The results show that in middle aged patients with sickle β thalassaemia the diastolic function is abnormal in both ventricles but still more in RV, whereas the systolic function remains unchanged.

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Tài liệu tham khảo

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Postgraduate Medical Journal

Tập 81 Số 961

711-714

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