Systemic lupus erythematosus and increased risk to develop B cell malignancies: Role of the p200-family proteins

Kotzin, 1996, Systemic lupus erythematosus, Cell, 85, 303, 10.1016/S0092-8674(00)81108-3 Crispín, 2010, Pathogenesis of human systemic lupus erythematosus: recent advances, Trends Mol Med, 16, 47, 10.1016/j.molmed.2009.12.005 Pisetsky, 2008, The role of innate immunity in the induction of autoimmunity, Autoimmun Rev, 8, 69, 10.1016/j.autrev.2008.07.028 Baccala, 2005, Interferons as pathogenic effectors in autoimmunity, Immunol Rev, 204, 9, 10.1111/j.0105-2896.2005.00252.x Theofilopoulos, 2005, Type I interferons (alpha/beta) in immunity and autoimmunity, Annu Rev Immunol, 23, 307, 10.1146/annurev.immunol.23.021704.115843 Borden, 2007, Interferons at age 50: past, current and future impact on biomedicine, Nat Rev Drug Discov, 6, 975, 10.1038/nrd2422 Banchereau, 2006, Type I interferon in systemic lupus erythematosus and other autoimmune diseases, Immunity, 25, 383, 10.1016/j.immuni.2006.08.010 Su, 1999, Inhibition of B cell receptor-mediated apoptosis by IFN, J Immunol, 162, 6317, 10.4049/jimmunol.162.11.6317 Gayed, 2009, Lupus and cancer, Lupus, 18, 479, 10.1177/0961203309102556 Bernatsky, 2009, Malignancy in systemic lupus erythematosus: what have we learned?, Best Pract Res Clin Rheumatol, 23, 539, 10.1016/j.berh.2008.12.007 Santiago-Raber, 2003, Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice, J Exp Med, 197, 777, 10.1084/jem.20021996 Mellors, 1966, Autoimmune disease in NZB-Bl mice. II. Autoimmunity and malignant lymphoma, Blood, 27, 435, 10.1182/blood.V27.4.435.435 Sugai, 1974, Protective and cellular immune responses to idiotypic determinants on cells from a spontaneous lymphoma of NZB-NZW F1 mice, J Exp Med, 140, 1547, 10.1084/jem.140.6.1547 Scaglione, 2007, Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model, Br J Haematol, 139, 645, 10.1111/j.1365-2141.2007.06851.x Harris, 2005, The p53 pathway: positive and negative feedback loops, Oncogene, 24, 2899, 10.1038/sj.onc.1208615 Oren, 2003, Decision making by p53: life, death and cancer, Cell Death Differ, 10, 431, 10.1038/sj.cdd.4401183 Ichikawa, 1997, Mutations of the p53 gene as a prognostic factor in aggressive B-cell lymphoma, N Engl J Med, 337, 529, 10.1056/NEJM199708213370804 Dolcetti, 1996, Cellular and molecular bases of B-cell clonal expansions, Clin Exp Rheumatol, S3 Buttgereit, 2001, Effects of adenoviral wild-type p53 gene transfer in p53-mutated lymphoma cells, Cancer Gene Ther, 8, 430, 10.1038/sj.cgt.7700323 Rathmell, 2002, Pathways of apoptosis in lymphocyte development, homeostasis, and disease, Cell, S97, 10.1016/S0092-8674(02)00704-3 Miret, 2003, Relationship of p53 with other oncogenes, cytokines and systemic lupus erythematosus activity, Tumour Biol, 24, 185, 10.1159/000074428 Hoffman, 2002, Transcriptional repression of the anti-apoptotic survivin gene by wild type p53, J Biol Chem, 277, 3247, 10.1074/jbc.M106643200 D'Souza, 2001, The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression, J Biol Chem, 276, 298, 10.1074/jbc.M007155200 Chipuk, 2004, Cytoplasmic p53: bax and forward, Cell Cycle, 3, 429, 10.4161/cc.3.4.821 Baptiste, 2004, p53 in the cytoplasm: a question of overkill?, Cell, 116, 487, 10.1016/S0092-8674(04)00164-3 Erster, 2004, In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation, Mol Cell Biol, 24, 6728, 10.1128/MCB.24.15.6728-6741.2004 Takaoka, 2003, Integration of interferon-alpha/beta signaling to p53 responses in tumor suppression and antiviral defense, Nature, 424, 516, 10.1038/nature01850 Kuan, 2005, p53 is required for spontaneous autoantibody production in B6/lpr lupus mice, Eur J Immunol, 35, 1653, 10.1002/eji.200525982 Salvador, 2002, Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome, Immunity, 16, 499, 10.1016/S1074-7613(02)00302-3 Balomenos, 2000, The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development, Nat Med, 6, 171, 10.1038/72272 Zheng, 2005, Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function, Diabetes, 54, 1423, 10.2337/diabetes.54.5.1423 Murphy, 2003, The thousand doors that lead to death: p53-dependent repression and apoptosis, Cancer Biol Ther, 2, 381, 10.4161/cbt.2.4.439 Venot, 1998, The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression, EMBO J, 17, 4668, 10.1093/emboj/17.16.4668 Slatter, 2010, p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors, Cell Death Differ, 17, 540, 10.1038/cdd.2009.136 Choubey, 2002, Interferon-inducible p202 in the susceptibility to systemic lupus, Front Biosci, 7, e252, 10.2741/choubey Choubey, 2008, Interferon-inducible Ifi200-family genes in systemic lupus erythematosus, Immunol Lett, 119, 32, 10.1016/j.imlet.2008.06.001 Wang, 1999, Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200-cluster, Genomics, 60, 281, 10.1006/geno.1999.5923 Albrecht, 2005, The HIN domain of IFI-200 proteins consists of two OB-folds, Biochem Biophys Res Commun, 327, 679, 10.1016/j.bbrc.2004.12.056 Choubey, 2010, Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity, J Interferon Cytokine Res, 30, 371, 10.1089/jir.2009.0096 Panchanathan, 2009, Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval, J Immunol, 183, 7031, 10.4049/jimmunol.0802665 Rozzo, 2001, Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus, Immunity, 15, 435, 10.1016/S1074-7613(01)00196-0 Choubey, 2003, Sub-cellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility, FEBS Lett, 553, 245, 10.1016/S0014-5793(03)01006-8 Roberts, 2009, HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA, Science, 323, 1057, 10.1126/science.1169841 Choubey, 2010, Comment on “Development of murine lupus involves the combined genetic contribution of the SLAM and FcγR intervals within the Nba2 autoimmune susceptibility locus”, J Immunol, 184, 4051, 10.4049/jimmunol.1090015 Choubey, 1993, Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kDa protein that is encoded by the Ifi200-gene from the gene 200-cluster, J Interferon Res, 13, 43, 10.1089/jir.1993.13.43 Xin, 2006, Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis, J Immunol, 176, 5863, 10.4049/jimmunol.176.10.5863 Huxford, 1999, Structure and mechanism in NF-kappa B/I kappa B signaling, Cold Spring Harb Symp Quant Biol, 64, 533, 10.1101/sqb.1999.64.533 Vallabhapurapu, 2009, Regulation and function of NF-kappaB transcription factors in the immune system, Annu Rev Immunol, 27, 693, 10.1146/annurev.immunol.021908.132641 Do, 2002, Mechanism of BLyS action in B cell immunity, Cytokine Growth Factor Rev, 13, 19, 10.1016/S1359-6101(01)00025-9 Laâbi, 2000, Immunology. Lymphocyte survival – ignorance is BLys, Science, 289, 883, 10.1126/science.289.5481.883 Mackay, 1999, Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations, J Exp Med, 190, 1697, 10.1084/jem.190.11.1697 Enzler, 2006, Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease, Immunity, 25, 403, 10.1016/j.immuni.2006.07.010 Wu, 2007, Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus, J Clin Invest, 117, 2186, 10.1172/JCI30398 Kalergis, 2009, Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus, Immunology, 128, e306, 10.1111/j.1365-2567.2008.02964.x Dai, 2007, Despite inhibition of nuclear localization of NF-kappa B p65, c-Rel, and RelB, 17-beta estradiol up-regulates NF-kappa B signaling in mouse splenocytes: the potential role of Bcl-3, J Immunol, 179, 1776, 10.4049/jimmunol.179.3.1776 Yang, 2005, Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival, J Biol Chem, 280, 31530, 10.1074/jbc.M503120200 Min, 1996, The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities, Mol Cell Biol, 16, 359, 10.1128/MCB.16.1.359 Ma, 2003, The interferon-inducible p202a protein modulates NF-κB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers, J Biol Chem, 278, 23008, 10.1074/jbc.M302105200 Yamauchi, 2007, Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells, Int Immunol, 19, 935, 10.1093/intimm/dxm054 Ryan, 2000, Role of NF-kappaB in p53-mediated programmed cell death, Nature, 404, 892, 10.1038/35009130 Feng, 2004, NF-kB inhibitor blocks B cell development at two checkpoints, Med Immunol, 3, 1, 10.1186/1476-9433-3-1 Choubey, 2008, Interferon-inducible IFI16 protein in human cancers and autoimmune diseases, Front Biosci, 13, 598, 10.2741/2705 Johnstone, 2000, Functional interaction between 53p and the interferon-inducible nucleoprotein IFI 16, Oncogene, 19, 6033, 10.1038/sj.onc.1204005 Kwak, 2003, IFI16 as a negative regulator in the regulation of p53 and p21(Waf1), J Biol Chem, 278, 40899, 10.1074/jbc.M308012200 Song, 2008, Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53, Mol Cancer Res, 6, 1732, 10.1158/1541-7786.MCR-08-0208 Lee, 2005, The functional p53 codon 72 polymorphism is associated with systemic lupus erythematosus, Lupus, 14, 842, 10.1191/0961203305lu2224oa Hoshida, 2005, TP53 gene mutation, an unfavorable prognostic factor for malignant lymphomas in autoimmune diseases, Oncology, 69, 175, 10.1159/000087980 Caposio, 2007, A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells, J Biol Chem, 282, 33515, 10.1074/jbc.M701846200