Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice

Transplantation - Tập 78 Số 1 - Trang 83-88 - 2004
Baijun Fang1,2,3,4,5, Mingxia Shi1,2,3,4,5, Lianming Liao1,2,3,4,5, Shaoguang Yang1,2,3,4,5, Yuhao Liu1,2,3,4,5, Robert Chunhua Zhao1,2,3,4,5
1Baijun Fang and Mingxia Shi contributed equally to this work.
2RCH Zhao is a Cheung Kong Scholar in P.R. China.
3Received 2 December 2003. Accepted 21 January 2004.
4Sino-American Collaborative Laboratory, State Key Lab of Experimental Haematology, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Tissue Engineering Center, Chinese Academy of Medical Sciences, Tianjin, China.
5This study was supported by “863 projects” of the Ministry of Science and Technology of P.R. China (No. 2002AA205061), China Medical Board of New York, Inc (Grant #01–748), and the National Natural Science Foundation of China (No. 30070284)

Tóm tắt

Từ khóa


Tài liệu tham khảo

Iredale, 2003, Cirrhosis: new research provides a basis for rational and targeted treatments., BMJ, 327, 143, 10.1136/bmj.327.7407.143

Fang, 2003, Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31−/CD34− progenitors., J Hematother Stem Cell Res, 12, 603, 10.1089/15258160360732632

Kakinuma, 2003, Human umbilical cord blood as a source of transplantable hepatic progenitor cells., Stem Cells, 21, 217, 10.1634/stemcells.21-2-217

Mallet, 2002, Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo., Hepatology, 35, 799, 10.1053/jhep.2002.32530

Turkdogan, 2003, The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride-induced hepatotoxicity in rats., Phytother Res, 17, 942, 10.1002/ptr.1266

Wang, 2003, Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis., World J Gastroenterol, 9, 1287, 10.3748/wjg.v9.i6.1287

Yoshiji, 2003, Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis., Gut, 52, 1347, 10.1136/gut.52.9.1347

Fang, 2004, Multipotency of Flk1+ CD34− progenitors derived from human fetal bone marrow., J Lab Clin Med, 143, 230, 10.1016/j.lab.2003.11.008

Reyes, 2001, Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells., Blood, 98, 2615, 10.1182/blood.V98.9.2615

Guo, 2003, Hemangioblastic characteristics of fetal bone marrow-derived Flk1(+)CD31(-)CD34(-) cells., Exp Hematol, 31, 650, 10.1016/S0301-472X(03)00087-0

Le Moine, 2000, Cold liver ischemia-reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in mice., Hepatology, 31, 1266, 10.1053/jhep.2000.7881

Simeonova, 2001, The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride., Toxicol Appl Pharmacol, 177, 112, 10.1006/taap.2001.9304

Yoshiji, 2000, Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model., Hepatology, 32, 1248, 10.1053/jhep.2000.20521

Yoshiji, 2001, Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats., Hepatology, 34, 745, 10.1053/jhep.2001.28231

Ferrari, 1998, Muscle regeneration by bone marrow-derived myogenic progenitors., Science, 279, 1528, 10.1126/science.279.5356.1528

Mezey, 2000, Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow., Science, 290, 1779, 10.1126/science.290.5497.1779

Orlic, 2001, Transplanted adult bone marrow cells repair myocardial infarcts in mice., Ann N Y Acad Sci, 938, 221, 10.1111/j.1749-6632.2001.tb03592.x

Krause, 2001, Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell., Cell, 105, 369, 10.1016/S0092-8674(01)00328-2

Wagers, 2002, Little evidence for developmental plasticity of adult hematopoietic stem cells., Science, 297, 2256, 10.1126/science.1074807

Wang, 2003, Cell fusion is the principal source of bone-marrow-derived hepatocytes., Nature, 422, 897, 10.1038/nature01531

Vassilopoulos, 2003, Transplanted bone marrow regenerates liver by cell fusion., Nature, 422, 901, 10.1038/nature01539

Orlic, 2001, Bone marrow cells regenerate infarcted myocardium., Nature, 410, 701, 10.1038/35070587

Rafii, 2003, Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration., Nat Med, 9, 702, 10.1038/nm0603-702

Park, 2002, The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue., Nat Biotechnol, 20, 1111, 10.1038/nbt751

Ourednik, 2002, Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons., Nat Biotechnol, 20, 1103, 10.1038/nbt750

Hess, 2003, Bone marrow-derived stem cells initiate pancreatic regeneration., Nat Biotechnol, 21, 763, 10.1038/nbt841

Markova, 2000, Serum leptin levels in patients with sideropenic and pernicious anemia: the influence of anemia treatment., Physiol Res, 49, 679

Ortiz, 2003, Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects., Proc Natl Acad Sci U S A, 100, 8407, 10.1073/pnas.1432929100

Thompson, 1998, Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis., Hepatology, 28, 1597, 10.1002/hep.510280620

Tilg, 2003, Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis., J Hepatol, 38, 419, 10.1016/S0168-8278(02)00442-7