Systemic DNA damage responses: organismal adaptations to genome instability

Loeb, 2008, Advances in chemical carcinogenesis: a historical review and prospective, Cancer Res., 68, 6863, 10.1158/0008-5472.CAN-08-2852 De Bont, 2004, Endogenous DNA damage in humans: a review of quantitative data, Mutagenesis, 19, 169, 10.1093/mutage/geh025 Weinert, 1989, Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae, J. Cell Sci. Suppl., 12, 145, 10.1242/jcs.1989.Supplement_12.12 Rowley, 1992, The wee1 protein kinase is required for radiation-induced mitotic delay, Nature, 356, 353, 10.1038/356353a0 Harper, 2007, The DNA damage response: ten years after, Mol. Cell, 28, 739, 10.1016/j.molcel.2007.11.015 Jackson, 2009, The DNA-damage response in human biology and disease, Nature, 461, 1071, 10.1038/nature08467 Lane, 1992, Cancer. p53, guardian of the genome, Nature, 358, 15, 10.1038/358015a0 Lane, 2010, p53 research: the past thirty years and the next thirty years, Cold Spring Harb. Perspect. Biol., 2, a000893, 10.1101/cshperspect.a000893 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 Hahn, 1999, Creation of human tumour cells with defined genetic elements, Nature, 400, 464, 10.1038/22780 Reinhardt, 2012, The p53 network: cellular and systemic DNA damage responses in aging and cancer, Trends Genet., 28, 128, 10.1016/j.tig.2011.12.002 Deans, 2011, DNA interstrand crosslink repair and cancer, Nat. Rev. Cancer, 11, 467, 10.1038/nrc3088 Andreassen, 2009, Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy, Curr. Cancer Drug Targets, 9, 101, 10.2174/156800909787314011 Shiloh, 2003, ATM and related protein kinases: safeguarding genome integrity, Nat. Rev. Cancer, 3, 155, 10.1038/nrc1011 Schumacher, 2008, Age to survive: DNA damage and aging, Trends Genet., 24, 77, 10.1016/j.tig.2007.11.004 Vermeulen, 2001, A temperature-sensitive disorder in basal transcription and DNA repair in humans, Nat. Genet., 27, 299, 10.1038/85864 Schaeffer, 1993, DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor, Science, 260, 58, 10.1126/science.8465201 Andressoo, 2006, An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria, Cancer Cell, 10, 121, 10.1016/j.ccr.2006.05.027 Laugel, 2010, Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome, Hum. Mutat., 31, 113, 10.1002/humu.21154 Mostoslavsky, 2006, Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 124, 315, 10.1016/j.cell.2005.11.044 Ju, 2007, Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment, Nat. Med., 13, 742, 10.1038/nm1578 Niedernhofer, 2006, A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis, Nature, 444, 1038, 10.1038/nature05456 van der Pluijm, 2006, Impaired genome maintenance suppresses the growth hormone–insulin-like growth factor 1 axis in mice with Cockayne syndrome, PLoS Biol., 5, e2, 10.1371/journal.pbio.0050002 Garinis, 2009, Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity, Nat. Cell Biol., 11, 604, 10.1038/ncb1866 Mariño, 2010, Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function, Proc. Natl. Acad. Sci. U.S.A., 107, 16268, 10.1073/pnas.1002696107 Schwer, 2010, Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity, Proc. Natl. Acad. Sci. U.S.A., 107, 21790, 10.1073/pnas.1016306107 Schumacher, 2008, Delayed and accelerated aging share common longevity assurance mechanisms, PLoS Genet., 4, e1000161, 10.1371/journal.pgen.1000161 Karakasilioti, 2013, DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria, Cell Metab., 18, 403, 10.1016/j.cmet.2013.08.011 Osorio, 2012, Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response, Genes Dev., 26, 2311, 10.1101/gad.197954.112 Tilstra, 2012, NF-κB inhibition delays DNA damage-induced senescence and aging in mice, J. Clin. Invest., 122, 2601, 10.1172/JCI45785 Lee, 2013, Molecular mechanisms of UV-induced apoptosis and its effects on skin residential cells: the implication in UV-based phototherapy, Int. J. Mol. Sci., 14, 6414, 10.3390/ijms14036414 Schwarz, 2005, Mechanisms of UV-induced immunosuppression, Keio J. Med., 54, 165, 10.2302/kjm.54.165 Gasser, 2005, The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor, Nature, 436, 1186, 10.1038/nature03884 Muruve, 2008, The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response, Nature, 452, 103, 10.1038/nature06664 Rodier, 2009, Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion, Nat. Cell Biol., 11, 973, 10.1038/ncb1909 Liu, 2007, Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion, Cancer Res., 67, 3117, 10.1158/0008-5472.CAN-06-3452 Kang, 2011, Senescence surveillance of pre-malignant hepatocytes limits liver cancer development, Nature, 479, 547, 10.1038/nature10599 Xue, 2007, Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas, Nature, 445, 656, 10.1038/nature05529 Lujambio, 2013, Non-cell-autonomous tumor suppression by p53, Cell, 153, 449, 10.1016/j.cell.2013.03.020 Baker, 2004, BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice, Nat. Genet., 36, 744, 10.1038/ng1382 Baker, 2011, Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders, Nature, 470, 232, 10.1038/nature10600 Gregorio, 2010, Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons, J. Exp. Med., 207, 2921, 10.1084/jem.20101102 Jun, 2010, The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing, Nat. Cell Biol., 12, 676, 10.1038/ncb2070 Li, 2010, Apoptotic cells activate the ‘phoenix rising’ pathway to promote wound healing and tissue regeneration, Sci. Signal., 3, ra13, 10.1126/scisignal.2000634 Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016/j.cell.2004.07.002 Fukata, 2005, Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis, Am. J. Physiol. Gastrointest. Liver Physiol., 288, G1055, 10.1152/ajpgi.00328.2004 Ii, 2012, TLR9 is important for protection against intestinal damage and for intestinal repair, Sci. Rep., 2, 574, 10.1038/srep00574 Karpac, 2011, Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage, Dev. Cell, 20, 841, 10.1016/j.devcel.2011.05.011 Jiang, 2009, Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut, Cell, 137, 1343, 10.1016/j.cell.2009.05.014 Iizuka, 2011, Wound healing of intestinal epithelial cells, World J. Gastroenterol., 17, 2161, 10.3748/wjg.v17.i17.2161 Ermolaeva, 2013, DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance, Nature, 501, 416, 10.1038/nature12452 Johnson, 1988, Radiation effects on life span in Caenorhabditis elegans, J. Gerontol., 43, B137, 10.1093/geronj/43.5.B137 Schumacher, 2001, The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis, Curr. Biol., 11, 1722, 10.1016/S0960-9822(01)00534-6 Derry, 2001, Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance, Science, 294, 591, 10.1126/science.1065486 Gartner, 2000, A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans, Mol. Cell, 5, 435, 10.1016/S1097-2765(00)80438-4 Kim, 2002, A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity, Science, 297, 623, 10.1126/science.1073759 Vilchez, 2012, RPN-6 determines C. elegans longevity under proteotoxic stress conditions, Nature, 489, 263, 10.1038/nature11315 Richardson, 2010, An essential role for XBP-1 in host protection against immune activation in C. elegans, Nature, 463, 1092, 10.1038/nature08762 Ermolaeva, 2013, The innate immune system as mediator of systemic DNA damage responses, Commun. Integr. Biol., 6, e26926, 10.4161/cib.26926 Kirkwood, 2005, Understanding the odd science of aging, Cell, 120, 437, 10.1016/j.cell.2005.01.027 Felix, 2011, Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses, PLoS Biol., 9, e1000586, 10.1371/journal.pbio.1000586 Irazoqui, 2010, Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates, Nat. Rev. Immunol., 10, 47, 10.1038/nri2689 Troemel, 2006, p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans, PLoS Genet., 2, e183, 10.1371/journal.pgen.0020183 Schulenburg, 2008, Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans, Immunobiology, 213, 237, 10.1016/j.imbio.2007.12.004 Bork, 1993, The CUB domain. A widespread module in developmentally regulated proteins, J. Mol. Biol., 231, 539, 10.1006/jmbi.1993.1305 Thomas, 2006, Concerted evolution of two novel protein families in Caenorhabditis species, Genetics, 172, 2269, 10.1534/genetics.105.052746 Pujol, 2008, Distinct innate immune responses to infection and wounding in the C. elegans epidermis, Curr. Biol., 18, 481, 10.1016/j.cub.2008.02.079 Hodgkin, 2000, A novel bacterial pathogen, Microbacterium nematophilum, induces morphological change in the nematode C. elegans, Curr. Biol., 10, 1615, 10.1016/S0960-9822(00)00867-8 Nicholas, 2004, The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans, Curr. Biol., 14, 1256, 10.1016/j.cub.2004.07.022